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A PET study exploring the laterality of brainstem activation in migraine using glyceryl trinitrate

A PET study exploring the laterality of brainstem activation in migraine using glyceryl trinitrate
A PET study exploring the laterality of brainstem activation in migraine using glyceryl trinitrate
Migraine is a common disabling condition likely to be associated with dysfunction of brain pathways involved in pain and other sensory modalities. A cardinal, indeed signature, feature of the disorder that led to its name is that the pain may be lateralized. H(2)15O-labelled PET was used to study 24 migraineurs and eight healthy controls. The migraineurs were divided into three groups according to the site of their headache: right, left or bilateral. In each group, a migraine was induced using a glyceryl trinitrate (GTN) infusion. The subjects were scanned at predefined points: pre-infusion, during GTN, during migraine and post-migraine. SPM99 software was used to analyse the data. Significant brainstem activation was seen in the dorsal lateral pons (P < 0.05 after small volume correction) during the migraine state versus the pain-free state when comparing migraineurs with controls. When each group was analysed separately, to investigate laterality, it was found that the dorsal pontine activation was ipsilateral in the right-sided and left-sided groups and bilateral in the bilateral headache group with a left-sided preponderance. Consistent with previous work, the activation persisted after pain was controlled by sumatriptan. These results suggest that lateralization of pain in migraine is due to lateralized brain dysfunction.
migraine, brainstem, PET, glyceryl trinitrate, laterality
0006-8950
932-939
Afridi, S.K.
ad900e1f-0204-4052-8e77-2b31a2f13d12
Matharu, M.S.
02cb2106-d271-4258-9ac5-16a721340108
Lee, L.
5cd660cd-f5d3-4ca2-a44c-4cd70b9a87d4
Kaube, H.
77be5a18-5ca2-4d97-b90c-0ba9bf978f6d
Friston, K.J.
d4a9d75f-46d2-4e52-8359-4b34c8b71aec
Frackowiak, R.S.J.
c340198a-16af-4cc7-b737-d637dcc48d65
Goadsby, P.J.
e490877f-2b31-4806-b5b0-eb369e05233b
Afridi, S.K.
ad900e1f-0204-4052-8e77-2b31a2f13d12
Matharu, M.S.
02cb2106-d271-4258-9ac5-16a721340108
Lee, L.
5cd660cd-f5d3-4ca2-a44c-4cd70b9a87d4
Kaube, H.
77be5a18-5ca2-4d97-b90c-0ba9bf978f6d
Friston, K.J.
d4a9d75f-46d2-4e52-8359-4b34c8b71aec
Frackowiak, R.S.J.
c340198a-16af-4cc7-b737-d637dcc48d65
Goadsby, P.J.
e490877f-2b31-4806-b5b0-eb369e05233b

Afridi, S.K., Matharu, M.S., Lee, L., Kaube, H., Friston, K.J., Frackowiak, R.S.J. and Goadsby, P.J. (2005) A PET study exploring the laterality of brainstem activation in migraine using glyceryl trinitrate. Brain, 128 (4), 932-939. (doi:10.1093/brain/awh416).

Record type: Article

Abstract

Migraine is a common disabling condition likely to be associated with dysfunction of brain pathways involved in pain and other sensory modalities. A cardinal, indeed signature, feature of the disorder that led to its name is that the pain may be lateralized. H(2)15O-labelled PET was used to study 24 migraineurs and eight healthy controls. The migraineurs were divided into three groups according to the site of their headache: right, left or bilateral. In each group, a migraine was induced using a glyceryl trinitrate (GTN) infusion. The subjects were scanned at predefined points: pre-infusion, during GTN, during migraine and post-migraine. SPM99 software was used to analyse the data. Significant brainstem activation was seen in the dorsal lateral pons (P < 0.05 after small volume correction) during the migraine state versus the pain-free state when comparing migraineurs with controls. When each group was analysed separately, to investigate laterality, it was found that the dorsal pontine activation was ipsilateral in the right-sided and left-sided groups and bilateral in the bilateral headache group with a left-sided preponderance. Consistent with previous work, the activation persisted after pain was controlled by sumatriptan. These results suggest that lateralization of pain in migraine is due to lateralized brain dysfunction.

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Published date: 2005
Keywords: migraine, brainstem, PET, glyceryl trinitrate, laterality

Identifiers

Local EPrints ID: 44685
URI: http://eprints.soton.ac.uk/id/eprint/44685
ISSN: 0006-8950
PURE UUID: 9947339f-2b72-42f6-8d03-271535ed6b1f

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Date deposited: 08 Mar 2007
Last modified: 13 Mar 2019 21:06

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Contributors

Author: S.K. Afridi
Author: M.S. Matharu
Author: L. Lee
Author: H. Kaube
Author: K.J. Friston
Author: R.S.J. Frackowiak
Author: P.J. Goadsby

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