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Rheumatoid arthritis and bone health

Rheumatoid arthritis and bone health
Rheumatoid arthritis and bone health
Rheumatoid Arthritis (RA) is an inflammatory arthropathy affecting 1% of the population, with a female predominance. Systemic inflammation is a key component of RA disease; corticosteroids are often required to rapidly control disease activity. Both inflammation and corticosteroids, however, have an adverse effect on bone mineral density, potentially resulting in osteoporosis and an increased risk of fractures. In this article we describe the link between RA and impaired bone health, together with appropriate strategies to maintain bone density and reduce fracture risk. Key approaches include achieving adequate control of inflammation, minimising corticosteroid use, monitoring bone mineral density and intervening with antiosteoporosis medications when indicated
1470-2118
Ashai, Shanze
57374c08-ecbb-4304-a4bf-74aac8fb65d8
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Ashai, Shanze
57374c08-ecbb-4304-a4bf-74aac8fb65d8
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145

Ashai, Shanze and Harvey, Nicholas (2020) Rheumatoid arthritis and bone health. Clinical Medicine. (In Press)

Record type: Article

Abstract

Rheumatoid Arthritis (RA) is an inflammatory arthropathy affecting 1% of the population, with a female predominance. Systemic inflammation is a key component of RA disease; corticosteroids are often required to rapidly control disease activity. Both inflammation and corticosteroids, however, have an adverse effect on bone mineral density, potentially resulting in osteoporosis and an increased risk of fractures. In this article we describe the link between RA and impaired bone health, together with appropriate strategies to maintain bone density and reduce fracture risk. Key approaches include achieving adequate control of inflammation, minimising corticosteroid use, monitoring bone mineral density and intervening with antiosteoporosis medications when indicated

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Shanze-RA-Bone-Submission 2020_10_05 - Accepted Manuscript
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Accepted/In Press date: 5 October 2020

Identifiers

Local EPrints ID: 445355
URI: http://eprints.soton.ac.uk/id/eprint/445355
ISSN: 1470-2118
PURE UUID: 9d8b241d-3101-4f2d-b980-68b603c40768
ORCID for Nicholas Harvey: ORCID iD orcid.org/0000-0002-8194-2512

Catalogue record

Date deposited: 03 Dec 2020 17:34
Last modified: 05 Oct 2021 04:01

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Contributors

Author: Shanze Ashai
Author: Nicholas Harvey ORCID iD

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