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SP-A and SP-D: dual functioning immune molecules with antiviral and 1 immunomodulatory properties

SP-A and SP-D: dual functioning immune molecules with antiviral and 1 immunomodulatory properties
SP-A and SP-D: dual functioning immune molecules with antiviral and 1 immunomodulatory properties
Surfactant proteins A (SP-A) and D (SP-D) are soluble innate immune molecules which maintain lung homeostasis through their dual roles as anti-infectious and immunomodulatory agents. SP-A and SP- D bind numerous viruses including influenza A virus, respiratory syncytial virus (RSV) and human immunodeficiency virus (HIV), enhancing their clearance from mucosal points of entry and modulating the inflammatory response. They also have diverse roles in mediating innate and adaptive cell functions and in clearing apoptotic cells, allergens and other noxious particles. We summarize here how the properties of these first line defense molecules modulate inflammatory responses, as well as host-mediated immunopathology in response to viral infections.
Since SP-A and SP-D are known to offer protection from viral and other infections, if their levels are decreased in some disease states as they are in severe asthma and chronic obstructive pulmonary disease (COPD), this may confer an increased risk of viral infection and exacerbations of disease. Recombinant molecules of SP-A and SP-D could be useful in both blocking respiratory viral infection whilst also modulating the immune system to prevent excessive inflammatory responses seen in, for example, RSV or coronavirus disease 2019 (COVID-19). SP-A and SP-D could have therapeutic potential in neutralizing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus and modulating the inflammation-mediated pathology associated with COVID-19. Further work nvestigating the potential therapeutic role of SP-A and SP-D in COVID-19 and other infectious and inflammatory diseases is indicated
1664-3224
Watson, Alastair
9eb79329-8d32-4ed4-b8b9-d720883e8042
Madsen, Jens
b5d8ae35-00ac-4d19-930e-d8ddec497359
Clark, Howard
70550b6d-3bd7-47c6-8c02-4f43f37d5213
Watson, Alastair
9eb79329-8d32-4ed4-b8b9-d720883e8042
Madsen, Jens
b5d8ae35-00ac-4d19-930e-d8ddec497359
Clark, Howard
70550b6d-3bd7-47c6-8c02-4f43f37d5213

Watson, Alastair, Madsen, Jens and Clark, Howard (2020) SP-A and SP-D: dual functioning immune molecules with antiviral and 1 immunomodulatory properties. Frontiers in Immunology. (In Press)

Record type: Article

Abstract

Surfactant proteins A (SP-A) and D (SP-D) are soluble innate immune molecules which maintain lung homeostasis through their dual roles as anti-infectious and immunomodulatory agents. SP-A and SP- D bind numerous viruses including influenza A virus, respiratory syncytial virus (RSV) and human immunodeficiency virus (HIV), enhancing their clearance from mucosal points of entry and modulating the inflammatory response. They also have diverse roles in mediating innate and adaptive cell functions and in clearing apoptotic cells, allergens and other noxious particles. We summarize here how the properties of these first line defense molecules modulate inflammatory responses, as well as host-mediated immunopathology in response to viral infections.
Since SP-A and SP-D are known to offer protection from viral and other infections, if their levels are decreased in some disease states as they are in severe asthma and chronic obstructive pulmonary disease (COPD), this may confer an increased risk of viral infection and exacerbations of disease. Recombinant molecules of SP-A and SP-D could be useful in both blocking respiratory viral infection whilst also modulating the immune system to prevent excessive inflammatory responses seen in, for example, RSV or coronavirus disease 2019 (COVID-19). SP-A and SP-D could have therapeutic potential in neutralizing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus and modulating the inflammation-mediated pathology associated with COVID-19. Further work nvestigating the potential therapeutic role of SP-A and SP-D in COVID-19 and other infectious and inflammatory diseases is indicated

Text
Watson et al SPA SPD Viral Inflammation Submitted Proof. - Accepted Manuscript
Available under License Creative Commons Attribution.
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More information

Accepted/In Press date: 14 December 2020

Identifiers

Local EPrints ID: 445560
URI: http://eprints.soton.ac.uk/id/eprint/445560
ISSN: 1664-3224
PURE UUID: 77308878-a030-4a58-84cb-c72e42fde9ba
ORCID for Jens Madsen: ORCID iD orcid.org/0000-0003-1664-7645

Catalogue record

Date deposited: 16 Dec 2020 17:31
Last modified: 13 Dec 2021 03:00

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Contributors

Author: Alastair Watson
Author: Jens Madsen ORCID iD
Author: Howard Clark

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