On the nucleophilic tele-substitution of dichloropyrazines by metallated dithianes
On the nucleophilic tele-substitution of dichloropyrazines by metallated dithianes
The reaction of dichloropyrazines with a dithiane anion gave isomers of the expected formylated chloropyrazines after deprotection with methyl iodide. A tele-substitution mechanism accounts for these observations and is supported by deuterium labelling studies.
pyrazines, dithianes, tele-substitution, metallation
directed metalation, diazines pyridines, benzodiazines, pyridazines, pyrimidines, carbolines, quinolines, azines
31-34
Torr, Jane E.
47909823-e298-47d1-90ff-8ebb949d57cd
Large, Jonathan M.
d9c1378f-6ee3-4e1b-abf7-0fffa6a5fbf2
Horton, Peter N.
154c8930-bfc3-495b-ad4a-8a278d5da3a5
Hursthouse, Michael B.
57a2ddf9-b1b3-4f38-bfe9-ef2f526388da
McDonald, Edward
99fa0e30-4f4f-4814-8450-75e087ba3018
2006
Torr, Jane E.
47909823-e298-47d1-90ff-8ebb949d57cd
Large, Jonathan M.
d9c1378f-6ee3-4e1b-abf7-0fffa6a5fbf2
Horton, Peter N.
154c8930-bfc3-495b-ad4a-8a278d5da3a5
Hursthouse, Michael B.
57a2ddf9-b1b3-4f38-bfe9-ef2f526388da
McDonald, Edward
99fa0e30-4f4f-4814-8450-75e087ba3018
Torr, Jane E., Large, Jonathan M., Horton, Peter N., Hursthouse, Michael B. and McDonald, Edward
(2006)
On the nucleophilic tele-substitution of dichloropyrazines by metallated dithianes.
Tetrahedron Letters, 47 (1), .
(doi:10.1016/j.tetlet.2005.10.146).
Abstract
The reaction of dichloropyrazines with a dithiane anion gave isomers of the expected formylated chloropyrazines after deprotection with methyl iodide. A tele-substitution mechanism accounts for these observations and is supported by deuterium labelling studies.
This record has no associated files available for download.
More information
Published date: 2006
Keywords:
pyrazines, dithianes, tele-substitution, metallation
directed metalation, diazines pyridines, benzodiazines, pyridazines, pyrimidines, carbolines, quinolines, azines
Identifiers
Local EPrints ID: 44557
URI: http://eprints.soton.ac.uk/id/eprint/44557
ISSN: 0040-4039
PURE UUID: 909e9567-7018-4fcd-b62f-52a0a9a6d3ef
Catalogue record
Date deposited: 28 Feb 2007
Last modified: 16 Mar 2024 03:12
Export record
Altmetrics
Contributors
Author:
Jane E. Torr
Author:
Jonathan M. Large
Author:
Peter N. Horton
Author:
Edward McDonald
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics