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Synthesis of unsymmetrical tweezer receptor libraries and identification of receptors for Lys-D-Ala-D-Ala in aqueous solution

Synthesis of unsymmetrical tweezer receptor libraries and identification of receptors for Lys-D-Ala-D-Ala in aqueous solution
Synthesis of unsymmetrical tweezer receptor libraries and identification of receptors for Lys-D-Ala-D-Ala in aqueous solution
Libraries of "unsymmetrical" tweezer receptors, featuring a guanidinium head group as a carboxylate binding site and two independently synthesized peptidic arms, have been prepared and screened to identify receptors for the N-Ac-Lys-D-Ala-D-Ala tri-peptide sequence. The binding properties of one such receptor structure, with dye-labeled N-Ac-LyS-D-Ala-D-Ala, were investigated. These studies demonstrated that when attached to the solid-phase, the receptor binds dye-labeled N-Ac-Lys-D-Ala-D-Ala, in buffered aqueous media, with mm binding affinity.
library, peptides, receptors, solid-phase synthesis sequence selective binding, solid-phase synthesis, combinatorial library, artificial receptors, peptide receptors, protecting group, water, recognition, vancomycin, resistance
0947-6539
713-720
Shepherd, Jon
fb416f96-4326-4cff-bfa7-02fc55c4d90e
Gale, Tom
ea5bed5e-fa25-4f82-8aa2-4752302dbfb7
Jensen, Kim B.
2e68bc78-ac0f-4961-bb2b-ca0ecb769925
Kilburn, Jeremy D.
e64ded70-825a-40ec-816b-c4605e007e7a
Shepherd, Jon
fb416f96-4326-4cff-bfa7-02fc55c4d90e
Gale, Tom
ea5bed5e-fa25-4f82-8aa2-4752302dbfb7
Jensen, Kim B.
2e68bc78-ac0f-4961-bb2b-ca0ecb769925
Kilburn, Jeremy D.
e64ded70-825a-40ec-816b-c4605e007e7a

Shepherd, Jon, Gale, Tom, Jensen, Kim B. and Kilburn, Jeremy D. (2006) Synthesis of unsymmetrical tweezer receptor libraries and identification of receptors for Lys-D-Ala-D-Ala in aqueous solution. Chemistry - A European Journal, 12 (3), 713-720. (doi:10.1002/chem.200500876).

Record type: Article

Abstract

Libraries of "unsymmetrical" tweezer receptors, featuring a guanidinium head group as a carboxylate binding site and two independently synthesized peptidic arms, have been prepared and screened to identify receptors for the N-Ac-Lys-D-Ala-D-Ala tri-peptide sequence. The binding properties of one such receptor structure, with dye-labeled N-Ac-LyS-D-Ala-D-Ala, were investigated. These studies demonstrated that when attached to the solid-phase, the receptor binds dye-labeled N-Ac-Lys-D-Ala-D-Ala, in buffered aqueous media, with mm binding affinity.

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Published date: 2006
Keywords: library, peptides, receptors, solid-phase synthesis sequence selective binding, solid-phase synthesis, combinatorial library, artificial receptors, peptide receptors, protecting group, water, recognition, vancomycin, resistance

Identifiers

Local EPrints ID: 44544
URI: http://eprints.soton.ac.uk/id/eprint/44544
ISSN: 0947-6539
PURE UUID: e734ddc5-9d7b-4981-a9fa-05d9b51d2811

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Date deposited: 06 Mar 2007
Last modified: 13 Mar 2019 21:07

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