Glucose regulation and grip strength in adults: findings from the Helsinki Birth Cohort Study
Glucose regulation and grip strength in adults: findings from the Helsinki Birth Cohort Study
Aim: this study aimed to assess the association between grip strength and glucose regulation in a cross-sectional setting.
Methods: using data from the Helsinki Birth Cohort Study, 924 men and 953 women were studied at a mean age of 61.6 years. Grip strength was assessed in the dominant hand using a Newtest Grip Force dynamometer. A standard 2-h 75 g oral glucose tolerance test (OGTT) was used to define glucose regulation. The participants were classified into four groups: normoglycaemia, prediabetes (impaired fasting glucose or impaired glucose tolerance), newly diagnosed diabetes and previously known diabetes. The association between grip strength and glucose regulation was assessed using multiple linear regression models.
Results: prediabetes was diagnosed in 32.2% and diabetes in 8.4% using the OGTT. A total of 7.8% of the individuals had previously known diabetes. Compared to individuals with normoglycaemia, grip strength was lower for those with newly diagnosed diabetes (-1.8 kg, 95% CI -3.2 to -0.5) as well as those with previously known diabetes (-1.8 kg, 95% CI -3.2 to -0.4) after adjusting for covariates (age, sex, body mass index, physical activity, education and smoking). No difference in grip strength was found when comparing those with prediabetes and normoglycaemia.
Conclusion: in adults, grip strength was lower among those with known and newly diagnosed diabetes compared to those with normoglycaemia. Together with previous findings on associations between grip strength and chronic diseases, these results support the use of grip strength as an overall health marker in adults.
Diabetes mellitus, Epidemiology, Grip strength, Physical fitness, Prediabetes
Astrom, Max J.
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von Bonsdorff, Mikaela B.
85cb5f12-9e2e-4069-ba39-a2d1f08d5fc0
Salonen, Minna K.
afeb1f26-cc79-4b5f-a5e5-6bc490150047
Kajantie, Eero
c1db7428-b2c0-46f9-92c3-bcd8cdd452fd
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Eriksson, Johan G.
eb96b1c5-af07-4a52-8a73-7541451d32cd
1 May 2021
Astrom, Max J.
a64ea085-fb89-447c-aa24-ba63d6ea2c2d
von Bonsdorff, Mikaela B.
85cb5f12-9e2e-4069-ba39-a2d1f08d5fc0
Salonen, Minna K.
afeb1f26-cc79-4b5f-a5e5-6bc490150047
Kajantie, Eero
c1db7428-b2c0-46f9-92c3-bcd8cdd452fd
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Eriksson, Johan G.
eb96b1c5-af07-4a52-8a73-7541451d32cd
Astrom, Max J., von Bonsdorff, Mikaela B., Salonen, Minna K., Kajantie, Eero, Osmond, Clive and Eriksson, Johan G.
(2021)
Glucose regulation and grip strength in adults: findings from the Helsinki Birth Cohort Study.
Archives of Gerontology and Geriatrics, 94, [104348].
(doi:10.1016/j.archger.2021.104348).
Abstract
Aim: this study aimed to assess the association between grip strength and glucose regulation in a cross-sectional setting.
Methods: using data from the Helsinki Birth Cohort Study, 924 men and 953 women were studied at a mean age of 61.6 years. Grip strength was assessed in the dominant hand using a Newtest Grip Force dynamometer. A standard 2-h 75 g oral glucose tolerance test (OGTT) was used to define glucose regulation. The participants were classified into four groups: normoglycaemia, prediabetes (impaired fasting glucose or impaired glucose tolerance), newly diagnosed diabetes and previously known diabetes. The association between grip strength and glucose regulation was assessed using multiple linear regression models.
Results: prediabetes was diagnosed in 32.2% and diabetes in 8.4% using the OGTT. A total of 7.8% of the individuals had previously known diabetes. Compared to individuals with normoglycaemia, grip strength was lower for those with newly diagnosed diabetes (-1.8 kg, 95% CI -3.2 to -0.5) as well as those with previously known diabetes (-1.8 kg, 95% CI -3.2 to -0.4) after adjusting for covariates (age, sex, body mass index, physical activity, education and smoking). No difference in grip strength was found when comparing those with prediabetes and normoglycaemia.
Conclusion: in adults, grip strength was lower among those with known and newly diagnosed diabetes compared to those with normoglycaemia. Together with previous findings on associations between grip strength and chronic diseases, these results support the use of grip strength as an overall health marker in adults.
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GlucoseReg_GripStr_ArchGerontolGeriatr_unmarked_R2
- Accepted Manuscript
More information
Accepted/In Press date: 16 January 2021
e-pub ahead of print date: 21 January 2021
Published date: 1 May 2021
Additional Information:
Funding Information:
Funding : This work was supported by Finnish Foundation for Cardiovascular Research ; Juho Vainio Foundation ; Signe and Ane Gyllenberg Foundation ; Samfundet Folkhälsan ; Finska Läkaresällskapet ; Medicinska Understödsföreningen Liv och Hälsa ; European Commission FP7 (DORIAN) [grant number 278603 ]; EU H2020-PHC-2014-DynaHealth [grant number 633595 ]; and the Academy of Finland [grant number 257239 to MBvB; grant numbers 127437 , 129306 , 130326 , 134791 , 263924 , 274794 to EK; grant numbers 129369 , 129907 , 135072 , 129255 , 126775 to JGE].
Publisher Copyright:
© 2021 Elsevier B.V.
Keywords:
Diabetes mellitus, Epidemiology, Grip strength, Physical fitness, Prediabetes
Identifiers
Local EPrints ID: 446547
URI: http://eprints.soton.ac.uk/id/eprint/446547
ISSN: 0167-4943
PURE UUID: 7694d9dd-e5e4-4c06-8ef0-4a9bd2e5299f
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Date deposited: 15 Feb 2021 17:30
Last modified: 03 Nov 2022 05:01
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Contributors
Author:
Max J. Astrom
Author:
Mikaela B. von Bonsdorff
Author:
Minna K. Salonen
Author:
Eero Kajantie
Author:
Johan G. Eriksson
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