Synthesis of unsymmetrical tweezer receptor libraries and identification of receptors for Lys-D-Ala-D-Ala in aqueous solution

Shepherd, Jon, Gale, Tom, Jensen, Kim B. and Kilburn, Jeremy D. (2006) Synthesis of unsymmetrical tweezer receptor libraries and identification of receptors for Lys-D-Ala-D-Ala in aqueous solution. Chemistry - A European Journal, 12 (3), 713-720. (doi:10.1002/chem.200500876).

Record type: Article

Abstract

Libraries of "unsymmetrical" tweezer receptors, featuring a guanidinium head group as a carboxylate binding site and two independently synthesized peptidic arms, have been prepared and screened to identify receptors for the N-Ac-Lys-D-Ala-D-Ala tri-peptide sequence. The binding properties of one such receptor structure, with dye-labeled N-Ac-LyS-D-Ala-D-Ala, were investigated. These studies demonstrated that when attached to the solid-phase, the receptor binds dye-labeled N-Ac-Lys-D-Ala-D-Ala, in buffered aqueous media, with mm binding affinity.

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Published date: 2006

Related URLs:

http://www.ncbi.nlm.nih.gov/en...med_DocSum

Keywords: library, peptides, receptors, solid-phase synthesis sequence selective binding, solid-phase synthesis, combinatorial library, artificial receptors, peptide receptors, protecting group, water, recognition, vancomycin, resistance

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