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Moringa oleifera leaf powder for type 2 diabetes: a pilot clinical trial

Moringa oleifera leaf powder for type 2 diabetes: a pilot clinical trial
Moringa oleifera leaf powder for type 2 diabetes: a pilot clinical trial
Background:
Moringa oleifera Lam. (Moringaceae) leaves are commonly used for diabetes in Mali. This pilot clinical study aimed to evaluate its effect on post-prandial blood glucose in preparation for a larger trial.

Methods:
Diabetic patients and non-diabetic healthy volunteers (35 each) were asked to fast for 13 hours on three occasions. Blood glucose was measured before and after eating 100g of white bread (at 30, 60, 90, 120, 150 and 180 minutes). On their second and third study visits, they were given 1g and 2g respectively of M. oleifera leaf powder, 30 minutes after eating the bread. We calculated the mean paired reduction in blood glucose at each time interval and the incremental area under the curve.

Results:
Ingestion of Moringa powder had no effect on blood glucose in non-diabetic participants, but in diabetic patients, it lowered blood glucose at 90 minutes. There was a trend towards lower incremental area under the curve when diabetic patients took 2g of Moringa. No side-effects were reported by any participants.

Conclusions:
Moringa oleifera leaf powder reduced post-prandial glycaemia in diabetic patients. A larger study is needed to define the optimal dose and to assess whether this translates into longer-term benefits.
Moringa oleifera; Type 2 diabetes; clinical trial
0189-6016
29-36
Sissoko, Lassana
0c7528ff-1e05-4122-b3a4-d1f0b160e57a
Diarra, Nouhoum
740a04fc-0e48-466d-8e46-4769d3d3e832
Nientao, Ibrahim
9d438b35-f860-449c-8e69-119ff0fee2a0
Stuart, Beth
626862fc-892b-4f6d-9cbb-7a8d7172b209
Togola, Adiaratou
5ad4e84c-b2eb-47b0-a1fa-456922ed1d61
Diallo, Drissa
39a791e4-1b09-4733-b9c1-693fc53188eb
Willcox, Merlin
dad5b622-9ac2-417d-9b2e-aad41b64ffea
Sissoko, Lassana
0c7528ff-1e05-4122-b3a4-d1f0b160e57a
Diarra, Nouhoum
740a04fc-0e48-466d-8e46-4769d3d3e832
Nientao, Ibrahim
9d438b35-f860-449c-8e69-119ff0fee2a0
Stuart, Beth
626862fc-892b-4f6d-9cbb-7a8d7172b209
Togola, Adiaratou
5ad4e84c-b2eb-47b0-a1fa-456922ed1d61
Diallo, Drissa
39a791e4-1b09-4733-b9c1-693fc53188eb
Willcox, Merlin
dad5b622-9ac2-417d-9b2e-aad41b64ffea

Sissoko, Lassana, Diarra, Nouhoum, Nientao, Ibrahim, Stuart, Beth, Togola, Adiaratou, Diallo, Drissa and Willcox, Merlin (2020) Moringa oleifera leaf powder for type 2 diabetes: a pilot clinical trial. African Journal of Traditional, Complementary and Alternative Medicines, 17 (2), 29-36. (doi:10.21010/ajtcam.v17i2.3).

Record type: Article

Abstract

Background:
Moringa oleifera Lam. (Moringaceae) leaves are commonly used for diabetes in Mali. This pilot clinical study aimed to evaluate its effect on post-prandial blood glucose in preparation for a larger trial.

Methods:
Diabetic patients and non-diabetic healthy volunteers (35 each) were asked to fast for 13 hours on three occasions. Blood glucose was measured before and after eating 100g of white bread (at 30, 60, 90, 120, 150 and 180 minutes). On their second and third study visits, they were given 1g and 2g respectively of M. oleifera leaf powder, 30 minutes after eating the bread. We calculated the mean paired reduction in blood glucose at each time interval and the incremental area under the curve.

Results:
Ingestion of Moringa powder had no effect on blood glucose in non-diabetic participants, but in diabetic patients, it lowered blood glucose at 90 minutes. There was a trend towards lower incremental area under the curve when diabetic patients took 2g of Moringa. No side-effects were reported by any participants.

Conclusions:
Moringa oleifera leaf powder reduced post-prandial glycaemia in diabetic patients. A larger study is needed to define the optimal dose and to assess whether this translates into longer-term benefits.

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More information

Accepted/In Press date: 17 September 2020
e-pub ahead of print date: 18 November 2020
Keywords: Moringa oleifera; Type 2 diabetes; clinical trial

Identifiers

Local EPrints ID: 445379
URI: http://eprints.soton.ac.uk/id/eprint/445379
ISSN: 0189-6016
PURE UUID: a8d7276b-b787-4c4b-87c0-32e01c56bcc7
ORCID for Beth Stuart: ORCID iD orcid.org/0000-0001-5432-7437
ORCID for Merlin Willcox: ORCID iD orcid.org/0000-0002-5227-3444

Catalogue record

Date deposited: 07 Dec 2020 17:30
Last modified: 13 Dec 2021 03:21

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Contributors

Author: Lassana Sissoko
Author: Nouhoum Diarra
Author: Ibrahim Nientao
Author: Beth Stuart ORCID iD
Author: Adiaratou Togola
Author: Drissa Diallo
Author: Merlin Willcox ORCID iD

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