The University of Southampton
University of Southampton Institutional Repository

The value of procalcitonin measurement in localized skin and skin structure infection, diabetic foot infections, septic arthritis and osteomyelitis

The value of procalcitonin measurement in localized skin and skin structure infection, diabetic foot infections, septic arthritis and osteomyelitis
The value of procalcitonin measurement in localized skin and skin structure infection, diabetic foot infections, septic arthritis and osteomyelitis

Serum procalcitonin (PCT) is an established diagnostic marker for severe or systemic bacterial infections such as pneumonia, sepsis and septic shock. Data regarding the role of PCT in localized infections without systemic inflammatory response syndrome are scarce. The aim of this review is to assess the value of PCT measurements in localized infections such as skin and skin structure infections, diabetic foot infections, septic arthritis (SA) and osteomyelitis. It appears that serum PCT is unlikely to change the clinical practice in skin and skin structure infection. However, serum PCT could have a role in diagnosis and monitoring of diabetic foot infections in hospitalized settings. There are conflicting reports regarding the ability of serum PCT to distinguish SA from non-SA; synovial PCT may be more appropriate in these settings, including in implant-related infections. Better designed studies are needed to evaluate the usefulness of PCT with or without other biomarkers in localized infections.

Arthritis, Diabetic foot infections, Localised infections, Procalcitonin, Septic
1473-7159
47-54
Saeed, Kordo
87cb67e5-71e8-4759-bf23-2ea00ebd8b39
Ahmad, Nusreen
8638eaf5-db5a-4327-826f-679fcc237b65
Dryden, Matthew
a6c300f9-5c26-4884-980b-c098b0688ab1
Saeed, Kordo
87cb67e5-71e8-4759-bf23-2ea00ebd8b39
Ahmad, Nusreen
8638eaf5-db5a-4327-826f-679fcc237b65
Dryden, Matthew
a6c300f9-5c26-4884-980b-c098b0688ab1

Saeed, Kordo, Ahmad, Nusreen and Dryden, Matthew (2014) The value of procalcitonin measurement in localized skin and skin structure infection, diabetic foot infections, septic arthritis and osteomyelitis. Expert Review of Molecular Diagnostics, 14 (1), 47-54. (doi:10.1586/14737159.2014.864238).

Record type: Review

Abstract

Serum procalcitonin (PCT) is an established diagnostic marker for severe or systemic bacterial infections such as pneumonia, sepsis and septic shock. Data regarding the role of PCT in localized infections without systemic inflammatory response syndrome are scarce. The aim of this review is to assess the value of PCT measurements in localized infections such as skin and skin structure infections, diabetic foot infections, septic arthritis (SA) and osteomyelitis. It appears that serum PCT is unlikely to change the clinical practice in skin and skin structure infection. However, serum PCT could have a role in diagnosis and monitoring of diabetic foot infections in hospitalized settings. There are conflicting reports regarding the ability of serum PCT to distinguish SA from non-SA; synovial PCT may be more appropriate in these settings, including in implant-related infections. Better designed studies are needed to evaluate the usefulness of PCT with or without other biomarkers in localized infections.

This record has no associated files available for download.

More information

Published date: January 2014
Additional Information: Copyright: Copyright 2014 Elsevier B.V., All rights reserved.
Keywords: Arthritis, Diabetic foot infections, Localised infections, Procalcitonin, Septic

Identifiers

Local EPrints ID: 447512
URI: http://eprints.soton.ac.uk/id/eprint/447512
ISSN: 1473-7159
PURE UUID: b1c6339a-6fb1-4cd9-a8cb-d8aba68ebb50
ORCID for Kordo Saeed: ORCID iD orcid.org/0000-0003-0123-0302

Catalogue record

Date deposited: 12 Mar 2021 17:36
Last modified: 23 Jul 2022 02:24

Export record

Altmetrics

Contributors

Author: Kordo Saeed ORCID iD
Author: Nusreen Ahmad
Author: Matthew Dryden

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×