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Developmental profile of sleep and its potential impact on daytime functioning from childhood to adulthood in sickle cell anaemia

Developmental profile of sleep and its potential impact on daytime functioning from childhood to adulthood in sickle cell anaemia
Developmental profile of sleep and its potential impact on daytime functioning from childhood to adulthood in sickle cell anaemia

Young individuals with sickle cell anaemia (SCA) experience sleep disturbances and often experience daytime tiredness, which in turn may impact on their daytime functioning and academic attainment, but there are few longitudinal data. Methods: Data on sleep habits and behaviour were taken on the same day as an in‐hospital polysomnography. This study assesses the developmental sleep profiles of children and young adults aged 4–23 years old with SCA. We examined retrospective polysomnography (PSG) and questionnaire data. Results: A total of 256 children with a median age of 10.67 years (130 male) were recruited and 179 returned for PSG 1.80–6.72 years later. Later bedtimes and a decrease in total sleep time (TST) were observed. Sleep disturbances, e.g., parasomnias and night waking, were highest in preschool children and young adults at their first visit. Participants with lower sleep quality, more movement during the night and increased night waking experienced daytime sleepiness, potentially an indicator of lower daytime functioning. Factors influencing sleep quantity included age, hydroxyurea prescription, mean overnight oxygen saturation, sleep onset latency, periodic limb movement, socioeconomic status and night waking. Conclusion: Sleep serves an important role for daytime functioning in SCA; hence, quantitative (i.e., PSG for clinical symptoms, e.g., sleep‐disordered breathing, nocturnal limb movement) and qualitative (i.e., questionnaires for habitual sleep behaviour) assessments of sleep should be mutually considered to guide interventions.

blood disorders, sickle cell anaemia, sleep characteristics, obstructive sleep apnoea, polysomnography, developmental trajectory
2076-3425
Kolbel, Melanie
8cc77aaa-7988-4c96-bdad-7e480a48eea4
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Dimitriou, Dagmara
3b510b78-4c3d-49d9-8960-84450c33c5c9
Kolbel, Melanie
8cc77aaa-7988-4c96-bdad-7e480a48eea4
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Dimitriou, Dagmara
3b510b78-4c3d-49d9-8960-84450c33c5c9

Kolbel, Melanie, Kirkham, Fenella J. and Dimitriou, Dagmara (2020) Developmental profile of sleep and its potential impact on daytime functioning from childhood to adulthood in sickle cell anaemia. Brain Sciences, 10 (12), [981]. (doi:10.3390/brainsci10120981).

Record type: Article

Abstract

Young individuals with sickle cell anaemia (SCA) experience sleep disturbances and often experience daytime tiredness, which in turn may impact on their daytime functioning and academic attainment, but there are few longitudinal data. Methods: Data on sleep habits and behaviour were taken on the same day as an in‐hospital polysomnography. This study assesses the developmental sleep profiles of children and young adults aged 4–23 years old with SCA. We examined retrospective polysomnography (PSG) and questionnaire data. Results: A total of 256 children with a median age of 10.67 years (130 male) were recruited and 179 returned for PSG 1.80–6.72 years later. Later bedtimes and a decrease in total sleep time (TST) were observed. Sleep disturbances, e.g., parasomnias and night waking, were highest in preschool children and young adults at their first visit. Participants with lower sleep quality, more movement during the night and increased night waking experienced daytime sleepiness, potentially an indicator of lower daytime functioning. Factors influencing sleep quantity included age, hydroxyurea prescription, mean overnight oxygen saturation, sleep onset latency, periodic limb movement, socioeconomic status and night waking. Conclusion: Sleep serves an important role for daytime functioning in SCA; hence, quantitative (i.e., PSG for clinical symptoms, e.g., sleep‐disordered breathing, nocturnal limb movement) and qualitative (i.e., questionnaires for habitual sleep behaviour) assessments of sleep should be mutually considered to guide interventions.

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More information

Accepted/In Press date: 11 December 2020
Published date: 14 December 2020
Keywords: blood disorders, sickle cell anaemia, sleep characteristics, obstructive sleep apnoea, polysomnography, developmental trajectory

Identifiers

Local EPrints ID: 446253
URI: http://eprints.soton.ac.uk/id/eprint/446253
ISSN: 2076-3425
PURE UUID: 8d07b31d-9102-4f46-8ecf-25d56429d6c3
ORCID for Fenella J. Kirkham: ORCID iD orcid.org/0000-0002-2443-7958

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Date deposited: 01 Feb 2021 17:32
Last modified: 06 Jun 2024 01:40

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Contributors

Author: Melanie Kolbel
Author: Dagmara Dimitriou

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