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The prevalence, characteristics of and early life risk factors for eczema in 10-year-old children

The prevalence, characteristics of and early life risk factors for eczema in 10-year-old children
The prevalence, characteristics of and early life risk factors for eczema in 10-year-old children

Eczema is a common infantile disease but its nature and extent during later childhood remains unclear. In a whole-population birth cohort study (n = 1456) we examined prevalence and characteristics of eczema amongst 10-year-old children. At this age 1373 (94%) children completed ISAAC questionnaires, 1043 (72%) skin prick testing and 953 (65%) serum inhalant IgE antibody screening. At 10 years of age prevalence of eczema ever was 41.0% and for current eczema was 13.7% (combined current itchy rash and eczema ever). Most current eczema (71.0%) began before 4 years of age, but was associated with low morbidity at 10 years. Amongst children with diagnosed eczema at 4 years of age, 56.3% had current eczema at 10 years. Atopy (positive skin test) and other allergic states were associated with current eczema (p < 0.001). Risk factor analysis for current eczema identified independent significance for atopy (p = 0.01), rhinitis (p = 0.04) and food allergy (p = 0.01) at 4 years, plus maternal asthma (p = 0.03). Diagnosed rhinitis at 4 years emerged as a significant predictor of persistent disease. Eczema is not simply a transient infantile condition but a common problem at 10 years of age, often reflecting persistent disease from early childhood. Inherited predisposition towards atopy is the predominant risk factor for this state.

Child, Eczema/epidemiology, Female, Humans, Hypersensitivity/genetics, Immunoglobulin E, Logistic Models, Male, Prevalence, Prospective Studies, Risk Factors, Surveys and Questionnaires, United Kingdom/epidemiology
0905-6157
178-183
Kurukulaaratchy, Ramesh
9c7b8105-2892-49f2-8775-54d4961e3e74
Fenn, Monica
8fe24028-c9e6-465d-ba76-78b5a1fb129f
Matthews, Sharon
da71ceaa-c974-4fda-aea0-13c7cdecaf04
Hasan Arshad, S
917e246d-2e60-472f-8d30-94b01ef28958
Kurukulaaratchy, Ramesh
9c7b8105-2892-49f2-8775-54d4961e3e74
Fenn, Monica
8fe24028-c9e6-465d-ba76-78b5a1fb129f
Matthews, Sharon
da71ceaa-c974-4fda-aea0-13c7cdecaf04
Hasan Arshad, S
917e246d-2e60-472f-8d30-94b01ef28958

Kurukulaaratchy, Ramesh, Fenn, Monica, Matthews, Sharon and Hasan Arshad, S (2003) The prevalence, characteristics of and early life risk factors for eczema in 10-year-old children. Pediatric Allergy and Immunology, 14 (3), 178-183. (doi:10.1034/j.1399-3038.2003.00036.x).

Record type: Article

Abstract

Eczema is a common infantile disease but its nature and extent during later childhood remains unclear. In a whole-population birth cohort study (n = 1456) we examined prevalence and characteristics of eczema amongst 10-year-old children. At this age 1373 (94%) children completed ISAAC questionnaires, 1043 (72%) skin prick testing and 953 (65%) serum inhalant IgE antibody screening. At 10 years of age prevalence of eczema ever was 41.0% and for current eczema was 13.7% (combined current itchy rash and eczema ever). Most current eczema (71.0%) began before 4 years of age, but was associated with low morbidity at 10 years. Amongst children with diagnosed eczema at 4 years of age, 56.3% had current eczema at 10 years. Atopy (positive skin test) and other allergic states were associated with current eczema (p < 0.001). Risk factor analysis for current eczema identified independent significance for atopy (p = 0.01), rhinitis (p = 0.04) and food allergy (p = 0.01) at 4 years, plus maternal asthma (p = 0.03). Diagnosed rhinitis at 4 years emerged as a significant predictor of persistent disease. Eczema is not simply a transient infantile condition but a common problem at 10 years of age, often reflecting persistent disease from early childhood. Inherited predisposition towards atopy is the predominant risk factor for this state.

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More information

Published date: 2 June 2003
Keywords: Child, Eczema/epidemiology, Female, Humans, Hypersensitivity/genetics, Immunoglobulin E, Logistic Models, Male, Prevalence, Prospective Studies, Risk Factors, Surveys and Questionnaires, United Kingdom/epidemiology

Identifiers

Local EPrints ID: 446441
URI: http://eprints.soton.ac.uk/id/eprint/446441
ISSN: 0905-6157
PURE UUID: 8108440e-43a3-4d5c-ae9e-693eb45ab25c
ORCID for Ramesh Kurukulaaratchy: ORCID iD orcid.org/0000-0002-1588-2400

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Date deposited: 10 Feb 2021 17:30
Last modified: 18 Feb 2021 16:54

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Contributors

Author: Monica Fenn
Author: Sharon Matthews
Author: S Hasan Arshad

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