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Time multiplexed active neural probe with 1356 parallel recording sites

Time multiplexed active neural probe with 1356 parallel recording sites
Time multiplexed active neural probe with 1356 parallel recording sites
We present a high electrode density and high channel count CMOS (complementary metal-oxide-semiconductor) active neural probe containing 1344 neuron sized recording pixels (20 µm × 20 µm) and 12 reference pixels (20 µm × 80 µm), densely packed on a 50 µm thick, 100 µm wide, and 8 mm long shank. The active electrodes or pixels consist of dedicated in-situ circuits for signal source amplification, which are directly located under each electrode. The probe supports the simultaneous recording of all 1356 electrodes with sufficient signal to noise ratio for typical neuroscience applications. For enhanced performance, further noise reduction can be achieved while using half of the electrodes (678). Both of these numbers considerably surpass the state-of-the art active neural probes in both electrode count and number of recording channels. The measured input referred noise in the action potential band is 12.4 µVrms, while using 678 electrodes, with just 3 µW power dissipation per pixel and 45 µW per read-out channel (including data transmission).
active electrode, active neural probes, CMOS, high density component, neural amplifier, neural array, neural recording
1424-8220
1-20
Raducanu, Bogdan C.
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Yazicioglu, Refet F.
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Lopez, Carolina M.
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Ballini, Marco
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Putzeys, Jan
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Wang, Shiwei
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Andrei, Alexandru
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Rochus, Veronique
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Welkenhuysen, Marleen
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van Helleputte, Nick
bad8e4b6-6d24-440f-97c3-e1ddeda371f1
Musa, Silke
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Puers, Robert
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Kloosterman, Fabian
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Van Hoof, Chris
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Fiath, Richard
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Ulbert, Istvan
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Mitra, Srinjoy
79aea4eb-3822-45f4-b753-edcef8b41dd6
Raducanu, Bogdan C.
5d2f9b53-93f7-45c0-905e-17be4beb673d
Yazicioglu, Refet F.
7dbc41f6-bf40-4b95-a3fe-6a1fa0c1089f
Lopez, Carolina M.
b7db9e25-fd8b-4d0e-8e91-2e201640a1eb
Ballini, Marco
5ce563dd-6818-4688-b799-1df93ccf5df1
Putzeys, Jan
91ca8966-67bd-4b72-82f6-023b78437154
Wang, Shiwei
97433cb6-7752-4c68-89f8-933f233d8642
Andrei, Alexandru
2e34fd26-3a2d-4857-8dfb-0082be4a40e3
Rochus, Veronique
79c1c3ac-1e90-4303-a73b-8b0777d5f13a
Welkenhuysen, Marleen
3a32f906-55a2-4b9d-bb67-37a71762707e
van Helleputte, Nick
bad8e4b6-6d24-440f-97c3-e1ddeda371f1
Musa, Silke
d84f1a9e-2850-431c-8138-978cc7df8b2f
Puers, Robert
336f78e2-4cc8-4a71-9063-7a1539fb2e13
Kloosterman, Fabian
54e635ab-b042-4610-972c-b56c1b2bfa8a
Van Hoof, Chris
b0815a8d-91b8-4c1f-851c-6b71f5852ff7
Fiath, Richard
26c8dfc1-6287-4ff9-bd70-d1823c329d77
Ulbert, Istvan
c016671c-e25a-4356-8456-b8ffd5682a0e
Mitra, Srinjoy
79aea4eb-3822-45f4-b753-edcef8b41dd6

Raducanu, Bogdan C., Yazicioglu, Refet F., Lopez, Carolina M., Ballini, Marco, Putzeys, Jan, Wang, Shiwei, Andrei, Alexandru, Rochus, Veronique, Welkenhuysen, Marleen, van Helleputte, Nick, Musa, Silke, Puers, Robert, Kloosterman, Fabian, Van Hoof, Chris, Fiath, Richard, Ulbert, Istvan and Mitra, Srinjoy (2017) Time multiplexed active neural probe with 1356 parallel recording sites. Sensors, 17, 1-20. (doi:10.3390/s17102388).

Record type: Article

Abstract

We present a high electrode density and high channel count CMOS (complementary metal-oxide-semiconductor) active neural probe containing 1344 neuron sized recording pixels (20 µm × 20 µm) and 12 reference pixels (20 µm × 80 µm), densely packed on a 50 µm thick, 100 µm wide, and 8 mm long shank. The active electrodes or pixels consist of dedicated in-situ circuits for signal source amplification, which are directly located under each electrode. The probe supports the simultaneous recording of all 1356 electrodes with sufficient signal to noise ratio for typical neuroscience applications. For enhanced performance, further noise reduction can be achieved while using half of the electrodes (678). Both of these numbers considerably surpass the state-of-the art active neural probes in both electrode count and number of recording channels. The measured input referred noise in the action potential band is 12.4 µVrms, while using 678 electrodes, with just 3 µW power dissipation per pixel and 45 µW per read-out channel (including data transmission).

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sensors-17-02388-v2 - Version of Record
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Accepted/In Press date: 16 October 2017
Published date: 19 October 2017
Keywords: active electrode, active neural probes, CMOS, high density component, neural amplifier, neural array, neural recording

Identifiers

Local EPrints ID: 446104
URI: http://eprints.soton.ac.uk/id/eprint/446104
ISSN: 1424-8220
PURE UUID: a89fe3ec-0d13-4e7f-a5dc-b41cf47259ca
ORCID for Shiwei Wang: ORCID iD orcid.org/0000-0002-5450-2108

Catalogue record

Date deposited: 20 Jan 2021 17:32
Last modified: 26 Nov 2021 03:23

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Contributors

Author: Bogdan C. Raducanu
Author: Refet F. Yazicioglu
Author: Carolina M. Lopez
Author: Marco Ballini
Author: Jan Putzeys
Author: Shiwei Wang ORCID iD
Author: Alexandru Andrei
Author: Veronique Rochus
Author: Marleen Welkenhuysen
Author: Nick van Helleputte
Author: Silke Musa
Author: Robert Puers
Author: Fabian Kloosterman
Author: Chris Van Hoof
Author: Richard Fiath
Author: Istvan Ulbert
Author: Srinjoy Mitra

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