Non-alcoholic fatty liver disease: a multisystem disease requiring a multidisciplinary and holistic approach
Non-alcoholic fatty liver disease: a multisystem disease requiring a multidisciplinary and holistic approach
Non-alcoholic fatty liver disease (NAFLD) is a public health problem worldwide. This narrative Review provides an overview of the current literature to support the notion that NAFLD is a multisystem disease. Convincing evidence shows a strong association between NAFLD and the risk of developing multiple extrahepatic complications such as type 2 diabetes, cardiovascular disease (ie, the predominant cause of mortality in people with NAFLD), chronic kidney disease, and some types of extrahepatic malignancies. The magnitude of this risk parallels the severity of NAFLD (especially the stage of liver fibrosis). There are probably multiple underlying mechanisms by which NAFLD might increase the risk of cardiovascular disease, type 2 diabetes, and extrahepatic complications. Addressing the growing burden of NAFLD will require setting up a multidisciplinary working group and framework to progress and embrace novel collaborative ways of working to deliver holistic, person-centred care and management of people with NAFLD.
578-588
Targher, Giovanni
043e0811-b389-4922-974e-22e650212c5f
Tilg, Herbert
eb8f95f4-a99c-4d2c-850b-094c83c5fd64
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
1 July 2021
Targher, Giovanni
043e0811-b389-4922-974e-22e650212c5f
Tilg, Herbert
eb8f95f4-a99c-4d2c-850b-094c83c5fd64
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
Targher, Giovanni, Tilg, Herbert and Byrne, Christopher
(2021)
Non-alcoholic fatty liver disease: a multisystem disease requiring a multidisciplinary and holistic approach.
The Lancet Gastroenterology & Hepatology, 6 (7), .
(doi:10.1016/S2468-1253(21)00020-0).
Abstract
Non-alcoholic fatty liver disease (NAFLD) is a public health problem worldwide. This narrative Review provides an overview of the current literature to support the notion that NAFLD is a multisystem disease. Convincing evidence shows a strong association between NAFLD and the risk of developing multiple extrahepatic complications such as type 2 diabetes, cardiovascular disease (ie, the predominant cause of mortality in people with NAFLD), chronic kidney disease, and some types of extrahepatic malignancies. The magnitude of this risk parallels the severity of NAFLD (especially the stage of liver fibrosis). There are probably multiple underlying mechanisms by which NAFLD might increase the risk of cardiovascular disease, type 2 diabetes, and extrahepatic complications. Addressing the growing burden of NAFLD will require setting up a multidisciplinary working group and framework to progress and embrace novel collaborative ways of working to deliver holistic, person-centred care and management of people with NAFLD.
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Accepted/In Press date: 11 January 2021
e-pub ahead of print date: 4 May 2021
Published date: 1 July 2021
Additional Information:
Funding Information:
GT receives grants from the University of Verona. CDB receives grants from the NIHR Southampton Biomedical Research Centre. HT receives grants from the excellence initiative VASCage (Research Centre of Excellence in Vascular Ageing); a Competence Centers for Excellent Technologies project funded by the Austrian Federal Ministry for Transport, Innovation, and Technology; the Austrian Ministry for Digital and Economic Affairs; and the Federal State of Austria (Tyrol, Salzburg, and Vienna).
Publisher Copyright:
© 2021 Elsevier Ltd
Identifiers
Local EPrints ID: 446010
URI: http://eprints.soton.ac.uk/id/eprint/446010
ISSN: 2468-1253
PURE UUID: d7e22011-b5dc-42f9-9590-6308994fa08c
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Date deposited: 19 Jan 2021 17:30
Last modified: 17 Mar 2024 06:14
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Author:
Giovanni Targher
Author:
Herbert Tilg
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