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Overexpression of CEBPA resulting from the translocation t(14;19)(q32;q13) of human precursor B acute lymphoblastic leukemia

Overexpression of CEBPA resulting from the translocation t(14;19)(q32;q13) of human precursor B acute lymphoblastic leukemia
Overexpression of CEBPA resulting from the translocation t(14;19)(q32;q13) of human precursor B acute lymphoblastic leukemia
Subtle variation in the expression or function of a small group of transcription factors can drive leukemogenesis. The CEBPA protein is known to regulate the balance between cell proliferation and differentiation during early hematopoietic development and myeloid differentiation. In human myeloid leukemia, CEBPA is frequently inactivated by mutation and indirect and posttranslational mechanisms, in keeping with tumor suppressor properties. We report that CEBPA is activated by juxtaposition to the immunoglobulin gene enhancer upon its rearrangement with the immunoglobulin heavy-chain locus in precursor B-cell acute lymphoblastic leukemia harboring t(14;19)(q32;q13). Overexpression of apparently normal CEBPA RNA or protein was observed in 6 patients. These data indicate that CEBPA may exhibit oncogenic as well as tumor suppressor properties in human leukemogenesis.
0006-4971
3560-3563
Chapiro, Elise
24609666-f32f-4598-a68a-4988e6450c28
Russell, Lisa
a0472729-08df-4ac1-88d4-56dfdf3952d1
Radford-Weiss, Isabelle
4b9c17c6-6578-4e64-aff8-64ae7301a711
Bastard, Christian
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Lessard, Michel
f04f5099-5775-402f-835c-03a1fae74e98
Struski, Stephanie
68409ae5-e0bc-4fba-922f-6ead4935a16f
Cave, Helene
1602ea5e-9016-4c4f-a7e3-9843a0de6d91
Fert-Ferrer, Sandra
26287785-0217-48d4-824d-3bf2029db055
Barin, Carole
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Maarek, Odile
419e2fa0-65cf-4da4-904c-bf525f4c9f48
Della-Valle, Veronique
30cc72ac-0eff-409a-a3e1-7d0132f1aa97
Strefford, Jonathan C.
3782b392-f080-42bf-bdca-8aa5d6ca532f
Berger, Roland
58ebe0fc-b0c0-4d5a-b0ee-60424e750cd0
Harrison, Christine J.
52da7673-509c-4b88-b92e-0c021c9c7d3e
Bernard, Olivier A.
97e5281b-c5a3-460b-8676-0dfb4502db20
Nguyen-Khac, Florence
1bf623af-6c74-4bce-9617-4c6d1ffa4f74
the Groupe Francophone de Cytogénétique Hématologique
Chapiro, Elise
24609666-f32f-4598-a68a-4988e6450c28
Russell, Lisa
a0472729-08df-4ac1-88d4-56dfdf3952d1
Radford-Weiss, Isabelle
4b9c17c6-6578-4e64-aff8-64ae7301a711
Bastard, Christian
7abeb420-19ff-43a3-a939-b3a4d1b0164e
Lessard, Michel
f04f5099-5775-402f-835c-03a1fae74e98
Struski, Stephanie
68409ae5-e0bc-4fba-922f-6ead4935a16f
Cave, Helene
1602ea5e-9016-4c4f-a7e3-9843a0de6d91
Fert-Ferrer, Sandra
26287785-0217-48d4-824d-3bf2029db055
Barin, Carole
3d2270ad-e13c-4924-a0af-8b7c10616aa2
Maarek, Odile
419e2fa0-65cf-4da4-904c-bf525f4c9f48
Della-Valle, Veronique
30cc72ac-0eff-409a-a3e1-7d0132f1aa97
Strefford, Jonathan C.
3782b392-f080-42bf-bdca-8aa5d6ca532f
Berger, Roland
58ebe0fc-b0c0-4d5a-b0ee-60424e750cd0
Harrison, Christine J.
52da7673-509c-4b88-b92e-0c021c9c7d3e
Bernard, Olivier A.
97e5281b-c5a3-460b-8676-0dfb4502db20
Nguyen-Khac, Florence
1bf623af-6c74-4bce-9617-4c6d1ffa4f74

Chapiro, Elise, Russell, Lisa, Radford-Weiss, Isabelle, Bastard, Christian, Lessard, Michel, Struski, Stephanie, Cave, Helene, Fert-Ferrer, Sandra, Barin, Carole, Maarek, Odile, Della-Valle, Veronique, Strefford, Jonathan C., Berger, Roland, Harrison, Christine J., Bernard, Olivier A. and Nguyen-Khac, Florence , the Groupe Francophone de Cytogénétique Hématologique (2006) Overexpression of CEBPA resulting from the translocation t(14;19)(q32;q13) of human precursor B acute lymphoblastic leukemia. Blood, 108 (10), 3560-3563. (doi:10.1182/blood-2006-03-010835).

Record type: Article

Abstract

Subtle variation in the expression or function of a small group of transcription factors can drive leukemogenesis. The CEBPA protein is known to regulate the balance between cell proliferation and differentiation during early hematopoietic development and myeloid differentiation. In human myeloid leukemia, CEBPA is frequently inactivated by mutation and indirect and posttranslational mechanisms, in keeping with tumor suppressor properties. We report that CEBPA is activated by juxtaposition to the immunoglobulin gene enhancer upon its rearrangement with the immunoglobulin heavy-chain locus in precursor B-cell acute lymphoblastic leukemia harboring t(14;19)(q32;q13). Overexpression of apparently normal CEBPA RNA or protein was observed in 6 patients. These data indicate that CEBPA may exhibit oncogenic as well as tumor suppressor properties in human leukemogenesis.

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Published date: 2006

Identifiers

Local EPrints ID: 44617
URI: http://eprints.soton.ac.uk/id/eprint/44617
ISSN: 0006-4971
PURE UUID: ea84f555-4de5-4b3f-831a-f2ee9eee0b29
ORCID for Jonathan C. Strefford: ORCID iD orcid.org/0000-0002-0972-2881

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Date deposited: 02 Mar 2007
Last modified: 17 Dec 2019 01:47

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Contributors

Author: Elise Chapiro
Author: Lisa Russell
Author: Isabelle Radford-Weiss
Author: Christian Bastard
Author: Michel Lessard
Author: Stephanie Struski
Author: Helene Cave
Author: Sandra Fert-Ferrer
Author: Carole Barin
Author: Odile Maarek
Author: Veronique Della-Valle
Author: Roland Berger
Author: Christine J. Harrison
Author: Olivier A. Bernard
Author: Florence Nguyen-Khac

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