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Computational stem cell biology: Open questions and guiding principles

Computational stem cell biology: Open questions and guiding principles
Computational stem cell biology: Open questions and guiding principles

Computational biology is enabling an explosive growth in our understanding of stem cells and our ability to use them for disease modeling, regenerative medicine, and drug discovery. We discuss four topics that exemplify applications of computation to stem cell biology: cell typing, lineage tracing, trajectory inference, and regulatory networks. We use these examples to articulate principles that have guided computational biology broadly and call for renewed attention to these principles as computation becomes increasingly important in stem cell biology. We also discuss important challenges for this field with the hope that it will inspire more to join this exciting area.

1934-5909
20-32
Cahan, Patrick
4385d63e-8130-4bca-aec2-1f755823087e
Cacchiarelli, Davide
7d8d037c-d90a-465b-bac3-ccc41e089101
Dunn, Sara-Jane
95829b9e-ef85-4b1a-baba-b2dcc88c40f7
Hemberg, Martin
55166842-3a86-4fa4-899c-bee71b917906
de Sousa Lopes, Susana M Chuva
8f1c7d34-1e96-4ef6-ad07-8ab2816451f1
Morris, Samantha A
85815eb1-df4b-4b2d-9069-60ff87b6e856
Rackham, Owen J L
8122eb1f-6e9f-4da5-90e1-ce108ccbbcbf
Del Sol, Antonio
d4b523a9-0b8c-40eb-89b9-a903b80b1c99
Wells, Christine A
a132ead6-3d14-4296-a60e-851642b192c8
Cahan, Patrick
4385d63e-8130-4bca-aec2-1f755823087e
Cacchiarelli, Davide
7d8d037c-d90a-465b-bac3-ccc41e089101
Dunn, Sara-Jane
95829b9e-ef85-4b1a-baba-b2dcc88c40f7
Hemberg, Martin
55166842-3a86-4fa4-899c-bee71b917906
de Sousa Lopes, Susana M Chuva
8f1c7d34-1e96-4ef6-ad07-8ab2816451f1
Morris, Samantha A
85815eb1-df4b-4b2d-9069-60ff87b6e856
Rackham, Owen J L
8122eb1f-6e9f-4da5-90e1-ce108ccbbcbf
Del Sol, Antonio
d4b523a9-0b8c-40eb-89b9-a903b80b1c99
Wells, Christine A
a132ead6-3d14-4296-a60e-851642b192c8

Cahan, Patrick, Cacchiarelli, Davide, Dunn, Sara-Jane, Hemberg, Martin, de Sousa Lopes, Susana M Chuva, Morris, Samantha A, Rackham, Owen J L, Del Sol, Antonio and Wells, Christine A (2021) Computational stem cell biology: Open questions and guiding principles. Cell Stem Cell, 28 (1), 20-32. (doi:10.1016/j.stem.2020.12.012).

Record type: Letter

Abstract

Computational biology is enabling an explosive growth in our understanding of stem cells and our ability to use them for disease modeling, regenerative medicine, and drug discovery. We discuss four topics that exemplify applications of computation to stem cell biology: cell typing, lineage tracing, trajectory inference, and regulatory networks. We use these examples to articulate principles that have guided computational biology broadly and call for renewed attention to these principles as computation becomes increasingly important in stem cell biology. We also discuss important challenges for this field with the hope that it will inspire more to join this exciting area.

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More information

Published date: 7 January 2021
Additional Information: Copyright © 2020 Elsevier Inc. All rights reserved.

Identifiers

Local EPrints ID: 447562
URI: http://eprints.soton.ac.uk/id/eprint/447562
ISSN: 1934-5909
PURE UUID: 509ba981-c364-48b3-ad7a-cc13eb3a8798
ORCID for Owen J L Rackham: ORCID iD orcid.org/0000-0002-4390-0872

Catalogue record

Date deposited: 16 Mar 2021 17:32
Last modified: 17 Mar 2024 04:03

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Contributors

Author: Patrick Cahan
Author: Davide Cacchiarelli
Author: Sara-Jane Dunn
Author: Martin Hemberg
Author: Susana M Chuva de Sousa Lopes
Author: Samantha A Morris
Author: Antonio Del Sol
Author: Christine A Wells

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