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Impairment in quality of life is directly related to the level of allergen exposure and allergic airway inflammation

Impairment in quality of life is directly related to the level of allergen exposure and allergic airway inflammation
Impairment in quality of life is directly related to the level of allergen exposure and allergic airway inflammation

Background: Allergic disease has been shown to impair health-related quality of life (HRQL). The relationship between HRQL and either allergen exposure or allergic inflammation has not been previously assessed. Objective: To assess the relationship between HRQL and both grass pollen exposure and airway inflammation using the Paediatric Allergic Disease Quality of Life Questionnaire (PADQLQ). This is a novel questionnaire previously developed to assess the multi-system aspects of allergic disease. Methods: Eighty-four subjects, aged 6-17 years, with seasonal allergic rhinoconjunctivitis, asthma and/or cutaneous manifestations were assessed before and during the grass pollen season. They were assessed with the PADQLQ, a visual analogue scale (VAS) to assess quality of life, symptom diary and exhaled nitric oxide (FE NO). Results: HRQL, as measured by the PADQLQ, significantly correlated with the average pollen count in the previous week (regression coefficient 0.038, 95% confidence interval (CI) 0.027-0.049, P<0.001). The PADQLQ score was also found to be significantly associated with airway inflammation as measured by FENO (regression coefficient 0.410, 95% CI 0.175-0.646, P=0.001). Additionally, PADQLQ showed a high degree of correlation with symptom scores and quality of life as measured by a VAS, good within-subject reliability and a small minimal important difference (0.20, 95% CI -0.09 to 0.49 on a seven-point scale). Conclusion: HRQL is related to both allergen load and allergic inflammation and the PADQLQ has excellent cross-sectional and longitudinal validity with respect to quality of life and symptoms.

Asthma, Children, Eczema, Multi-system allergic disease, Quality of life, Rhinoconjunctivitis, Teenagers
0954-7894
1295-1300
Roberts, G.
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Mylonopoulou, M.
b1105b40-1000-4e3c-8845-8cdd2f869a9e
Hurley, C.
d89e9c7e-5518-415d-bab6-4f4873564140
Lack, G.
27fa8c20-ab77-4037-96f6-1e9298d71f68
Roberts, G.
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Mylonopoulou, M.
b1105b40-1000-4e3c-8845-8cdd2f869a9e
Hurley, C.
d89e9c7e-5518-415d-bab6-4f4873564140
Lack, G.
27fa8c20-ab77-4037-96f6-1e9298d71f68

Roberts, G., Mylonopoulou, M., Hurley, C. and Lack, G. (2005) Impairment in quality of life is directly related to the level of allergen exposure and allergic airway inflammation. Clinical and Experimental Allergy, 35 (10), 1295-1300. (doi:10.1111/j.1365-2222.2005.02333.x).

Record type: Article

Abstract

Background: Allergic disease has been shown to impair health-related quality of life (HRQL). The relationship between HRQL and either allergen exposure or allergic inflammation has not been previously assessed. Objective: To assess the relationship between HRQL and both grass pollen exposure and airway inflammation using the Paediatric Allergic Disease Quality of Life Questionnaire (PADQLQ). This is a novel questionnaire previously developed to assess the multi-system aspects of allergic disease. Methods: Eighty-four subjects, aged 6-17 years, with seasonal allergic rhinoconjunctivitis, asthma and/or cutaneous manifestations were assessed before and during the grass pollen season. They were assessed with the PADQLQ, a visual analogue scale (VAS) to assess quality of life, symptom diary and exhaled nitric oxide (FE NO). Results: HRQL, as measured by the PADQLQ, significantly correlated with the average pollen count in the previous week (regression coefficient 0.038, 95% confidence interval (CI) 0.027-0.049, P<0.001). The PADQLQ score was also found to be significantly associated with airway inflammation as measured by FENO (regression coefficient 0.410, 95% CI 0.175-0.646, P=0.001). Additionally, PADQLQ showed a high degree of correlation with symptom scores and quality of life as measured by a VAS, good within-subject reliability and a small minimal important difference (0.20, 95% CI -0.09 to 0.49 on a seven-point scale). Conclusion: HRQL is related to both allergen load and allergic inflammation and the PADQLQ has excellent cross-sectional and longitudinal validity with respect to quality of life and symptoms.

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More information

Published date: 1 October 2005
Keywords: Asthma, Children, Eczema, Multi-system allergic disease, Quality of life, Rhinoconjunctivitis, Teenagers

Identifiers

Local EPrints ID: 445708
URI: http://eprints.soton.ac.uk/id/eprint/445708
ISSN: 0954-7894
PURE UUID: 438abbbc-9e8e-4235-9e45-ee9b1221a45b
ORCID for G. Roberts: ORCID iD orcid.org/0000-0003-2252-1248

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Date deposited: 06 Jan 2021 17:41
Last modified: 18 Feb 2021 17:04

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Contributors

Author: G. Roberts ORCID iD
Author: M. Mylonopoulou
Author: C. Hurley
Author: G. Lack

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