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Anti-CD20 monoclonal antibodies in Systemic Lupus Erythematosus

Anti-CD20 monoclonal antibodies in Systemic Lupus Erythematosus
Anti-CD20 monoclonal antibodies in Systemic Lupus Erythematosus
Systemic Lupus Erythematosus (SLE) is an autoimmune inflammatory condition with a wide spectrum of disease manifestations and severities, resulting in significant morbidity and mortality. The aetiopathogenesis of SLE is complex. Young women and certain ethnicities are commonly affected, suggesting a significant hormonal and genetic influence. Diverse immunological abnormalities have been described. A characteristic abnormality is the presence of autoantibodies, implicating a central role for B cells in disease pathogenesis and/or perpetuation. Whilst conventional therapies have improved outcomes, a great unmet need remains. Recently, biological therapies are being explored. B-cell depletion therapy with rituximab has been in use off-label for nearly two decades. Inconsistent results between uncontrolled and controlled studies have raised doubts about its efficacy. In this review, we will focus on B cell abnormalities and the rationale behind B-cell depletion therapy with anti-CD20 monoclonal antibody (mAb), rituximab, will be explored including an evaluation of clinical and trial experience. Finally, we will discuss the mechanistic basis for considering alternative anti-CD20 mAbs.
Anti-CD20 monoclonal antibody, B cell therapy, Biologic, Lupus, Rituximab
1045-1056
1-14
Shah, Kavina
c9e20241-4ba8-4d88-a7f9-1ea62d40044f
Cragg, Mark
ec97f80e-f3c8-49b7-a960-20dff648b78c
Leandro, Maria
47412987-6937-4a86-aac9-42f42b669c1c
Reddy, Venkat
615826e9-84f3-4053-8ce6-26a2eb214bdc
Shah, Kavina
c9e20241-4ba8-4d88-a7f9-1ea62d40044f
Cragg, Mark
ec97f80e-f3c8-49b7-a960-20dff648b78c
Leandro, Maria
47412987-6937-4a86-aac9-42f42b669c1c
Reddy, Venkat
615826e9-84f3-4053-8ce6-26a2eb214bdc

Shah, Kavina, Cragg, Mark, Leandro, Maria and Reddy, Venkat (2021) Anti-CD20 monoclonal antibodies in Systemic Lupus Erythematosus. Biologicals, 69, 1-14. (doi:10.1016/j.biologicals.2020.11.002).

Record type: Article

Abstract

Systemic Lupus Erythematosus (SLE) is an autoimmune inflammatory condition with a wide spectrum of disease manifestations and severities, resulting in significant morbidity and mortality. The aetiopathogenesis of SLE is complex. Young women and certain ethnicities are commonly affected, suggesting a significant hormonal and genetic influence. Diverse immunological abnormalities have been described. A characteristic abnormality is the presence of autoantibodies, implicating a central role for B cells in disease pathogenesis and/or perpetuation. Whilst conventional therapies have improved outcomes, a great unmet need remains. Recently, biological therapies are being explored. B-cell depletion therapy with rituximab has been in use off-label for nearly two decades. Inconsistent results between uncontrolled and controlled studies have raised doubts about its efficacy. In this review, we will focus on B cell abnormalities and the rationale behind B-cell depletion therapy with anti-CD20 monoclonal antibody (mAb), rituximab, will be explored including an evaluation of clinical and trial experience. Finally, we will discuss the mechanistic basis for considering alternative anti-CD20 mAbs.

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Anti-CD20mAbs_4MSC - Accepted Manuscript
Restricted to Repository staff only until 4 December 2021.
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More information

Accepted/In Press date: 8 November 2020
e-pub ahead of print date: 4 December 2020
Published date: January 2021
Keywords: Anti-CD20 monoclonal antibody, B cell therapy, Biologic, Lupus, Rituximab

Identifiers

Local EPrints ID: 446863
URI: http://eprints.soton.ac.uk/id/eprint/446863
ISSN: 1045-1056
PURE UUID: e3743050-851c-43e3-bcd0-7e0ed897e8d3
ORCID for Mark Cragg: ORCID iD orcid.org/0000-0003-2077-089X

Catalogue record

Date deposited: 24 Feb 2021 17:32
Last modified: 22 Nov 2021 02:42

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Contributors

Author: Kavina Shah
Author: Mark Cragg ORCID iD
Author: Maria Leandro
Author: Venkat Reddy

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