The University of Southampton
University of Southampton Institutional Repository

A multi-centre clinical evaluation of reactive oxygen topical wound gel in 114 wounds

A multi-centre clinical evaluation of reactive oxygen topical wound gel in 114 wounds
A multi-centre clinical evaluation of reactive oxygen topical wound gel in 114 wounds

Objective: This article reports the outcomes of the use of Surgihoney RO (SHRO), topical wound dressing in a multi-centre, international setting. The aims were to explore the clinical effects of SHRO, including a reduction in bacterial load and biofilm and improvement in healing in a variety of challenging non-healing and clinically infected wounds. 

Method: This was a non-comparative evaluation, where both acute and chronic wounds with established delayed healing were treated with the dressing. Clinicians prospectively recorded wound improvement or deterioration, level of wound exudate, presence of pain, and presence of slough and necrosis. Analysis of this data provided information on clinical performance of the dressing. Semi-quantitative culture to assess bacterial bioburden was performed where possible. 

Results: We recruited 104 patients, mean age 61 years old, with 114 wounds. The mean duration of wounds before treatment was 3.7 months and the mean duration of treatment was 25.7 days. During treatment 24 wounds (21%) healed and the remaining 90 (79%) wounds improved following application of the dressing. No deterioration in any wound was observed. A reduction in patient pain, level of wound exudate and in devitalised tissue were consistently reported. These positive improvements in wound progress were reflected in the wound cultures that showed a reduction in bacterial load in 39 out of the 40 swabs taken. There were two adverse events recorded: a stinging sensation following application of the dressing was experienced by 2 patients, and 2 elderly patients died of causes unrelated to the dressing or to the chronic wound. These patients' wounds and their response to SHRO have been included in the analysis. 

Conclusion: SHRO was well tolerated and shows great promise as an effective potent topical antimicrobial in the healing of challenging wounds. •Declaration of interest: Matthew Dryden has become a shareholder in Matoke Holdings, the manufacturer of Surgihoney RO, since the completion of this study. Keith Cutting is a consultant to Matoke Holdings.

Acute wound, Chronic wound, Clinical evaluation, RO surgihoney, Topical antimicrobial gel
0969-0700
140-146
Dryden, M.
a6c300f9-5c26-4884-980b-c098b0688ab1
Dickinson, A.
626ef76a-f4d0-4287-a830-d92851574b3b
Brooks, J.
7a2bf0e7-7ddf-42d2-be3b-23aabd37cfe8
Hudgell, L.
f604e333-5f58-4a26-83da-5b9a14d2f5b8
Saeed, K.
87cb67e5-71e8-4759-bf23-2ea00ebd8b39
Cutting, K.F.
0daf4225-6eca-4037-8b33-39aa1ad86dc3
Dryden, M.
a6c300f9-5c26-4884-980b-c098b0688ab1
Dickinson, A.
626ef76a-f4d0-4287-a830-d92851574b3b
Brooks, J.
7a2bf0e7-7ddf-42d2-be3b-23aabd37cfe8
Hudgell, L.
f604e333-5f58-4a26-83da-5b9a14d2f5b8
Saeed, K.
87cb67e5-71e8-4759-bf23-2ea00ebd8b39
Cutting, K.F.
0daf4225-6eca-4037-8b33-39aa1ad86dc3

Dryden, M., Dickinson, A., Brooks, J., Hudgell, L., Saeed, K. and Cutting, K.F. (2016) A multi-centre clinical evaluation of reactive oxygen topical wound gel in 114 wounds. Journal of Wound Care, 25 (3), 140-146. (doi:10.12968/jowc.2016.25.3.140).

Record type: Article

Abstract

Objective: This article reports the outcomes of the use of Surgihoney RO (SHRO), topical wound dressing in a multi-centre, international setting. The aims were to explore the clinical effects of SHRO, including a reduction in bacterial load and biofilm and improvement in healing in a variety of challenging non-healing and clinically infected wounds. 

Method: This was a non-comparative evaluation, where both acute and chronic wounds with established delayed healing were treated with the dressing. Clinicians prospectively recorded wound improvement or deterioration, level of wound exudate, presence of pain, and presence of slough and necrosis. Analysis of this data provided information on clinical performance of the dressing. Semi-quantitative culture to assess bacterial bioburden was performed where possible. 

Results: We recruited 104 patients, mean age 61 years old, with 114 wounds. The mean duration of wounds before treatment was 3.7 months and the mean duration of treatment was 25.7 days. During treatment 24 wounds (21%) healed and the remaining 90 (79%) wounds improved following application of the dressing. No deterioration in any wound was observed. A reduction in patient pain, level of wound exudate and in devitalised tissue were consistently reported. These positive improvements in wound progress were reflected in the wound cultures that showed a reduction in bacterial load in 39 out of the 40 swabs taken. There were two adverse events recorded: a stinging sensation following application of the dressing was experienced by 2 patients, and 2 elderly patients died of causes unrelated to the dressing or to the chronic wound. These patients' wounds and their response to SHRO have been included in the analysis. 

Conclusion: SHRO was well tolerated and shows great promise as an effective potent topical antimicrobial in the healing of challenging wounds. •Declaration of interest: Matthew Dryden has become a shareholder in Matoke Holdings, the manufacturer of Surgihoney RO, since the completion of this study. Keith Cutting is a consultant to Matoke Holdings.

This record has no associated files available for download.

More information

Published date: 2 March 2016
Additional Information: Copyright: Copyright 2016 Elsevier B.V., All rights reserved.
Keywords: Acute wound, Chronic wound, Clinical evaluation, RO surgihoney, Topical antimicrobial gel

Identifiers

Local EPrints ID: 447327
URI: http://eprints.soton.ac.uk/id/eprint/447327
ISSN: 0969-0700
PURE UUID: 4bfeab1b-fe71-49f5-9c9c-524438a36bb2
ORCID for K. Saeed: ORCID iD orcid.org/0000-0003-0123-0302

Catalogue record

Date deposited: 09 Mar 2021 17:32
Last modified: 11 Mar 2022 03:00

Export record

Altmetrics

Contributors

Author: M. Dryden
Author: A. Dickinson
Author: J. Brooks
Author: L. Hudgell
Author: K. Saeed ORCID iD
Author: K.F. Cutting

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×