The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Skeletal stem cell niche of the bone marrow

Skeletal stem cell niche of the bone marrow
Skeletal stem cell niche of the bone marrow
Mammalian bone marrow is a complex organ responsible for a variety of critical homeostatic functions, including haematopoiesis. To achieve these functions, it has evolved to provide an environment for the habitation of stem cells—the bone marrow ‘stem cell niche’. In addition to haematopoetic stem cells, which are responsible for generating all cell lineages of the mammalian blood, recent evidence suggests that this same niche may provide an environment for the putative skeletal stem cell, responsible for forming the connective tissues of the skeleton—bone, cartilage and fat. In this chapter, we review recent research on the importance of skeletal stem cells and bone marrow stromal cells and their spatial localisation within the bone marrow. We discuss their role in providing a supportive microenvironment for the maintenance of haematopoetic stem cells, and some of their key molecular interactions via cell surface ligands, secreted growth factors, extracellular matrix and other physiocochemical means. We also discuss some of the pathologies that might arise from dysregulation of the niche, particularly with regard to ageing. Finally, we review recent attempts to recreate the bone marrow microenvironment in vitro.
245-279
Springer, Cham
Janeczek, Agnieszka Aleksandra
6d713f66-c5fb-40f7-9a7d-17415eb66ec7
Scarpa, Edoardo
2f6eff91-f29f-400e-96c7-e13a307d4203
Newman, Tracey
322290cb-2e9c-445d-a047-00b1bea39a25
Oreffo, Richard
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Tare, Rahul
587c9db4-e409-4e7c-a02a-677547ab724a
Evans, Nicholas
06a05c97-bfed-4abb-9244-34ec9f4b4b95
Turksen, Kursad
Janeczek, Agnieszka Aleksandra
6d713f66-c5fb-40f7-9a7d-17415eb66ec7
Scarpa, Edoardo
2f6eff91-f29f-400e-96c7-e13a307d4203
Newman, Tracey
322290cb-2e9c-445d-a047-00b1bea39a25
Oreffo, Richard
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Tare, Rahul
587c9db4-e409-4e7c-a02a-677547ab724a
Evans, Nicholas
06a05c97-bfed-4abb-9244-34ec9f4b4b95
Turksen, Kursad

Janeczek, Agnieszka Aleksandra, Scarpa, Edoardo, Newman, Tracey, Oreffo, Richard, Tare, Rahul and Evans, Nicholas (2015) Skeletal stem cell niche of the bone marrow. In, Turksen, Kursad (ed.) Tissue-Specific Stem Cell Niche: Stem Cell Biology and Regenerative Medicine. Springer, Cham, pp. 245-279.

Record type: Book Section

Abstract

Mammalian bone marrow is a complex organ responsible for a variety of critical homeostatic functions, including haematopoiesis. To achieve these functions, it has evolved to provide an environment for the habitation of stem cells—the bone marrow ‘stem cell niche’. In addition to haematopoetic stem cells, which are responsible for generating all cell lineages of the mammalian blood, recent evidence suggests that this same niche may provide an environment for the putative skeletal stem cell, responsible for forming the connective tissues of the skeleton—bone, cartilage and fat. In this chapter, we review recent research on the importance of skeletal stem cells and bone marrow stromal cells and their spatial localisation within the bone marrow. We discuss their role in providing a supportive microenvironment for the maintenance of haematopoetic stem cells, and some of their key molecular interactions via cell surface ligands, secreted growth factors, extracellular matrix and other physiocochemical means. We also discuss some of the pathologies that might arise from dysregulation of the niche, particularly with regard to ageing. Finally, we review recent attempts to recreate the bone marrow microenvironment in vitro.

This record has no associated files available for download.

More information

Published date: 6 October 2015

Identifiers

Local EPrints ID: 446069
URI: http://eprints.soton.ac.uk/id/eprint/446069
PURE UUID: d29cad60-b9a1-45cf-a5c3-68ab11403fdc
ORCID for Tracey Newman: ORCID iD orcid.org/0000-0002-3727-9258
ORCID for Richard Oreffo: ORCID iD orcid.org/0000-0001-5995-6726
ORCID for Rahul Tare: ORCID iD orcid.org/0000-0001-8274-8837

Catalogue record

Date deposited: 20 Jan 2021 17:30
Last modified: 18 Feb 2021 17:02

Export record

Contributors

Author: Agnieszka Aleksandra Janeczek
Author: Edoardo Scarpa
Author: Tracey Newman ORCID iD
Author: Richard Oreffo ORCID iD
Author: Rahul Tare ORCID iD
Author: Nicholas Evans
Editor: Kursad Turksen

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×