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Factors influencing symptom expression in children with bronchial hyperresponsiveness at 10 years of age

Factors influencing symptom expression in children with bronchial hyperresponsiveness at 10 years of age
Factors influencing symptom expression in children with bronchial hyperresponsiveness at 10 years of age
OBJECTIVES: We sought to identify factors associated with wheezing symptoms in children found to have bronchial hyperresponsiveness (BHR) at 10 years of age. METHODS: Children were seen at birth, 1, 2, 4 and 10 years of age in an entire population birth cohort study (n = 1456). At each stage information was collected prospectively on genetic and environmental risk factors for BHR. Skin prick testing was performed at 4 and 10 years of age. Spirometry and methacholine bronchial challenge were conducted at 10 years of age when BHR was considered present if PC(20) FEV(1) was < 4.0 mg/mL. In children with BHR at 10 years of age, factors independently associated with current wheezing were determined by logistic regression. RESULTS: BHR was identified in 169 10-year-olds at bronchial challenge, 55.6% of whom manifested current wheeze. In children with BHR, current wheezers had higher Log(10) total IgE and greater BHR than those who had never wheezed. Symptomatic BHR was independently associated with atopic sensitization (P <.001) and maternal asthma (P =.011) at 10 years of age. If only factors present in the first 4 years of life were considered, parental smoking at 4 years of age (P =.021), maternal asthma (P =.017), and atopic sensitization at 4 years of age (P =.004) were independently associated with symptomatic BHR at 10 years of age. CONCLUSIONS: Symptomatic BHR is associated with greater degrees of BHR and higher total IgE. Heredity, atopy, and environmental exposure might influence symptom expression in children with BHR.
asthma, atopy, bronchial hyperresponsiveness, childhoodwheezing, risk factors
0091-6749
311-316
Kurukulaaratchy, Ramesh J.
9c7b8105-2892-49f2-8775-54d4961e3e74
Matthews, Sharon
da71ceaa-c974-4fda-aea0-13c7cdecaf04
Waterhouse, Linda
57cb29f8-9cc2-4c42-8752-f119751250f1
Arshad, S. Hasan
917e246d-2e60-472f-8d30-94b01ef28958
Kurukulaaratchy, Ramesh J.
9c7b8105-2892-49f2-8775-54d4961e3e74
Matthews, Sharon
da71ceaa-c974-4fda-aea0-13c7cdecaf04
Waterhouse, Linda
57cb29f8-9cc2-4c42-8752-f119751250f1
Arshad, S. Hasan
917e246d-2e60-472f-8d30-94b01ef28958

Kurukulaaratchy, Ramesh J., Matthews, Sharon, Waterhouse, Linda and Arshad, S. Hasan (2003) Factors influencing symptom expression in children with bronchial hyperresponsiveness at 10 years of age. Journal of Allergy and Clinical Immunology, 112 (2), 311-316. (doi:10.1067/mai.2003.1623).

Record type: Article

Abstract

OBJECTIVES: We sought to identify factors associated with wheezing symptoms in children found to have bronchial hyperresponsiveness (BHR) at 10 years of age. METHODS: Children were seen at birth, 1, 2, 4 and 10 years of age in an entire population birth cohort study (n = 1456). At each stage information was collected prospectively on genetic and environmental risk factors for BHR. Skin prick testing was performed at 4 and 10 years of age. Spirometry and methacholine bronchial challenge were conducted at 10 years of age when BHR was considered present if PC(20) FEV(1) was < 4.0 mg/mL. In children with BHR at 10 years of age, factors independently associated with current wheezing were determined by logistic regression. RESULTS: BHR was identified in 169 10-year-olds at bronchial challenge, 55.6% of whom manifested current wheeze. In children with BHR, current wheezers had higher Log(10) total IgE and greater BHR than those who had never wheezed. Symptomatic BHR was independently associated with atopic sensitization (P <.001) and maternal asthma (P =.011) at 10 years of age. If only factors present in the first 4 years of life were considered, parental smoking at 4 years of age (P =.021), maternal asthma (P =.017), and atopic sensitization at 4 years of age (P =.004) were independently associated with symptomatic BHR at 10 years of age. CONCLUSIONS: Symptomatic BHR is associated with greater degrees of BHR and higher total IgE. Heredity, atopy, and environmental exposure might influence symptom expression in children with BHR.

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More information

e-pub ahead of print date: 9 August 2003
Keywords: asthma, atopy, bronchial hyperresponsiveness, childhoodwheezing, risk factors

Identifiers

Local EPrints ID: 44630
URI: http://eprints.soton.ac.uk/id/eprint/44630
ISSN: 0091-6749
PURE UUID: 4ab09adf-7215-40c0-9272-ddc9b2dd2d34
ORCID for Ramesh J. Kurukulaaratchy: ORCID iD orcid.org/0000-0002-1588-2400

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Date deposited: 05 Mar 2007
Last modified: 18 Feb 2021 16:54

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