Sharp DNA denaturation due to solvent interaction
Sharp DNA denaturation due to solvent interaction
Within the framework of the Peyrard-Bishop model for DNA melting, sharp denaturation temperature profiles can currently be obtained only if anharmonic base-pair stacking interactions are considered. We show that, when solvent interactions are included, a sharp denaturation of the DNA double helix is obtained without the need for anharmonic nearest-neighbor interactions. Using the concept of pseudo-Schrodinger equations we discuss the analogy of these transition to quantum-mechanical tunneling, and in particular we show that the sharp transitions are similar to resonant tunneling.
statistical-mechanics, thermal-denaturation, model, dynamics, simulations, transition
806-811
Weber, G.
2efb4751-cfcf-4500-9712-662056970679
2006
Weber, G.
2efb4751-cfcf-4500-9712-662056970679
Abstract
Within the framework of the Peyrard-Bishop model for DNA melting, sharp denaturation temperature profiles can currently be obtained only if anharmonic base-pair stacking interactions are considered. We show that, when solvent interactions are included, a sharp denaturation of the DNA double helix is obtained without the need for anharmonic nearest-neighbor interactions. Using the concept of pseudo-Schrodinger equations we discuss the analogy of these transition to quantum-mechanical tunneling, and in particular we show that the sharp transitions are similar to resonant tunneling.
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Published date: 2006
Keywords:
statistical-mechanics, thermal-denaturation, model, dynamics, simulations, transition
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Local EPrints ID: 44563
URI: http://eprints.soton.ac.uk/id/eprint/44563
ISSN: 0295-5075
PURE UUID: d0a74f52-7cd2-47bb-8959-b5953f2a305f
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Date deposited: 05 Mar 2007
Last modified: 15 Mar 2024 09:05
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Author:
G. Weber
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