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Evidence for adenoma-carcinoma sequence in the duodenum of patients with familial adenomatous polyposis

Evidence for adenoma-carcinoma sequence in the duodenum of patients with familial adenomatous polyposis
Evidence for adenoma-carcinoma sequence in the duodenum of patients with familial adenomatous polyposis

Aims: to explore the association between duodenal adenoma and carcinoma in patients with familial adenomatous polyposis (FAP). 

Methods: a multicentre survey of 1262 patients with FAP yielded 47 cases of duodenal cancer. The association between adenoma and cancer was assessed in these cases. 

Results: adenomatous tissue was found within duodenal cancer in 29 of 44 (66%) patients with FAP and in mucosa adjacent to duodenal cancer in 31 of 42 (73%) such patients. Adenomas were found as a component of, or adjacent to, duodenal cancer in 38 of 45 (84%) patients. 

Conclusions: these observations support the existence of the adenomacarcinoma sequence in the duodenum of patients with FAP. Factors associated with malignant change included villous histology, moderate or severe dysplasia, and the presence of stage IV duodenal polyposis.

0021-9746
709-710
Spigelman, A. D.
74e6d4b3-097b-4024-b89d-c3b4c0bd642a
Talbot, I. C.
b240135a-0cab-4162-b8a6-922fbeec492f
Penna, C.
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Nugent, K. P.
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Phillips, R. K.S.
d23a75c7-986b-4a83-87e4-e22abae5ade2
Costello, C.
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DeCosse, J. J.
ff5d86e5-06c4-4a16-aa99-27e9aff99f65
Spigelman, A. D.
74e6d4b3-097b-4024-b89d-c3b4c0bd642a
Talbot, I. C.
b240135a-0cab-4162-b8a6-922fbeec492f
Penna, C.
1976d1a7-3d56-4c57-ac82-bec422003632
Nugent, K. P.
79fcb89d-6ff2-47b8-ac2c-2afb24954456
Phillips, R. K.S.
d23a75c7-986b-4a83-87e4-e22abae5ade2
Costello, C.
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DeCosse, J. J.
ff5d86e5-06c4-4a16-aa99-27e9aff99f65

Spigelman, A. D., Talbot, I. C., Penna, C., Nugent, K. P., Phillips, R. K.S., Costello, C. and DeCosse, J. J. (1994) Evidence for adenoma-carcinoma sequence in the duodenum of patients with familial adenomatous polyposis. Journal of Clinical Pathology, 47 (8), 709-710. (doi:10.1136/jcp.47.8.709).

Record type: Article

Abstract

Aims: to explore the association between duodenal adenoma and carcinoma in patients with familial adenomatous polyposis (FAP). 

Methods: a multicentre survey of 1262 patients with FAP yielded 47 cases of duodenal cancer. The association between adenoma and cancer was assessed in these cases. 

Results: adenomatous tissue was found within duodenal cancer in 29 of 44 (66%) patients with FAP and in mucosa adjacent to duodenal cancer in 31 of 42 (73%) such patients. Adenomas were found as a component of, or adjacent to, duodenal cancer in 38 of 45 (84%) patients. 

Conclusions: these observations support the existence of the adenomacarcinoma sequence in the duodenum of patients with FAP. Factors associated with malignant change included villous histology, moderate or severe dysplasia, and the presence of stage IV duodenal polyposis.

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Published date: 1 August 1994

Identifiers

Local EPrints ID: 445566
URI: http://eprints.soton.ac.uk/id/eprint/445566
ISSN: 0021-9746
PURE UUID: f62c54e5-0ad3-48c6-bfe4-21d3ebeda8ca

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Date deposited: 16 Dec 2020 17:31
Last modified: 10 Jul 2024 20:31

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Contributors

Author: A. D. Spigelman
Author: I. C. Talbot
Author: C. Penna
Author: K. P. Nugent
Author: R. K.S. Phillips
Author: C. Costello
Author: J. J. DeCosse

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