Progress in developing rodent models of age-related macular degeneration (AMD)
Progress in developing rodent models of age-related macular degeneration (AMD)
Age-related macular degeneration (AMD) is the leading cause of irreversible central vision loss, typically affecting individuals from mid-life onwards. Its multifactorial aetiology and the lack of any effective treatments has spurred the development of animal models as research and drug discovery tools. Several rodent models have been developed which recapitulate key features of AMD and provide insights into its underlying pathology. These have contributed to making significant progress in understanding the disease and the identification of novel therapeutic targets. However, a major caveat with existing models is that they do not demonstrate the full disease spectrum. In this review, we outline advances in rodent AMD models from the last decade. These models feature various hallmarks associated with AMD, including oxidative stress, hypoxia, immune dysregulation, genetic mutations and environmental risk factors. The review summarises the methods by which each model was created, its pathological characteristics as well as its relation to the disease in humans.
Age-related macular degeneration, Animal models, Hypoxia, Inflammation, Oxidative stress, Retina, Rodents
Soundara Pandi, Sudha Priya
784c58a0-247a-40a8-b36f-92716605fdf0
Ratnayaka, J. Arjuna
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Lotery, Andrew J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Teeling, Jessica L.
fcde1c8e-e5f8-4747-9f3a-6bdb5cd87d0a
1 February 2021
Soundara Pandi, Sudha Priya
784c58a0-247a-40a8-b36f-92716605fdf0
Ratnayaka, J. Arjuna
002499b8-1a9f-45b6-9539-5ac145799dfd
Lotery, Andrew J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Teeling, Jessica L.
fcde1c8e-e5f8-4747-9f3a-6bdb5cd87d0a
Soundara Pandi, Sudha Priya, Ratnayaka, J. Arjuna, Lotery, Andrew J. and Teeling, Jessica L.
(2021)
Progress in developing rodent models of age-related macular degeneration (AMD).
Experimental Eye Research, 203, [108404].
(doi:10.1016/j.exer.2020.108404).
Abstract
Age-related macular degeneration (AMD) is the leading cause of irreversible central vision loss, typically affecting individuals from mid-life onwards. Its multifactorial aetiology and the lack of any effective treatments has spurred the development of animal models as research and drug discovery tools. Several rodent models have been developed which recapitulate key features of AMD and provide insights into its underlying pathology. These have contributed to making significant progress in understanding the disease and the identification of novel therapeutic targets. However, a major caveat with existing models is that they do not demonstrate the full disease spectrum. In this review, we outline advances in rodent AMD models from the last decade. These models feature various hallmarks associated with AMD, including oxidative stress, hypoxia, immune dysregulation, genetic mutations and environmental risk factors. The review summarises the methods by which each model was created, its pathological characteristics as well as its relation to the disease in humans.
Text
YEXER-D-20-00154_R2
- Accepted Manuscript
More information
Accepted/In Press date: 14 December 2020
e-pub ahead of print date: 17 December 2020
Published date: 1 February 2021
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Publisher Copyright:
© 2020
Keywords:
Age-related macular degeneration, Animal models, Hypoxia, Inflammation, Oxidative stress, Retina, Rodents
Identifiers
Local EPrints ID: 446079
URI: http://eprints.soton.ac.uk/id/eprint/446079
ISSN: 0014-4835
PURE UUID: 1f32423a-1250-48a0-b296-27afe332de28
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Date deposited: 20 Jan 2021 17:31
Last modified: 17 Mar 2024 06:15
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Author:
Sudha Priya Soundara Pandi
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