A single-letter change in an acronym: signals, reasons, promises, challenges, and steps ahead for moving from NAFLD to MAFLD
A single-letter change in an acronym: signals, reasons, promises, challenges, and steps ahead for moving from NAFLD to MAFLD
Introduction: We are currently at the dawn of a revolution in the field of fatty liver diseases. Recently, a consensus recommended ‘metabolic (dysfunction) associated fatty liver disease’ (MAFLD) as a more appropriate name to describe fatty liver disease associated with metabolic dysfunction, ultimately suggesting that the old acronym nonalcoholic fatty liver disease (NAFLD) should be abandoned.
Areas covered: In this viewpoint, we discuss the reasons and relevance of this semantic modification through five different conceptual domains, i.e., 1) signals, 2) reasons, 2) promises, 4) challenges and 5) steps ahead.
Expert opinion: The road ahead will not be traveled without major challenges. Further research to evaluate the positive and negative impacts of the nomenclature change is warranted. However, this modification should encourage increased disease awareness among policymakers and stimulate public and private investments leading to more effective therapy development.
Disease rebranding, metabolic (dysfunction) associated fatty liver disease, nomenclature, nonalcoholic fatty liver disease
345-352
Yilmaz, Yusuf
dc7a129f-9262-4c8a-80db-c53e95f58482
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
Musso, Giovanni
1b868e2a-6848-4878-99b9-32808f1bd3b8
9 December 2020
Yilmaz, Yusuf
dc7a129f-9262-4c8a-80db-c53e95f58482
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
Musso, Giovanni
1b868e2a-6848-4878-99b9-32808f1bd3b8
Yilmaz, Yusuf, Byrne, Christopher and Musso, Giovanni
(2020)
A single-letter change in an acronym: signals, reasons, promises, challenges, and steps ahead for moving from NAFLD to MAFLD.
Expert Review of Gastroenterology & Hepatology, 15 (4), .
(doi:10.1080/17474124.2021.1860019).
Abstract
Introduction: We are currently at the dawn of a revolution in the field of fatty liver diseases. Recently, a consensus recommended ‘metabolic (dysfunction) associated fatty liver disease’ (MAFLD) as a more appropriate name to describe fatty liver disease associated with metabolic dysfunction, ultimately suggesting that the old acronym nonalcoholic fatty liver disease (NAFLD) should be abandoned.
Areas covered: In this viewpoint, we discuss the reasons and relevance of this semantic modification through five different conceptual domains, i.e., 1) signals, 2) reasons, 2) promises, 4) challenges and 5) steps ahead.
Expert opinion: The road ahead will not be traveled without major challenges. Further research to evaluate the positive and negative impacts of the nomenclature change is warranted. However, this modification should encourage increased disease awareness among policymakers and stimulate public and private investments leading to more effective therapy development.
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More information
Accepted/In Press date: 2 December 2020
e-pub ahead of print date: 9 December 2020
Published date: 9 December 2020
Additional Information:
Funding Information:
This paper was not funded. The authors thank Kathleen E. Corey (Liver Center, Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA) and Hannes Hagstr?m (Unit of Hepatology, Department of Upper GI, Karolinska University Hospital, Stockholm, Sweden) for helpful discussions.
Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.
Keywords:
Disease rebranding, metabolic (dysfunction) associated fatty liver disease, nomenclature, nonalcoholic fatty liver disease
Identifiers
Local EPrints ID: 445576
URI: http://eprints.soton.ac.uk/id/eprint/445576
ISSN: 1747-4124
PURE UUID: 7ec68a12-ba90-4748-8e4f-0477cc62fc85
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Date deposited: 16 Dec 2020 17:32
Last modified: 17 Mar 2024 06:09
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Author:
Yusuf Yilmaz
Author:
Giovanni Musso
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