The University of Southampton
University of Southampton Institutional Repository

Practical synthesis of chiral vinylphosphine oxides by direct nucleophilic substitution. Stereodivergent synthesis of aminophosphine ligands

Record type: Article

A practical synthesis of optically pure alkylphenylvinylphosphine oxides is described, utilizing a nucleophilic displacement at phosphorus to install the vinyl moiety. The products were used to prepare classes of P-stereogenic aminophosphine (PN) and aminohydroxyphosphine (PNO) ligands. Stereocontrol can be exerted at various stages of the synthesis, to provide specific combinations of chirality in the final product. The effect of the stereogenic phosphorus and match-mismatch of chiralities of PNO ligands were examined in the asymmetric ruthenium-catalyzed hydrogen transfer reduction of three aryl ketones.

Full text not available from this repository.

Citation

Oliana, M., King, F., Horton, P.N., Hursthouse, M.B. and Hii, K.K. (2006) Practical synthesis of chiral vinylphosphine oxides by direct nucleophilic substitution. Stereodivergent synthesis of aminophosphine ligands Journal of Organic Chemistry, 71, (6), pp. 2472-2479. (doi:10.1021/jo052575q).

More information

Published date: 2006

Identifiers

Local EPrints ID: 44514
URI: http://eprints.soton.ac.uk/id/eprint/44514
ISSN: 0022-3263
PURE UUID: ad04f863-934d-46a3-b155-ea63e366118f
ORCID for P.N. Horton: ORCID iD orcid.org/0000-0001-8886-2016

Catalogue record

Date deposited: 05 Mar 2007
Last modified: 17 Jul 2017 15:14

Export record

Altmetrics

Contributors

Author: M. Oliana
Author: F. King
Author: P.N. Horton ORCID iD
Author: M.B. Hursthouse
Author: K.K. Hii

University divisions


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×