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Pubertal onset with adulthood lung function mediated by height growth in adolescence

Pubertal onset with adulthood lung function mediated by height growth in adolescence
Pubertal onset with adulthood lung function mediated by height growth in adolescence

Background: Age of pubertal onset is associated with height and lung function in adulthood. It is unknown whether height growth in adolescence mediates the association of age at puberty with early adult lung function.

Methods: Data from the Isle of Wight (IOW) birth cohort (n=1261) were examined in the study. Ages of pubertal events, height at ages 10 and 18 years and lung function parameters (forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV 1)) at 26 years were included in a path analysis to assess the mediation effects of height growth. Findings were tested in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort.

Results: In females in the IOW cohort, age at menarche and body hair growth showed a positive indirect association with FVC (menarche: indirect effect coefficient (IEC)=0.13, 95% CI 0.05-0.20, p=1.28×10 -3; body hair growth: IEC=0.08, 95% CI 0.01-0.15, p=0.017) and FEV 1 (menarche: IEC=0.09, 95% CI 0.01-0.17, p=0.028; body hair growth: IEC=0.07, 95% CI 0.01-0.14, p=0.043) at 26 years through height growth and lung function at 18 years. In males, age at body hair growth (IEC=0.08; 95% CI 0.01-0.15, p=0.047), growth spurt (IEC=0.09; 95% CI 0.01-0.17, p=0.034) and facial hair growth (IEC=0.09; 95% CI 0.02-0.16, p=0.014) had positive indirect effects on FVC at 26 years, but voice deepening did not show statistically significant indirect effects (p>0.05). For pubertal events available in the ALSPAC cohort, results consistent with the IOW cohort were found for both females and males.

Conclusion: Effects of age of puberty on FVC in early adulthood are likely mediated by height growth during adolescence.

2312-0541
Li, Liang
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Zhang, Hongmei
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Holloway, John W.
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Henderson, A. John
03d06941-3f2c-4a2e-998b-8d18124049d1
Ewart, Susan
28667421-3cf7-43d7-b1c3-ca27564938f7
Relton, Caroline L.
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Arshad, S. Hasan
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Arshad, Syed
917e246d-2e60-472f-8d30-94b01ef28958
Karmaus, Wilfried
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Li, Liang
a931b098-18d9-4b69-8d07-cce0d8051b7a
Zhang, Hongmei
9f774048-54d6-4321-a252-3887b2c76db0
Holloway, John W.
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Henderson, A. John
03d06941-3f2c-4a2e-998b-8d18124049d1
Ewart, Susan
28667421-3cf7-43d7-b1c3-ca27564938f7
Relton, Caroline L.
7a9fe7f7-d14b-4bb7-be71-a3afa6ff8538
Arshad, S. Hasan
795d8599-b77d-44e5-bb9c-67db78822057
Arshad, Syed
917e246d-2e60-472f-8d30-94b01ef28958
Karmaus, Wilfried
281d0e53-6b5d-4d38-9732-3981b07cd853

Li, Liang, Zhang, Hongmei, Holloway, John W., Henderson, A. John, Ewart, Susan, Relton, Caroline L., Arshad, S. Hasan, Arshad, Syed and Karmaus, Wilfried (2020) Pubertal onset with adulthood lung function mediated by height growth in adolescence. ERJ Open Research, 6 (4), [00535-2020]. (doi:10.1183/23120541.00535-2020).

Record type: Article

Abstract

Background: Age of pubertal onset is associated with height and lung function in adulthood. It is unknown whether height growth in adolescence mediates the association of age at puberty with early adult lung function.

Methods: Data from the Isle of Wight (IOW) birth cohort (n=1261) were examined in the study. Ages of pubertal events, height at ages 10 and 18 years and lung function parameters (forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV 1)) at 26 years were included in a path analysis to assess the mediation effects of height growth. Findings were tested in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort.

Results: In females in the IOW cohort, age at menarche and body hair growth showed a positive indirect association with FVC (menarche: indirect effect coefficient (IEC)=0.13, 95% CI 0.05-0.20, p=1.28×10 -3; body hair growth: IEC=0.08, 95% CI 0.01-0.15, p=0.017) and FEV 1 (menarche: IEC=0.09, 95% CI 0.01-0.17, p=0.028; body hair growth: IEC=0.07, 95% CI 0.01-0.14, p=0.043) at 26 years through height growth and lung function at 18 years. In males, age at body hair growth (IEC=0.08; 95% CI 0.01-0.15, p=0.047), growth spurt (IEC=0.09; 95% CI 0.01-0.17, p=0.034) and facial hair growth (IEC=0.09; 95% CI 0.02-0.16, p=0.014) had positive indirect effects on FVC at 26 years, but voice deepening did not show statistically significant indirect effects (p>0.05). For pubertal events available in the ALSPAC cohort, results consistent with the IOW cohort were found for both females and males.

Conclusion: Effects of age of puberty on FVC in early adulthood are likely mediated by height growth during adolescence.

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More information

Accepted/In Press date: 27 August 2020
e-pub ahead of print date: 10 November 2020
Additional Information: Copyright ©ERS 2020.

Identifiers

Local EPrints ID: 445516
URI: http://eprints.soton.ac.uk/id/eprint/445516
ISSN: 2312-0541
PURE UUID: a9357d84-aead-4f1f-b37d-8df8063a8fc0
ORCID for John W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464

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Date deposited: 14 Dec 2020 17:31
Last modified: 22 Nov 2021 02:41

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Contributors

Author: Liang Li
Author: Hongmei Zhang
Author: A. John Henderson
Author: Susan Ewart
Author: Caroline L. Relton
Author: S. Hasan Arshad
Author: Syed Arshad
Author: Wilfried Karmaus

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