READ ME File For Datadet for 'Conformational fingerprinting of tau variants and strains by Raman spectroscopy'

Dataset DOI:  

ReadMe Author: George Devitt, University of Southampton

This dataset supports the publication:

AUTHORS: George Devitt (Creator), Anna Crisford (Contributor), William Rice (Contributor), Hilary A. Weismiller (Contributor), Zhanyun Fan (Contributor), Caitlin Commins (Contributor), Bradley T. Hyman (Contributor), Martin Margittai (Contributor), Sumeet Mahajan (Contributor) and Amrit Mudher (Contributor)
TITLE: Conformational fingerprinting of tau variants and strains by Raman spectroscopy 
JOURNAL:RSC Advances 
PAPER DOI: 10.1039/D1RA00870F 


This dataset contains: Datasets for Fig. 2, 3, 4 and Supplementary Fig. 1 


Data includes all raw Raman spectra used in the manuscript, including background spectra. Data is in .txt format and can be opened in Microscoft Excel to display in Irootlab format (Matlab plugin: https://trevisanj.github.io/irootlab/)


The figures are as follows:

Fig. 2  [Raman spectra of tau fibril strains formed in the presence of heparin in PBS or Tris buffer]
Fig. 3   [Raman spectra of RNA and heparin, as well as tau fibril strains formed in the presence of heparin* or RNA in PBS buffer]
Fig. 4   [Raman spectra of tau fibril variants 2N4R, 0N3R, K18 and P301S formed in the presence of heparin in Hepes buffer]
Fig. S1a [Raman spectra of B2M fibril strains formed in citrate buffer with high or low NaCl salt]

*Raw data for tau fibrils formed in the presence of heparin in PBS buffer found in Fig2_TauStrains_raw_data.txt document only.

Date of data collection: 28/03/2019 - 11/05/2020

Information about geographic location of data collection: University of Southampton, U.K.

License CC BY

Readme file created: 04/03/2021
Version updated: