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Recognising the risk of aspirin-sensitive respiratory disease in a patient with asthma who has previously tolerated aspirin

Recognising the risk of aspirin-sensitive respiratory disease in a patient with asthma who has previously tolerated aspirin
Recognising the risk of aspirin-sensitive respiratory disease in a patient with asthma who has previously tolerated aspirin
Asthma is a common chronic condition composed of numerous different phenotypes. One clinically relevant phenotype is that of aspirin-sensitive respiratory disease (ASRD) which is more frequently seen in patients with difficult asthma. Reliance on a history of previous reaction to non-steroidal anti-inflammatory drugs (NSAIDs) in order to diagnose ASRD may give false reassurance. We describe the case of a 58-year old man with late onset asthma who was suspected to have ASRD on the basis of associated clinical features despite having taken aspirin safely in the past. The diagnosis of ASRD was subsequently confirmed by an inadvertent aspirin challenge which led to a serious adverse asthma outcome.
Anti-Inflammatory Agents, Non-Steroidal/adverse effects, Aspirin/adverse effects, Asthma/drug therapy, Drug Hypersensitivity/diagnosis, Drug Tolerance, Humans, Male, Middle Aged, Respiratory Tract Diseases/chemically induced
1471-4418
214-217
Abayaratne, Damita
a95c2afe-3acd-4d92-9f7d-cbb4e4cfff14
Kurukulaaratchy, Ramesh J.
9c7b8105-2892-49f2-8775-54d4961e3e74
Abayaratne, Damita
a95c2afe-3acd-4d92-9f7d-cbb4e4cfff14
Kurukulaaratchy, Ramesh J.
9c7b8105-2892-49f2-8775-54d4961e3e74

Abayaratne, Damita and Kurukulaaratchy, Ramesh J. (2011) Recognising the risk of aspirin-sensitive respiratory disease in a patient with asthma who has previously tolerated aspirin. Primary Care Respiratory Journal, 20 (2), 214-217. (doi:10.4104/pcrj.2011.00001).

Record type: Article

Abstract

Asthma is a common chronic condition composed of numerous different phenotypes. One clinically relevant phenotype is that of aspirin-sensitive respiratory disease (ASRD) which is more frequently seen in patients with difficult asthma. Reliance on a history of previous reaction to non-steroidal anti-inflammatory drugs (NSAIDs) in order to diagnose ASRD may give false reassurance. We describe the case of a 58-year old man with late onset asthma who was suspected to have ASRD on the basis of associated clinical features despite having taken aspirin safely in the past. The diagnosis of ASRD was subsequently confirmed by an inadvertent aspirin challenge which led to a serious adverse asthma outcome.

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More information

Published date: 10 February 2011
Keywords: Anti-Inflammatory Agents, Non-Steroidal/adverse effects, Aspirin/adverse effects, Asthma/drug therapy, Drug Hypersensitivity/diagnosis, Drug Tolerance, Humans, Male, Middle Aged, Respiratory Tract Diseases/chemically induced

Identifiers

Local EPrints ID: 446497
URI: http://eprints.soton.ac.uk/id/eprint/446497
ISSN: 1471-4418
PURE UUID: f3d10069-9770-49d2-9b1e-44a5a7c20ac2
ORCID for Ramesh J. Kurukulaaratchy: ORCID iD orcid.org/0000-0002-1588-2400

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Date deposited: 11 Feb 2021 17:34
Last modified: 18 Feb 2021 16:54

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Author: Damita Abayaratne

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