Anxiety in asthma: a systematic review and meta-analysis
Anxiety in asthma: a systematic review and meta-analysis
Background Background: Growing evidence from observational studies indicates a high prevalence of anxiety in asthma. However, prevalence rates of coexisting anxiety symptoms and comorbid anxiety disorders vary widely across studies. We aimed to evaluate the associations between anxiety and asthma and provide more precise comorbidity estimates. Methods We systematically reviewed the literature from case-controlled studies and conducted a meta-analysis to evaluate the pooled prevalence estimates and risks of anxiety symptoms and anxiety disorders in asthma individuals. Screening, data extraction, and quality assessment were undertaken following PRISMA guidelines for preferred reporting of systematic reviews and meta-analysis. A random-effects model was used to calculate pooled prevalence rates. Meta-analysis was conducted using Review Manager 5.3. Multiple databases including PubMed, ScienceDirect, PsychINFO, and PsycARTICLES were searched for publications before 1 December 2019. The review protocol was registered on PROSPERO (ref: CRD42020176028). Results In total, 19 studies involving 106813 participants were included. The pooled prevalence of anxiety symptoms and anxiety disorders in individuals with asthma was 0.32 (95% CI 0.22-0.43) and 0.24 (95% CI 0.13-0.41), respectively. The risks of coexisting anxiety symptoms and comorbid anxiety disorders were significantly higher in asthma patients than in non-asthma controls indicated by OR 1.89 (95% CI 1.42-2.52; Z = 4.37; p < 0.001) and OR 2.08 (95% CI 1.70-2.56; Z = 6.97; p < 0.001), respectively. Anxiety symptoms and anxiety disorders occur at increased frequency among patients with asthma. Conclusions Our findings highlight the need for appropriate assessments for these comorbid conditions, which may help to identify a subgroup of patients who might benefit from interventions designed to reduce anxiety and enhance the quality of life.
Anxiety, asthma, meta-analysis, prevalence, review
11-20
Ye, Gang
fc583a08-c1a8-45d1-a123-527378b71bc2
Baldwin, David
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Hou, Ruihua
470bdcbc-93a9-4dad-aac5-26d455c34376
12 January 2021
Ye, Gang
fc583a08-c1a8-45d1-a123-527378b71bc2
Baldwin, David
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Hou, Ruihua
470bdcbc-93a9-4dad-aac5-26d455c34376
Ye, Gang, Baldwin, David and Hou, Ruihua
(2021)
Anxiety in asthma: a systematic review and meta-analysis.
Psychological Medicine, 51 (1), .
(doi:10.1017/S0033291720005097).
Abstract
Background Background: Growing evidence from observational studies indicates a high prevalence of anxiety in asthma. However, prevalence rates of coexisting anxiety symptoms and comorbid anxiety disorders vary widely across studies. We aimed to evaluate the associations between anxiety and asthma and provide more precise comorbidity estimates. Methods We systematically reviewed the literature from case-controlled studies and conducted a meta-analysis to evaluate the pooled prevalence estimates and risks of anxiety symptoms and anxiety disorders in asthma individuals. Screening, data extraction, and quality assessment were undertaken following PRISMA guidelines for preferred reporting of systematic reviews and meta-analysis. A random-effects model was used to calculate pooled prevalence rates. Meta-analysis was conducted using Review Manager 5.3. Multiple databases including PubMed, ScienceDirect, PsychINFO, and PsycARTICLES were searched for publications before 1 December 2019. The review protocol was registered on PROSPERO (ref: CRD42020176028). Results In total, 19 studies involving 106813 participants were included. The pooled prevalence of anxiety symptoms and anxiety disorders in individuals with asthma was 0.32 (95% CI 0.22-0.43) and 0.24 (95% CI 0.13-0.41), respectively. The risks of coexisting anxiety symptoms and comorbid anxiety disorders were significantly higher in asthma patients than in non-asthma controls indicated by OR 1.89 (95% CI 1.42-2.52; Z = 4.37; p < 0.001) and OR 2.08 (95% CI 1.70-2.56; Z = 6.97; p < 0.001), respectively. Anxiety symptoms and anxiety disorders occur at increased frequency among patients with asthma. Conclusions Our findings highlight the need for appropriate assessments for these comorbid conditions, which may help to identify a subgroup of patients who might benefit from interventions designed to reduce anxiety and enhance the quality of life.
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Accepted/In Press date: 3 December 2020
e-pub ahead of print date: 12 January 2021
Published date: 12 January 2021
Additional Information:
Funding Information:
Acknowledgements. This work was supported by an award from Jiangsu Commission of Health International Exchange Programme grant (Ref: JSH-2019-015).
Publisher Copyright:
Copyright © The Author(s), 2021. Published by Cambridge University Press.
Keywords:
Anxiety, asthma, meta-analysis, prevalence, review
Identifiers
Local EPrints ID: 445755
URI: http://eprints.soton.ac.uk/id/eprint/445755
ISSN: 0033-2917
PURE UUID: 3bab1794-10d1-48d2-8fa2-d65e7119479a
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Date deposited: 07 Jan 2021 17:31
Last modified: 17 Mar 2024 06:10
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Gang Ye
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