The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Total body water in full term and preterm newborns: systematic review and meta-analysis

Total body water in full term and preterm newborns: systematic review and meta-analysis
Total body water in full term and preterm newborns: systematic review and meta-analysis
Background Total body water (TBW) is one component of fat-free mass and changes in TBW are influenced by fluid shifts (especially during transition to postnatal life), electrolyte balance and nutritional status. Normal values for term-born neonates and preterm infants at birth have not been defined in large cohorts, limiting investigation into its monitoring and use in clinical practice.

Objective To systematically review the evidence base for percentage of TBW in term-born infants, quantify the effect of prematurity on TBW at birth, and describe normal progression of TBW over time in preterm infants.

Methods Systematic review of Medline, Web of Science Core Collection and EBSCO-CINAHL (January 1946 to January 2020). Included articles used dilutional methods to assess TBW.

Results Searches identified 2349 articles of which 22 included data suitable for analysis. Mean TBW in term-born newborns was 73.8% (95% CI 72.47% to 75.06%, 15 studies, 433 infants). Meta-regression showed that TBW was higher in preterm infants (up to 90% at 26 weeks gestation, dropping to 75% at 36 weeks corrected gestation) and was negatively correlated with gestation at birth, falling 1.44% per week (95% CI 0.63% to 2.24%, 9 studies, 179 infants). Analysis of TBW over time during the ex utero growth of preterm infants was not possible due to paucity of data.

Conclusion This review defines the normal TBW percentage in term-born infants and confirms and quantifies previous findings that preterm infants have a higher TBW percentage.
growth, neonatology
1359-2998
542-548
Young, Aneurin
cf3d7c90-4f55-4467-a59c-a84b5e5915ed
Brown, Lisa K
03ad5912-0e84-4f46-87c2-f245113b2bcb
Ennis, Sarah
7b57f188-9d91-4beb-b217-09856146f1e9
Johnson, Mark
ce07b5dd-b12b-47df-a5df-cd3b9447c9ed
Beattie, R.M.
977a2f68-2bcf-4436-87e7-28a39952adda
Young, Aneurin
cf3d7c90-4f55-4467-a59c-a84b5e5915ed
Brown, Lisa K
03ad5912-0e84-4f46-87c2-f245113b2bcb
Ennis, Sarah
7b57f188-9d91-4beb-b217-09856146f1e9
Johnson, Mark
ce07b5dd-b12b-47df-a5df-cd3b9447c9ed
Beattie, R.M.
977a2f68-2bcf-4436-87e7-28a39952adda

Young, Aneurin, Brown, Lisa K, Ennis, Sarah, Johnson, Mark and Beattie, R.M. (2021) Total body water in full term and preterm newborns: systematic review and meta-analysis. Archives of Disease in Childhood - Fetal and Neonatal Edition, 106 (5), 542-548. (doi:10.1136/archdischild-2020-321112).

Record type: Article

Abstract

Background Total body water (TBW) is one component of fat-free mass and changes in TBW are influenced by fluid shifts (especially during transition to postnatal life), electrolyte balance and nutritional status. Normal values for term-born neonates and preterm infants at birth have not been defined in large cohorts, limiting investigation into its monitoring and use in clinical practice.

Objective To systematically review the evidence base for percentage of TBW in term-born infants, quantify the effect of prematurity on TBW at birth, and describe normal progression of TBW over time in preterm infants.

Methods Systematic review of Medline, Web of Science Core Collection and EBSCO-CINAHL (January 1946 to January 2020). Included articles used dilutional methods to assess TBW.

Results Searches identified 2349 articles of which 22 included data suitable for analysis. Mean TBW in term-born newborns was 73.8% (95% CI 72.47% to 75.06%, 15 studies, 433 infants). Meta-regression showed that TBW was higher in preterm infants (up to 90% at 26 weeks gestation, dropping to 75% at 36 weeks corrected gestation) and was negatively correlated with gestation at birth, falling 1.44% per week (95% CI 0.63% to 2.24%, 9 studies, 179 infants). Analysis of TBW over time during the ex utero growth of preterm infants was not possible due to paucity of data.

Conclusion This review defines the normal TBW percentage in term-born infants and confirms and quantifies previous findings that preterm infants have a higher TBW percentage.

Text
Young_FNN_MAR21 - Accepted Manuscript
Download (382kB)

More information

Accepted/In Press date: 12 March 2021
e-pub ahead of print date: 31 March 2021
Published date: 19 August 2021
Keywords: growth, neonatology

Identifiers

Local EPrints ID: 447723
URI: http://eprints.soton.ac.uk/id/eprint/447723
ISSN: 1359-2998
PURE UUID: 70dc6d87-5598-44d1-be88-af5366b965ca
ORCID for Aneurin Young: ORCID iD orcid.org/0000-0003-3549-3813
ORCID for Sarah Ennis: ORCID iD orcid.org/0000-0003-2648-0869
ORCID for Mark Johnson: ORCID iD orcid.org/0000-0003-1829-9912

Catalogue record

Date deposited: 18 Mar 2021 17:59
Last modified: 22 Nov 2021 08:18

Export record

Altmetrics

Contributors

Author: Aneurin Young ORCID iD
Author: Lisa K Brown
Author: Sarah Ennis ORCID iD
Author: Mark Johnson ORCID iD
Author: R.M. Beattie

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×