The University of Southampton
University of Southampton Institutional Repository

Prevention of allergic disease during childhood by allergen avoidance: the Isle of Wight prevention study

Arshad, Syed Hasan, Bateman, Belinda, Sadeghnejad, Alireza, Gant, Carole and Matthews, Sharon M. (2007) Prevention of allergic disease during childhood by allergen avoidance: the Isle of Wight prevention study Journal of Allergy and Clinical Immunology, 119, (2), pp. 307-313. (doi:10.1016/j.jaci.2006.12.621).

Record type: Article


BACKGROUND: Early life allergen exposure may increase the risk of childhood allergy, but the protective effect of reduction in allergen exposure remains uncertain. OBJECTIVE: To evaluate the effect of reduction in food and house dust mite (HDM) allergen exposure in infancy in preventing asthma and allergy. METHODS: Infants, at higher risk because of family predisposition, were recruited prenatally and randomized to prophylactic (n = 58) and control (n = 62) groups. Prophylactic group infants were either breast-fed with mother on a low allergen diet or given an extensively hydrolyzed formula. Exposure to HDM was reduced by the use of an acaricide and mattress covers. The control group followed standard advice. Development of allergic diseases and sensitization to common allergens (atopy) was assessed blindly at ages 1, 2, 4, and 8 years in all 120 children. RESULTS: Repeated measurement analysis, adjusted for all relevant confounding variables, confirmed a preventive effect on asthma: adjusted odds ratio (OR), 0.24; 95% CI, 0.09-0.66; P = .005; atopic dermatitis, OR, 0.23; CI, 0.08-0.64; P = .005; rhinitis, OR, 0.42; CI, 0.19-0.92; P = .03; and atopy, OR, 0.13; CI, 0.05-0.32; P < .001. The protective effect was primarily observed in the subgroup of children with persistent disease (symptoms at all visits) and in those with evidence of allergic sensitization. CONCLUSION: Allergic diseases can be reduced, for at least the first 8 years of life, by combined food and HDM allergen avoidance in infancy. CLINICAL IMPLICATIONS: Strict food and HDM allergen avoidance should be considered for prevention of allergy in high-risk infants.

Full text not available from this repository.

More information

Published date: 2007
Keywords: atopy, allergy, asthma, rhinitis, atopic dermatitis, food allergy, prevention, diet, house dust mite, randomized controlled trial


Local EPrints ID: 44633
ISSN: 0091-6749
PURE UUID: 42e47e39-8808-45d8-90ad-2823b4e8fc11

Catalogue record

Date deposited: 05 Mar 2007
Last modified: 17 Jul 2017 15:14

Export record



Author: Belinda Bateman
Author: Alireza Sadeghnejad
Author: Carole Gant
Author: Sharon M. Matthews

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.