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Escitalopram and paroxetine in the treatment of generalised anxiety disorder: randomised, placebo-controlled, double-blind study

Escitalopram and paroxetine in the treatment of generalised anxiety disorder: randomised, placebo-controlled, double-blind study
Escitalopram and paroxetine in the treatment of generalised anxiety disorder: randomised, placebo-controlled, double-blind study
BACKGROUND: It is uncertain whether higher doses of selective serotonin reuptake inhibitors have greater efficacy in generalised anxiety disorder. AIMS: To assess the efficacy of different doses of escitalopram in generalised anxiety disorder. METHOD: Randomised, double-blind, placebo-controlled, fixed-dose, parallel-group, 12-week study, with 681 patients: placebo (n=139); escitalopram, 5 mg/day, (n=134); 10 mg/day (n=136); 20 mg/day (n=133); paroxetine, 20 mg/day (n=139). RESULTS: Mean change in the primary efficacy measure was greater with escitalopram 10 and 20 mg than with placebo; 10 mg was more efficacious than paroxetine. Paroxetine was superior to placebo on some secondary measures, at some time points. Compared with placebo, more patients withdrew because of adverse events with escitalopram 20 mg and paroxetine. CONCLUSIONS: Escitalopram was efficacious in generalised anxiety disorder, 20 was not significantly superior to 10 mg/day. Escitalopram 10 mg was more efficacious than paroxetine.
0007-1250
264-272
Baldwin, David S.
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Huusom, Anna Karina Trap
6cc632ba-c23c-49ee-a030-dbdbd7240cdf
Mæhlum, Eli
417b1455-60e7-4dfd-9c89-b2e52dce2e15
Baldwin, David S.
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Huusom, Anna Karina Trap
6cc632ba-c23c-49ee-a030-dbdbd7240cdf
Mæhlum, Eli
417b1455-60e7-4dfd-9c89-b2e52dce2e15

Baldwin, David S., Huusom, Anna Karina Trap and Mæhlum, Eli (2006) Escitalopram and paroxetine in the treatment of generalised anxiety disorder: randomised, placebo-controlled, double-blind study. The British Journal of Psychiatry, 189 (3), 264-272. (doi:10.1192/bjp.bp.105.012799).

Record type: Article

Abstract

BACKGROUND: It is uncertain whether higher doses of selective serotonin reuptake inhibitors have greater efficacy in generalised anxiety disorder. AIMS: To assess the efficacy of different doses of escitalopram in generalised anxiety disorder. METHOD: Randomised, double-blind, placebo-controlled, fixed-dose, parallel-group, 12-week study, with 681 patients: placebo (n=139); escitalopram, 5 mg/day, (n=134); 10 mg/day (n=136); 20 mg/day (n=133); paroxetine, 20 mg/day (n=139). RESULTS: Mean change in the primary efficacy measure was greater with escitalopram 10 and 20 mg than with placebo; 10 mg was more efficacious than paroxetine. Paroxetine was superior to placebo on some secondary measures, at some time points. Compared with placebo, more patients withdrew because of adverse events with escitalopram 20 mg and paroxetine. CONCLUSIONS: Escitalopram was efficacious in generalised anxiety disorder, 20 was not significantly superior to 10 mg/day. Escitalopram 10 mg was more efficacious than paroxetine.

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Published date: September 2006

Identifiers

Local EPrints ID: 44668
URI: http://eprints.soton.ac.uk/id/eprint/44668
ISSN: 0007-1250
PURE UUID: 883283f1-c11b-4201-af9d-d457c5c3f928

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Date deposited: 08 Mar 2007
Last modified: 13 Mar 2019 21:06

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Author: Anna Karina Trap Huusom
Author: Eli Mæhlum

University divisions

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