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Raised cord serum immunoglobulin E increases the risk of allergic sensitisation at ages 4 and 10 and asthma at age 10

Raised cord serum immunoglobulin E increases the risk of allergic sensitisation at ages 4 and 10 and asthma at age 10
Raised cord serum immunoglobulin E increases the risk of allergic sensitisation at ages 4 and 10 and asthma at age 10

BACKGROUND: Evidence suggests that a raised level of cord serum IgE (CS-IgE) is a risk factor for allergic sensitisation. However, whether CS-IgE is a risk for asthma is controversial. A study was undertaken to investigate the association between CS-IgE levels and allergic sensitisation at 4 and 10 years of age and asthma at ages 1-2, 4 and 10.

METHODS: CS-IgE was available for 1358 of 1456 children born between 1989 and 1990. The cohort was evaluated for allergic diseases at ages 1, 2, 4 and 10 years. Skin prick tests for six allergens were performed on 981 children at age 4 and 1036 at age 10. Asthma was defined based on a physician's diagnosis. Using logistic regression analysis, the risk of asthma and allergic sensitisation for raised levels of CS-IgE (> or =0.5 kU/l) was estimated.

RESULTS: At ages 4 and 10 years 20.2% and 27.0% of children, respectively, had allergic sensitisation. The risk of allergic sensitisation was significantly associated with raised CS-IgE levels at ages 4 (OR 2.29) and 10 years (OR 1.73). The prevalence of asthma was 10.3% at age 1-2, 15.2% at age 4, and 12.8% at age 10. CS-IgE was not associated with asthma at age 1-2 and 4 but showed an increased relative risk at age 10 (OR 1.66, 95% CI 1.05 to 2.62). The association was stronger in children who did not develop allergic sensitisation at age 4 or 10 (OR 3.35, 95% CI 1.41 to 7.93).

CONCLUSIONS: Raised cord serum IgE is a risk factor for allergic sensitisation at ages 4 and 10 years. This is the second study suggesting that CS-IgE is also a risk factor for asthma at age 10, probably related to the late onset of asthma. This association is not necessarily mediated by allergic sensitisation.

Asthma/blood, Child, Child, Preschool, Female, Fetal Blood/chemistry, Humans, Hypersensitivity/blood, Immunoglobulin E/blood, Male, Risk Factors, Skin Tests
0040-6376
936-42
Sadeghnejad, A.
0bfc6d30-ecd3-405b-8dc9-7d2532496326
Karmaus, W.
2fb26f2a-c8ef-468a-9688-b4c25c19f284
Davis, S.
59eccbaf-0d14-455d-9554-9ec00b6ee4cd
Kurukulaaratchy, R. J.
9c7b8105-2892-49f2-8775-54d4961e3e74
Arshad, S. H.
917e246d-2e60-472f-8d30-94b01ef28958
Sadeghnejad, A.
0bfc6d30-ecd3-405b-8dc9-7d2532496326
Karmaus, W.
2fb26f2a-c8ef-468a-9688-b4c25c19f284
Davis, S.
59eccbaf-0d14-455d-9554-9ec00b6ee4cd
Kurukulaaratchy, R. J.
9c7b8105-2892-49f2-8775-54d4961e3e74
Arshad, S. H.
917e246d-2e60-472f-8d30-94b01ef28958

Sadeghnejad, A., Karmaus, W., Davis, S., Kurukulaaratchy, R. J. and Arshad, S. H. (2004) Raised cord serum immunoglobulin E increases the risk of allergic sensitisation at ages 4 and 10 and asthma at age 10. Thorax, 59 (11), 936-42. (doi:10.1136/thx.2004.024224).

Record type: Article

Abstract

BACKGROUND: Evidence suggests that a raised level of cord serum IgE (CS-IgE) is a risk factor for allergic sensitisation. However, whether CS-IgE is a risk for asthma is controversial. A study was undertaken to investigate the association between CS-IgE levels and allergic sensitisation at 4 and 10 years of age and asthma at ages 1-2, 4 and 10.

METHODS: CS-IgE was available for 1358 of 1456 children born between 1989 and 1990. The cohort was evaluated for allergic diseases at ages 1, 2, 4 and 10 years. Skin prick tests for six allergens were performed on 981 children at age 4 and 1036 at age 10. Asthma was defined based on a physician's diagnosis. Using logistic regression analysis, the risk of asthma and allergic sensitisation for raised levels of CS-IgE (> or =0.5 kU/l) was estimated.

RESULTS: At ages 4 and 10 years 20.2% and 27.0% of children, respectively, had allergic sensitisation. The risk of allergic sensitisation was significantly associated with raised CS-IgE levels at ages 4 (OR 2.29) and 10 years (OR 1.73). The prevalence of asthma was 10.3% at age 1-2, 15.2% at age 4, and 12.8% at age 10. CS-IgE was not associated with asthma at age 1-2 and 4 but showed an increased relative risk at age 10 (OR 1.66, 95% CI 1.05 to 2.62). The association was stronger in children who did not develop allergic sensitisation at age 4 or 10 (OR 3.35, 95% CI 1.41 to 7.93).

CONCLUSIONS: Raised cord serum IgE is a risk factor for allergic sensitisation at ages 4 and 10 years. This is the second study suggesting that CS-IgE is also a risk factor for asthma at age 10, probably related to the late onset of asthma. This association is not necessarily mediated by allergic sensitisation.

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More information

Accepted/In Press date: 24 August 2004
Published date: 29 October 2004
Keywords: Asthma/blood, Child, Child, Preschool, Female, Fetal Blood/chemistry, Humans, Hypersensitivity/blood, Immunoglobulin E/blood, Male, Risk Factors, Skin Tests

Identifiers

Local EPrints ID: 446465
URI: http://eprints.soton.ac.uk/id/eprint/446465
ISSN: 0040-6376
PURE UUID: a9a103cb-9b3c-4b4c-9db0-972cc6f56aee
ORCID for R. J. Kurukulaaratchy: ORCID iD orcid.org/0000-0002-1588-2400

Catalogue record

Date deposited: 10 Feb 2021 17:35
Last modified: 18 Feb 2021 16:54

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Contributors

Author: A. Sadeghnejad
Author: W. Karmaus
Author: S. Davis
Author: S. H. Arshad

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