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Cryptic resistance in Staphylococcus aureus: A risk for the treatment of skin infection?

Cryptic resistance in Staphylococcus aureus: A risk for the treatment of skin infection?
Cryptic resistance in Staphylococcus aureus: A risk for the treatment of skin infection?

PURPOSE OF REVIEW: The purpose of this review is to explore major challenges that face routine diagnostic laboratories in detecting cryptic (hidden) antibiotic resistances in Staphylococcus aureus and the impact of these covert resistances in the management of skin and soft tissue infections. 

RECENT FINDINGS: The review covers recent literature and works regarding a number of evolving mechanisms and forms of antibiotic resistances in S. aureus, including novel oxacillin-susceptible-mecA-positive meticillin-resistant S. aureus (OS-MRSA) strains and MRSA isolates that harbour a divergent mecA homologue termed mecC within the novel staphylococcal cassette chromosome mec XI element. 

SUMMARY: S. aureus strains causing skin and soft tissue infections are evolving with regard to virulence as well as antimicrobial resistance. Cryptic resistances continue to escape routine diagnostic tests. This means that there are still many unknowns regarding their global dissemination, virulence, threats in clinical practice and optimal treatment strategies. Larger studies are needed to further understand the pathogenic consequences of cryptic resistances in S. aureus in skin and soft tissue infections, which may ultimately provide novel preventive or treatment approaches for this significant human pathogen.

cryptic resistance, heteroresistant vancomycin-intermediate S. aureus, MecC, oxacillin-susceptible meticillin-resistant S. aureus, small colony variants
0951-7375
130-136
Saeed, Kordo
87cb67e5-71e8-4759-bf23-2ea00ebd8b39
Marsh, Peter
18f63c35-264b-4ec9-8505-9c57bf707ad2
Ahmad, Nusreen
8638eaf5-db5a-4327-826f-679fcc237b65
Saeed, Kordo
87cb67e5-71e8-4759-bf23-2ea00ebd8b39
Marsh, Peter
18f63c35-264b-4ec9-8505-9c57bf707ad2
Ahmad, Nusreen
8638eaf5-db5a-4327-826f-679fcc237b65

Saeed, Kordo, Marsh, Peter and Ahmad, Nusreen (2014) Cryptic resistance in Staphylococcus aureus: A risk for the treatment of skin infection? Current Opinion in Infectious Diseases, 27 (2), 130-136. (doi:10.1097/QCO.0000000000000046).

Record type: Review

Abstract

PURPOSE OF REVIEW: The purpose of this review is to explore major challenges that face routine diagnostic laboratories in detecting cryptic (hidden) antibiotic resistances in Staphylococcus aureus and the impact of these covert resistances in the management of skin and soft tissue infections. 

RECENT FINDINGS: The review covers recent literature and works regarding a number of evolving mechanisms and forms of antibiotic resistances in S. aureus, including novel oxacillin-susceptible-mecA-positive meticillin-resistant S. aureus (OS-MRSA) strains and MRSA isolates that harbour a divergent mecA homologue termed mecC within the novel staphylococcal cassette chromosome mec XI element. 

SUMMARY: S. aureus strains causing skin and soft tissue infections are evolving with regard to virulence as well as antimicrobial resistance. Cryptic resistances continue to escape routine diagnostic tests. This means that there are still many unknowns regarding their global dissemination, virulence, threats in clinical practice and optimal treatment strategies. Larger studies are needed to further understand the pathogenic consequences of cryptic resistances in S. aureus in skin and soft tissue infections, which may ultimately provide novel preventive or treatment approaches for this significant human pathogen.

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More information

Published date: April 2014
Additional Information: Copyright: Copyright 2014 Elsevier B.V., All rights reserved.
Keywords: cryptic resistance, heteroresistant vancomycin-intermediate S. aureus, MecC, oxacillin-susceptible meticillin-resistant S. aureus, small colony variants

Identifiers

Local EPrints ID: 447415
URI: http://eprints.soton.ac.uk/id/eprint/447415
ISSN: 0951-7375
PURE UUID: 19939544-cdb1-4804-b266-2bf9d9533e7d
ORCID for Kordo Saeed: ORCID iD orcid.org/0000-0003-0123-0302

Catalogue record

Date deposited: 11 Mar 2021 17:30
Last modified: 23 Jul 2022 02:24

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Contributors

Author: Kordo Saeed ORCID iD
Author: Peter Marsh
Author: Nusreen Ahmad

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