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Physical activity monitoring to assess disability progression in multiple sclerosis

Physical activity monitoring to assess disability progression in multiple sclerosis
Physical activity monitoring to assess disability progression in multiple sclerosis
Background: Clinical outcome measurement in multiple sclerosis (MS) usually requires a physical visit. Remote activity monitoring (RAM) using wearable technology provides a rational alternative, especially desirable when distance is involved or in a pandemic setting.

Objective: To validate RAM in progressive MS using (1) traditional psychometric methods (2) brain atrophy.

Methods: 56 people with progressive MS participated in a longitudinal study over 2.5 years. An armworn RAM device measured activity over six days, every six months, and incorporated triaxial accelerometry and transcutaneous physiological variable measurement. Five RAM variables were assessed: physical activity duration, step count, active energy expenditure, metabolic equivalents and a composite RAM score incorporating all four variables. Other assessments every six months included EDSS, MSFC, MSIS-29, Chalder Fatigue Scale and Beck’s Depression Inventory. Annualized brain atrophy was measured using SIENA.

Results: RAM was tolerated well by people with MS; the device was worn 99.4% of the time. RAM had good convergent and divergent validity and was responsive, especially with respect to step count. Measurement of physical activity over one day was as responsive as six days. The composite RAM score positively correlated with brain volume loss.

Conclusion: Remote activity monitoring is a valid and acceptable outcome measure in MS.
2055-2173
2055217320975185
Stuart, Charlotte
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Varatharaj, Aravinthan
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Domjan, Janine
d9283626-a32f-4bae-83ba-699395906305
Philip, Sheaba
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Galea, Ian
66209a2f-f7e6-4d63-afe4-e9299f156f0b
SIMS study group
Stuart, Charlotte
0db8a733-f236-4baa-955c-d6e147dc9387
Varatharaj, Aravinthan
33d833af-9459-4b21-8489-ce9c0b6a09e0
Domjan, Janine
d9283626-a32f-4bae-83ba-699395906305
Philip, Sheaba
050a4b44-0af8-438b-ad06-3a48c172e23d
Galea, Ian
66209a2f-f7e6-4d63-afe4-e9299f156f0b

Stuart, Charlotte, Varatharaj, Aravinthan, Domjan, Janine, Philip, Sheaba and Galea, Ian , SIMS study group (2020) Physical activity monitoring to assess disability progression in multiple sclerosis. Multiple Sclerosis Journal – Experimental, Translational and Clinical, 6 (4), 2055217320975185. (doi:10.1177/2055217320975185).

Record type: Article

Abstract

Background: Clinical outcome measurement in multiple sclerosis (MS) usually requires a physical visit. Remote activity monitoring (RAM) using wearable technology provides a rational alternative, especially desirable when distance is involved or in a pandemic setting.

Objective: To validate RAM in progressive MS using (1) traditional psychometric methods (2) brain atrophy.

Methods: 56 people with progressive MS participated in a longitudinal study over 2.5 years. An armworn RAM device measured activity over six days, every six months, and incorporated triaxial accelerometry and transcutaneous physiological variable measurement. Five RAM variables were assessed: physical activity duration, step count, active energy expenditure, metabolic equivalents and a composite RAM score incorporating all four variables. Other assessments every six months included EDSS, MSFC, MSIS-29, Chalder Fatigue Scale and Beck’s Depression Inventory. Annualized brain atrophy was measured using SIENA.

Results: RAM was tolerated well by people with MS; the device was worn 99.4% of the time. RAM had good convergent and divergent validity and was responsive, especially with respect to step count. Measurement of physical activity over one day was as responsive as six days. The composite RAM score positively correlated with brain volume loss.

Conclusion: Remote activity monitoring is a valid and acceptable outcome measure in MS.

Text
Stuart et al 2020 - Accepted Manuscript
Available under License Creative Commons Attribution.
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More information

Accepted/In Press date: 31 October 2020
e-pub ahead of print date: 7 December 2020

Identifiers

Local EPrints ID: 445228
URI: http://eprints.soton.ac.uk/id/eprint/445228
ISSN: 2055-2173
PURE UUID: 935a141c-cb78-4c7b-8181-115a763f9f99
ORCID for Charlotte Stuart: ORCID iD orcid.org/0000-0002-5779-5487
ORCID for Aravinthan Varatharaj: ORCID iD orcid.org/0000-0003-1629-5774
ORCID for Ian Galea: ORCID iD orcid.org/0000-0002-1268-5102

Catalogue record

Date deposited: 25 Nov 2020 17:33
Last modified: 26 Nov 2021 06:58

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Contributors

Author: Janine Domjan
Author: Sheaba Philip
Author: Ian Galea ORCID iD
Corporate Author: SIMS study group

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