The USP7 protein interaction network and its roles in tumorigenesis

Ubiquitin-specific protease (USP7), also known as Herpesvirus-associated ubiquitin-specific protease (HAUSP), is a deubiquitinase. There has been significant recent attention on USP7 following the discovery that USP7 is a key regulator of the p53-MDM2 pathway. The USP7 protein is 130 kDa in size and has multiple domains which bind to a diverse set of proteins. These interactions mediate key developmental and homeostatic processes including the cell cycle, immune response, and modulation of transcription factor and epigenetic regulator activity and localization. USP7 also promotes carcinogenesis through aberrant activation of the Wnt signalling pathway and stabilization of HIF-1α. These findings have shown that USP7 may induce tumour progression and be a therapeutic target. Together with interest in developing USP7 as a target, several studies have defined new protein interactions and the regulatory networks within which USP7 functions. In this review, we focus on the protein interactions of USP7 that are most important for its cancer-associated roles.

Cancer, Deubiquitinase, Protein network, Protein-protein interaction, Proteomics, USP7

10.1016/j.gendis.2020.10.004

41-50

Al-Eidan, Ahood

556ad339-b121-42e1-b873-ac99f905c774

Wang, Yihua

f5044a95-60a7-42d2-87d6-5f1f789e3a7e

Skipp, Paul

1ba7dcf6-9fe7-4b5c-a9d0-e32ed7f42aa5

Ewing, Rob M.

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1 January 2022