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Appendicitis

Appendicitis
Appendicitis

INTRODUCTION: Appendicitis is an inflammation of the appendix that may lead to an abscess, ileus, peritonitis, or death if untreated. Appendicitis is the most common abdominal surgical emergency. The current standard treatment of uncomplicated appendicitis is usually surgery, but there has been increasing evidence published on the use of antibiotics.

METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of surgery compared with antibiotics for acute appendicitis? We searched: Medline, Embase, The Cochrane Library, and other important databases up to May 2014 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).

RESULTS: We found four studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.

CONCLUSIONS: In this systematic review we present information relating to the effectiveness and safety of surgery (including laparoscopic and open appendicectomy) compared with antibiotics.

1752-8526
D'Souza, Nigel
0527b945-cda0-4e14-bc21-126198aa8c2b
Nugent, Karen
79fcb89d-6ff2-47b8-ac2c-2afb24954456
D'Souza, Nigel
0527b945-cda0-4e14-bc21-126198aa8c2b
Nugent, Karen
79fcb89d-6ff2-47b8-ac2c-2afb24954456

D'Souza, Nigel and Nugent, Karen (2014) Appendicitis. BMJ clinical evidence, 2014.

Record type: Review

Abstract

INTRODUCTION: Appendicitis is an inflammation of the appendix that may lead to an abscess, ileus, peritonitis, or death if untreated. Appendicitis is the most common abdominal surgical emergency. The current standard treatment of uncomplicated appendicitis is usually surgery, but there has been increasing evidence published on the use of antibiotics.

METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of surgery compared with antibiotics for acute appendicitis? We searched: Medline, Embase, The Cochrane Library, and other important databases up to May 2014 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).

RESULTS: We found four studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.

CONCLUSIONS: In this systematic review we present information relating to the effectiveness and safety of surgery (including laparoscopic and open appendicectomy) compared with antibiotics.

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More information

Published date: 8 December 2014

Identifiers

Local EPrints ID: 445944
URI: http://eprints.soton.ac.uk/id/eprint/445944
ISSN: 1752-8526
PURE UUID: 51fd74e7-9962-44f0-82e9-7bf387d60b47

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Date deposited: 14 Jan 2021 19:16
Last modified: 05 Jun 2024 19:45

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Contributors

Author: Nigel D'Souza
Author: Karen Nugent

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