The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Progress in developing rodent models of age-related macular degeneration (AMD)

Progress in developing rodent models of age-related macular degeneration (AMD)
Progress in developing rodent models of age-related macular degeneration (AMD)
Age-related macular degeneration (AMD) is the leading cause of irreversible central vision loss, typically affecting individuals from mid-life onwards. Its multifactorial aetiology and the lack of any effective treatments has spurred the development of animal models as research and drug discovery tools. Several rodent models have been developed which recapitulate key features of AMD and provide insights into its underlying pathology. These have contributed to making significant progress in understanding the disease and the identification of novel therapeutic targets. However, a major caveat with existing models is that they do not demonstrate the full disease spectrum. In this review, we outline advances in rodent AMD models from the last decade. These models feature various hallmarks associated with AMD, including oxidative stress, hypoxia, immune dysregulation, genetic mutations and environmental risk factors. The review summarises the methods by which each model was created, its pathological characteristics as well as its relation to the disease in humans.
Age-related macular degeneration, Animal models, Hypoxia, Inflammation, Oxidative stress, Retina, Rodents
0014-4835
Soundara Pandi, Sudha Priya
784c58a0-247a-40a8-b36f-92716605fdf0
Ratnayaka, J. Arjuna
002499b8-1a9f-45b6-9539-5ac145799dfd
Lotery, Andrew J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Teeling, Jessica L.
fcde1c8e-e5f8-4747-9f3a-6bdb5cd87d0a
Soundara Pandi, Sudha Priya
784c58a0-247a-40a8-b36f-92716605fdf0
Ratnayaka, J. Arjuna
002499b8-1a9f-45b6-9539-5ac145799dfd
Lotery, Andrew J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Teeling, Jessica L.
fcde1c8e-e5f8-4747-9f3a-6bdb5cd87d0a

Soundara Pandi, Sudha Priya, Ratnayaka, J. Arjuna, Lotery, Andrew J. and Teeling, Jessica L. (2021) Progress in developing rodent models of age-related macular degeneration (AMD). Experimental Eye Research, 203, [108404]. (doi:10.1016/j.exer.2020.108404).

Record type: Article

Abstract

Age-related macular degeneration (AMD) is the leading cause of irreversible central vision loss, typically affecting individuals from mid-life onwards. Its multifactorial aetiology and the lack of any effective treatments has spurred the development of animal models as research and drug discovery tools. Several rodent models have been developed which recapitulate key features of AMD and provide insights into its underlying pathology. These have contributed to making significant progress in understanding the disease and the identification of novel therapeutic targets. However, a major caveat with existing models is that they do not demonstrate the full disease spectrum. In this review, we outline advances in rodent AMD models from the last decade. These models feature various hallmarks associated with AMD, including oxidative stress, hypoxia, immune dysregulation, genetic mutations and environmental risk factors. The review summarises the methods by which each model was created, its pathological characteristics as well as its relation to the disease in humans.

Text
YEXER-D-20-00154_R2 - Accepted Manuscript
Restricted to Repository staff only until 17 December 2021.
Request a copy

More information

Accepted/In Press date: 14 December 2020
e-pub ahead of print date: 17 December 2020
Published date: 1 February 2021
Keywords: Age-related macular degeneration, Animal models, Hypoxia, Inflammation, Oxidative stress, Retina, Rodents

Identifiers

Local EPrints ID: 446079
URI: http://eprints.soton.ac.uk/id/eprint/446079
ISSN: 0014-4835
PURE UUID: 1f32423a-1250-48a0-b296-27afe332de28
ORCID for J. Arjuna Ratnayaka: ORCID iD orcid.org/0000-0002-1027-6938
ORCID for Andrew J. Lotery: ORCID iD orcid.org/0000-0001-5541-4305
ORCID for Jessica L. Teeling: ORCID iD orcid.org/0000-0003-4004-7391

Catalogue record

Date deposited: 20 Jan 2021 17:31
Last modified: 22 Nov 2021 03:05

Export record

Altmetrics

Contributors

Author: Sudha Priya Soundara Pandi

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×