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Intake of n-3 polyunsaturated fatty acids in childhood, FADS genotype, and incident asthma

Intake of n-3 polyunsaturated fatty acids in childhood, FADS genotype, and incident asthma
Intake of n-3 polyunsaturated fatty acids in childhood, FADS genotype, and incident asthma
Longitudinal evidence on the relation between dietary intake of n-3 (omega-3) very long-chain polyunsaturated fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in mid-childhood and asthma risk is scarce. We aimed to investigate whether a higher intake of EPA and DHA from fish in childhood is associated with a lower risk of incident asthma.
In the Avon Longitudinal Study of Parents and Children, dietary intakes of EPA and DHA from fish were estimated by food frequency questionnaire at 7 years of age. We used logistic regression, controlling for confounders, to analyse associations between intake of EPA and DHA (quartiles) and incidence of doctor-diagnosed asthma at age 11 or 14 years, and explored potential effect modification by a fatty acid desaturase (FADS) polymorphism (rs1535). Replication was sought in the Swedish BAMSE birth cohort.
There was no evidence of association between intake of EPA plus DHA from fish and incident asthma overall (n=4543). However, when stratified by FADS genotype, the odds ratio (95% confidence interval) comparing top versus bottom quartile amongst the 2025 minor G allele carriers was 0.49 (0.31–0.79) (p-trend 0.006), but no inverse association was observed in the homozygous major A allele group (odds ratio 1.43, 95% confidence interval 0.83–2.46, p-trend 0.19) (p-interaction 0.006). This gene-nutrient interaction on incident asthma was replicated in BAMSE.
In children with a common FADS variant, higher intake of EPA and DHA from fish in childhood was strongly associated with a lower risk of incident asthma up to mid-adolescence.

0903-1936
Talaei, Mohammad
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Sdona, Emmanouela
b870423e-97ca-4012-ba6f-0929af814ce6
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Jones, Louise R.
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Emmett, Pauline M.
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Granell, Raquel
7b3c9487-b8d2-4462-82ac-e4babc9b60c7
Bergström, Anna
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Melén, Erik
2251f526-b320-4636-ab44-6c5fb5bce777
Shaheen, Seif O.
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Talaei, Mohammad
9e7ce2ac-e5e8-47db-bf86-1d9e45d71b5b
Sdona, Emmanouela
b870423e-97ca-4012-ba6f-0929af814ce6
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Jones, Louise R.
0ff894c6-4c44-4a6a-b902-f99d36e9930f
Emmett, Pauline M.
2234adae-ee3b-4093-82f9-20d67b818cb5
Granell, Raquel
7b3c9487-b8d2-4462-82ac-e4babc9b60c7
Bergström, Anna
7f2c3d58-01f8-4dc4-b131-f762d74826b3
Melén, Erik
2251f526-b320-4636-ab44-6c5fb5bce777
Shaheen, Seif O.
06f617c0-968b-49d3-a858-975efb646502

Talaei, Mohammad, Sdona, Emmanouela, Calder, Philip, Jones, Louise R., Emmett, Pauline M., Granell, Raquel, Bergström, Anna, Melén, Erik and Shaheen, Seif O. (2021) Intake of n-3 polyunsaturated fatty acids in childhood, FADS genotype, and incident asthma. European Respiratory Journal. (doi:10.1183/13993003.03633-2020). (In Press)

Record type: Article

Abstract

Longitudinal evidence on the relation between dietary intake of n-3 (omega-3) very long-chain polyunsaturated fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), in mid-childhood and asthma risk is scarce. We aimed to investigate whether a higher intake of EPA and DHA from fish in childhood is associated with a lower risk of incident asthma.
In the Avon Longitudinal Study of Parents and Children, dietary intakes of EPA and DHA from fish were estimated by food frequency questionnaire at 7 years of age. We used logistic regression, controlling for confounders, to analyse associations between intake of EPA and DHA (quartiles) and incidence of doctor-diagnosed asthma at age 11 or 14 years, and explored potential effect modification by a fatty acid desaturase (FADS) polymorphism (rs1535). Replication was sought in the Swedish BAMSE birth cohort.
There was no evidence of association between intake of EPA plus DHA from fish and incident asthma overall (n=4543). However, when stratified by FADS genotype, the odds ratio (95% confidence interval) comparing top versus bottom quartile amongst the 2025 minor G allele carriers was 0.49 (0.31–0.79) (p-trend 0.006), but no inverse association was observed in the homozygous major A allele group (odds ratio 1.43, 95% confidence interval 0.83–2.46, p-trend 0.19) (p-interaction 0.006). This gene-nutrient interaction on incident asthma was replicated in BAMSE.
In children with a common FADS variant, higher intake of EPA and DHA from fish in childhood was strongly associated with a lower risk of incident asthma up to mid-adolescence.

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Accepted/In Press date: 14 January 2021

Identifiers

Local EPrints ID: 446283
URI: http://eprints.soton.ac.uk/id/eprint/446283
ISSN: 0903-1936
PURE UUID: 7c94255c-8d12-48ed-869f-04074953c524
ORCID for Philip Calder: ORCID iD orcid.org/0000-0002-6038-710X

Catalogue record

Date deposited: 03 Feb 2021 17:35
Last modified: 11 Mar 2021 02:36

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Contributors

Author: Mohammad Talaei
Author: Emmanouela Sdona
Author: Philip Calder ORCID iD
Author: Louise R. Jones
Author: Pauline M. Emmett
Author: Raquel Granell
Author: Anna Bergström
Author: Erik Melén
Author: Seif O. Shaheen

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