Research Evaluation Alongside Clinical Treatment in COVID-19 (REACT COVID-19): an observational and biobanking study

Accepted/In Press date: 2 January 2021

Published date: 22 January 2021

Additional Information: Funding Information: 1Faculty of Medicine, University of Southampton, Southampton, UK 2University Hospital Southampton NHS Foundation Trust, Southampton, UK 3Institute for Life Sciences, University of Southampton, Southampton, UK 4Clinical Informatics Research Unit, Faculty of Medicine, University of Southampton, Southampton, UK 5NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK 6Cancer Sciences Unit, Faculty of Medicine, University of Southampton, UK 7NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, UK 8University of Manchester, Cancer Biomarker Centre, Cancer Research UK Manchester Institute, Manchester, UK Acknowledgements The authors acknowledge the National Institute for Health Research (NIHR) Southampton Clinical Research Facility (CRF) and University Hospital Southampton NHS Foundation Trust Research Nursing teams for their support in the set-up of this study, Dr Dave Stockley (National Institute for Health Research CRF Southampton Research Biorepository Manager) and Dr Alastair Watson for their help in proofreading and preparation of the manuscript for submission. Contributors HB and AF designed the protocol and drafted the manuscript; AD and MC were involved in protocol design; JB, HP and FB were involved in the realisation of data extraction, integration, transformation and upload processes; CK, GT and SNF were involved in protocol design for the biobanking subcohort; NS and SW are involved in manual data collection processes; DL, PF, HP and JB were involved in the design and adaptation of the Real-time Analytics for Clinical Trials platform; and TW was involved in study conception and protocol design. All authors reviewed the final manuscript. Funding The REACT platform has been supported by the digital Experimental Cancer Medicine Team free of charge. The biobanking subcohort is supported the NIHR Southampton CRF and NIHR Southampton Biomedical Research Centre at University Hospital Southampton NHS Foundation Trust and as part of a broader effort (Enabling New Treatment Approaches for COVID-19 Treatment) by the University of Southampton (UoS) charity (Office of Development and Alumni Relations). In addition the Clinical Informatics Research Unit, UoS has supported infrastructure costs. The support described above was not provided from a specific award or grant. Funding Information: The REACT COVID-19 study is mindful of the national and international efforts to bring together data from multiple centres in order to enhance the power of studies, be they clinical, observation, mechanistic or intervention studies. The study will therefore be aligning itself with the broader UHS and UoS research project of Enabling new treatment approaches for COVID-19 Treatment, supported by the Southampton Coronavirus Support Fund, NIHR Southampton BRC and NIHR Southampton CRF. Funding Information: The Research Evaluation Alongside Clinical Treatment observational and biobanking study of COVID-19 (REACT COVID-19 study) evolved around a collaboration between the University of Southampton (UoS), University Hospital Southampton NHS Foundation Trust (UHSFT) and the digital Experimental Cancer Medicine Team (ECMT) and their work to create the REACT platform. The REACT platform is used for the determination of early clinical benefit of new cancer medicines in early-phase drug trials and has been adapted by the digital ECMT in collaboration with UHSFT to allow rapid upload and interpretation of clinical data in the context of the COVID-19 pandemic. This study is supported by the National Institute for Health Research (NIHR) Southampton Clinical Research Facility (CRF) and NIHR Southampton Biomedical Research Centre (BRC), which takes advantage of the expertise and resource in hosting large prospective cohort studies. Publisher Copyright: ©

Keywords: chronic airways disease, COVID-19, health informatics, protocols & guidelines, respiratory infections, respiratory medicine (see thoracic medicine)

Local EPrints ID: 447403

URI: http://eprints.soton.ac.uk/id/eprint/447403

DOI: doi:10.1136/bmjopen-2020-043012

ISSN: 2044-6055

PURE UUID: 5ebba226-6d2f-40d8-bcc1-74c1342a4d3a

ORCID for Hannah Burke: orcid.org/0000-0003-3553-4590

ORCID for Ahilanandan Dushianthan: orcid.org/0000-0002-0165-3359

ORCID for James Batchelor: orcid.org/0000-0002-5307-552X

ORCID for Christopher Kipps: orcid.org/0000-0002-5205-9712

ORCID for Saul N. Faust: orcid.org/0000-0003-3410-7642

Date deposited: 10 Mar 2021 17:43

Last modified: 22 Apr 2024 01:52