Recognising the risk of aspirin-sensitive respiratory disease in a patient with asthma who has previously tolerated aspirin
Recognising the risk of aspirin-sensitive respiratory disease in a patient with asthma who has previously tolerated aspirin
Asthma is a common chronic condition composed of numerous different phenotypes. One clinically relevant phenotype is that of aspirin-sensitive respiratory disease (ASRD) which is more frequently seen in patients with difficult asthma. Reliance on a history of previous reaction to non-steroidal anti-inflammatory drugs (NSAIDs) in order to diagnose ASRD may give false reassurance. We describe the case of a 58-year old man with late onset asthma who was suspected to have ASRD on the basis of associated clinical features despite having taken aspirin safely in the past. The diagnosis of ASRD was subsequently confirmed by an inadvertent aspirin challenge which led to a serious adverse asthma outcome.
Anti-Inflammatory Agents, Non-Steroidal/adverse effects, Aspirin/adverse effects, Asthma/drug therapy, Drug Hypersensitivity/diagnosis, Drug Tolerance, Humans, Male, Middle Aged, Respiratory Tract Diseases/chemically induced
214-217
Abayaratne, Damita
a95c2afe-3acd-4d92-9f7d-cbb4e4cfff14
Kurukulaaratchy, Ramesh J.
9c7b8105-2892-49f2-8775-54d4961e3e74
10 February 2011
Abayaratne, Damita
a95c2afe-3acd-4d92-9f7d-cbb4e4cfff14
Kurukulaaratchy, Ramesh J.
9c7b8105-2892-49f2-8775-54d4961e3e74
Abayaratne, Damita and Kurukulaaratchy, Ramesh J.
(2011)
Recognising the risk of aspirin-sensitive respiratory disease in a patient with asthma who has previously tolerated aspirin.
Primary Care Respiratory Journal, 20 (2), .
(doi:10.4104/pcrj.2011.00001).
Abstract
Asthma is a common chronic condition composed of numerous different phenotypes. One clinically relevant phenotype is that of aspirin-sensitive respiratory disease (ASRD) which is more frequently seen in patients with difficult asthma. Reliance on a history of previous reaction to non-steroidal anti-inflammatory drugs (NSAIDs) in order to diagnose ASRD may give false reassurance. We describe the case of a 58-year old man with late onset asthma who was suspected to have ASRD on the basis of associated clinical features despite having taken aspirin safely in the past. The diagnosis of ASRD was subsequently confirmed by an inadvertent aspirin challenge which led to a serious adverse asthma outcome.
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Published date: 10 February 2011
Keywords:
Anti-Inflammatory Agents, Non-Steroidal/adverse effects, Aspirin/adverse effects, Asthma/drug therapy, Drug Hypersensitivity/diagnosis, Drug Tolerance, Humans, Male, Middle Aged, Respiratory Tract Diseases/chemically induced
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Local EPrints ID: 446497
URI: http://eprints.soton.ac.uk/id/eprint/446497
ISSN: 1471-4418
PURE UUID: f3d10069-9770-49d2-9b1e-44a5a7c20ac2
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Date deposited: 11 Feb 2021 17:34
Last modified: 17 Mar 2024 02:49
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Author:
Damita Abayaratne
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