Risk of contamination of lidocaine hydrochloride and phenylephrine hydrochloride topical solution: in vivo and in vitro analyses
Risk of contamination of lidocaine hydrochloride and phenylephrine hydrochloride topical solution: in vivo and in vitro analyses
Objective:
To investigate the risk of contamination of lidocaine hydrochloride 5 per cent weight/volume and phenylephrine hydrochloride 0.5 per cent weight/volume topical solution, both in patients (in vivo) and in the laboratory setting (in vitro).
Methods:
This paper reports a prospective study involving 10 samples of the lidocaine hydrochloride and phenylephrine hydrochloride topical anaesthetic spray. The samples were assessed for microbiological contamination after a single use on patients in a controlled laboratory environment. Additional samples were assessed for baseline contamination and later assessed for contamination in an in vitro setting.
Results:
In the in vivo setting, 2 of the 10 samples were positive for cultures from both the pump and the bottles. However, in the in vitro setting, the pump and the contents of the bottles were contaminated after a single use when the sterile solution was sprayed from distances of 1 and 2 cm.
Conclusion:
The lidocaine hydrochloride and phenylephrine hydrochloride topical solution assembly was contaminated in both in vivo and in vitro settings after a single use.
Anesthetics, Cross Infection, Drug Contamination, Endoscopy, Lidocaine, Local, Phenylephrine
799-801
Jog, M.
5fb02c60-92fc-4504-9657-ef391bfb85aa
Sachidananda, R.
5a38ab74-5b6b-4e25-b71c-46392e4292d2
Saeed, K.
87cb67e5-71e8-4759-bf23-2ea00ebd8b39
August 2013
Jog, M.
5fb02c60-92fc-4504-9657-ef391bfb85aa
Sachidananda, R.
5a38ab74-5b6b-4e25-b71c-46392e4292d2
Saeed, K.
87cb67e5-71e8-4759-bf23-2ea00ebd8b39
Jog, M., Sachidananda, R. and Saeed, K.
(2013)
Risk of contamination of lidocaine hydrochloride and phenylephrine hydrochloride topical solution: in vivo and in vitro analyses.
Journal of Laryngology and Otology, 127 (8), .
(doi:10.1017/S0022215113001564).
Abstract
Objective:
To investigate the risk of contamination of lidocaine hydrochloride 5 per cent weight/volume and phenylephrine hydrochloride 0.5 per cent weight/volume topical solution, both in patients (in vivo) and in the laboratory setting (in vitro).
Methods:
This paper reports a prospective study involving 10 samples of the lidocaine hydrochloride and phenylephrine hydrochloride topical anaesthetic spray. The samples were assessed for microbiological contamination after a single use on patients in a controlled laboratory environment. Additional samples were assessed for baseline contamination and later assessed for contamination in an in vitro setting.
Results:
In the in vivo setting, 2 of the 10 samples were positive for cultures from both the pump and the bottles. However, in the in vitro setting, the pump and the contents of the bottles were contaminated after a single use when the sterile solution was sprayed from distances of 1 and 2 cm.
Conclusion:
The lidocaine hydrochloride and phenylephrine hydrochloride topical solution assembly was contaminated in both in vivo and in vitro settings after a single use.
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More information
e-pub ahead of print date: 30 July 2013
Published date: August 2013
Additional Information:
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
Keywords:
Anesthetics, Cross Infection, Drug Contamination, Endoscopy, Lidocaine, Local, Phenylephrine
Identifiers
Local EPrints ID: 447289
URI: http://eprints.soton.ac.uk/id/eprint/447289
ISSN: 0022-2151
PURE UUID: 73265f6d-79b3-40ec-a3d2-79ca40140d38
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Date deposited: 08 Mar 2021 17:33
Last modified: 17 Mar 2024 03:56
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Contributors
Author:
M. Jog
Author:
R. Sachidananda
Author:
K. Saeed
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