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Deletion of chromosome 13 detected by conventional cytogenetics is a critical prognostic factor in myeloma

Deletion of chromosome 13 detected by conventional cytogenetics is a critical prognostic factor in myeloma
Deletion of chromosome 13 detected by conventional cytogenetics is a critical prognostic factor in myeloma
In myeloma, the prognostic impact of different strategies used to detect chromosome 13 deletion (Delta13) remains controversial. To address this, we compared conventional cytogenetics and interphase fluorescence in situ hybridization (iFISH) in a large multicenter study (n=794). The ability to obtain abnormal metaphases was associated with a poor prognosis, which was worse if Delta13, p53 deletion or t(4;14) was present, but only Delta13 remained significant on multivariate analysis. Patients with Delta13, by either cytogenetics or iFISH, had a poor prognosis. However, when cases with Delta13 detectable by both cytogenetics and iFISH were separated from those detected by iFISH only, the poor prognosis of iFISH-detectable Delta13 disappeared; their outcome matched that of patients with no detectable Delta13 (P=0.115). Addition of ploidy status to iFISH-Delta13 did not affect the prognostic value of the test. Indeed both cytogenetics and iFISH Delta13 divided both hyperdiploidy and nonhyperdiploidy into two groups with similar prognoses, indicating that the poor prognosis of ploidy is entirely due to its association with Delta13. We conclude that Delta13 detected by metaphase analysis is a critical prognostic factor in myeloma. Absence of Delta13, even in those patients yielding only normal or no metaphases, is associated with a relatively good prognosis.
myeloma, chromosomal abnormality, prognosis, ploidy
0887-6924
1610-1617
Chiecchio, L.
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Protheroe, R.K.M.
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Ibrahim, A.H.
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Cheung, K.L.
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Rudduck, C.
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Dagrada, G.P.
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Cabanas, E.D.
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Parker, T.
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Nightingale, M.
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Wechalekar, A.
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Orchard, K.H.
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Harrison, C.J.
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Cross, N.C.P.
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Morgan, G.J.
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Ross, F.M.
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on behalf of the UK Myeloma Forum
Chiecchio, L.
48f9d8f0-c80c-4486-af21-2cd4a27810bc
Protheroe, R.K.M.
b2c9973f-ccf1-44a4-8e37-e76ee7e8ec0b
Ibrahim, A.H.
1b208180-b957-4c53-95ad-e3c3a41e9377
Cheung, K.L.
38af31e3-3be2-4a35-bcbb-7a6ac11ff9fd
Rudduck, C.
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Dagrada, G.P.
5af7a8c6-2db5-4d7c-8936-e21ada0bfc28
Cabanas, E.D.
0c77bdcf-1330-4710-a0b4-bc88b883a1e8
Parker, T.
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Nightingale, M.
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Wechalekar, A.
b657d03b-5b62-4eee-825f-9231242698cb
Orchard, K.H.
4084be47-ee74-408a-896c-296f2787a261
Harrison, C.J.
9c9f6b47-8bfc-49dd-b156-74539b170291
Cross, N.C.P.
f87650da-b908-4a34-b31b-d62c5f186fe4
Morgan, G.J.
7e5206cc-8a58-410c-9ea5-9022b1532ace
Ross, F.M.
ec0958f8-b992-4e4a-b7e3-c474600390ba

Chiecchio, L., Protheroe, R.K.M., Ibrahim, A.H., Cheung, K.L., Rudduck, C., Dagrada, G.P., Cabanas, E.D., Parker, T., Nightingale, M., Wechalekar, A., Orchard, K.H., Harrison, C.J., Cross, N.C.P., Morgan, G.J. and Ross, F.M. , on behalf of the UK Myeloma Forum (2006) Deletion of chromosome 13 detected by conventional cytogenetics is a critical prognostic factor in myeloma. Leukemia, 20 (9), 1610-1617. (doi:10.1038/sj.leu.2404304).

Record type: Article

Abstract

In myeloma, the prognostic impact of different strategies used to detect chromosome 13 deletion (Delta13) remains controversial. To address this, we compared conventional cytogenetics and interphase fluorescence in situ hybridization (iFISH) in a large multicenter study (n=794). The ability to obtain abnormal metaphases was associated with a poor prognosis, which was worse if Delta13, p53 deletion or t(4;14) was present, but only Delta13 remained significant on multivariate analysis. Patients with Delta13, by either cytogenetics or iFISH, had a poor prognosis. However, when cases with Delta13 detectable by both cytogenetics and iFISH were separated from those detected by iFISH only, the poor prognosis of iFISH-detectable Delta13 disappeared; their outcome matched that of patients with no detectable Delta13 (P=0.115). Addition of ploidy status to iFISH-Delta13 did not affect the prognostic value of the test. Indeed both cytogenetics and iFISH Delta13 divided both hyperdiploidy and nonhyperdiploidy into two groups with similar prognoses, indicating that the poor prognosis of ploidy is entirely due to its association with Delta13. We conclude that Delta13 detected by metaphase analysis is a critical prognostic factor in myeloma. Absence of Delta13, even in those patients yielding only normal or no metaphases, is associated with a relatively good prognosis.

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Published date: 2006
Keywords: myeloma, chromosomal abnormality, prognosis, ploidy

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Local EPrints ID: 44607
URI: https://eprints.soton.ac.uk/id/eprint/44607
ISSN: 0887-6924
PURE UUID: 95e2074f-9bd8-4307-b702-2e215d61411c
ORCID for N.C.P. Cross: ORCID iD orcid.org/0000-0001-5481-2555

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Date deposited: 06 Mar 2007
Last modified: 14 Mar 2019 01:46

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Contributors

Author: L. Chiecchio
Author: R.K.M. Protheroe
Author: A.H. Ibrahim
Author: K.L. Cheung
Author: C. Rudduck
Author: G.P. Dagrada
Author: E.D. Cabanas
Author: T. Parker
Author: M. Nightingale
Author: A. Wechalekar
Author: K.H. Orchard
Author: C.J. Harrison
Author: N.C.P. Cross ORCID iD
Author: G.J. Morgan
Author: F.M. Ross

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