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Sensitive detection of SARS-CoV-2-specific antibodies in dried blood spot samples

Sensitive detection of SARS-CoV-2-specific antibodies in dried blood spot samples
Sensitive detection of SARS-CoV-2-specific antibodies in dried blood spot samples

Dried blood spot (DBS) samples can be used for the detection of severe acute respiratory syndrome coronavirus 2 spike antibodies. DBS sampling is comparable to matched serum samples with a relative 98.1% sensitivity and 100% specificity. Thus, DBS sampling offers an alternative for population-wide serologic testing in the coronavirus pandemic.

COVID-19, DBS, SARS-CoV-2, antibody, coronavirus disease, dried blood spot, respiratory infections, severe acute respiratory syndrome coronavirus 2, viruses, zoonoses
1080-6059
2970-2973
Morley, Gabriella L
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Jossi, Sian
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Perez-Toledo, Marisol
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Faustini, Sian E
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Marcial-Juarez, Edith
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Shields, Adrian M
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Goodall, Margaret
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Allen, Joel D
c873d886-2a66-475b-ae04-57a10b37e716
Watanabe, Yasunori
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Newby, Maddy L
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Crispin, Max
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Drayson, Mark T
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Cunningham, Adam F
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Richter, Alex G
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O'Shea, Matthew K
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Morley, Gabriella L
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Jossi, Sian
b6e73f03-47eb-47f1-9c62-d9cfb71c280b
Perez-Toledo, Marisol
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Faustini, Sian E
fc25e886-bb2c-4c9c-a421-df8e00e6b1ba
Marcial-Juarez, Edith
071ab53d-fb37-49fd-b467-4448692adab3
Shields, Adrian M
2c945fb6-b12f-487d-8b6b-bbdd321a13db
Goodall, Margaret
27208c10-af66-47b3-b23d-57b343e27868
Allen, Joel D
c873d886-2a66-475b-ae04-57a10b37e716
Watanabe, Yasunori
8c0ee4af-a293-4de5-9036-3ce2051b380c
Newby, Maddy L
417cba47-6a6f-42b9-8b9c-640f0518c621
Crispin, Max
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Drayson, Mark T
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Cunningham, Adam F
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Richter, Alex G
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O'Shea, Matthew K
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Morley, Gabriella L, Jossi, Sian, Perez-Toledo, Marisol, Faustini, Sian E, Marcial-Juarez, Edith, Shields, Adrian M, Goodall, Margaret, Allen, Joel D, Watanabe, Yasunori, Newby, Maddy L, Crispin, Max, Drayson, Mark T, Cunningham, Adam F, Richter, Alex G and O'Shea, Matthew K (2020) Sensitive detection of SARS-CoV-2-specific antibodies in dried blood spot samples. Emerging Infectious Diseases, 26 (12), 2970-2973. (doi:10.3201/eid2612.203309).

Record type: Article

Abstract

Dried blood spot (DBS) samples can be used for the detection of severe acute respiratory syndrome coronavirus 2 spike antibodies. DBS sampling is comparable to matched serum samples with a relative 98.1% sensitivity and 100% specificity. Thus, DBS sampling offers an alternative for population-wide serologic testing in the coronavirus pandemic.

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More information

e-pub ahead of print date: 24 September 2020
Published date: 1 December 2020
Keywords: COVID-19, DBS, SARS-CoV-2, antibody, coronavirus disease, dried blood spot, respiratory infections, severe acute respiratory syndrome coronavirus 2, viruses, zoonoses

Identifiers

Local EPrints ID: 445471
URI: http://eprints.soton.ac.uk/id/eprint/445471
ISSN: 1080-6059
PURE UUID: dc90d5d1-700d-458b-a628-135d73de2ce9
ORCID for Max Crispin: ORCID iD orcid.org/0000-0002-1072-2694

Catalogue record

Date deposited: 10 Dec 2020 17:31
Last modified: 18 Feb 2021 17:31

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