Telomerase: a key player in the pathogenesis of non-alcoholic fatty liver disease?
Telomerase: a key player in the pathogenesis of non-alcoholic fatty liver disease?
Introduction: telomerase is a basic nuclear protein reverse transcriptase, which plays a key role in maintaining telomere stability, genome integrity, long-term cell activity, and potential continued proliferation.
Area covered: this narrative review discusses key research advances involving telomerase in the development and progression of nonalcoholic fatty liver disease (NAFLD). The review evaluates 9a) whether the assessment of telomerase can be used as a noninvasive diagnostic tool; and (b) whether modification of telomerase function might be a useful potential therapeutic target for treatment of NAFLD. Furthermore, the relationship between telomerase and other chronic metabolic diseases is evaluated.
Expert opinion: several experimental and preclinical studies have suggested that telomerase plays an important role in the development of NAFLD. However, further mechanistic studies are needed to prove a causal relationship and to better elucidate whether the measurement of telomerase has utility as a diagnostic tool or whether pharmacological manipulation of telomerase has therapeutic potential in NAFLD treatment.
Telomerase, hepatocellular carcinoma, lipid metabolism, liver fibrosis, metabolic disorders, nonalcoholic fatty liver disease, therapeutic targets
811-819
Tang, Liang-Jie
2264df6a-7a5b-4975-aa3a-f71461ff02e1
Rios, Rafael S.
81e78e78-b435-4d81-9818-450c0b0fbbb6
Zhang, Huai
48825a14-d2c5-4e99-a408-e637593eeefd
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
Targher, Giovanni
043e0811-b389-4922-974e-22e650212c5f
Zheng, Ming-Hua
739bce60-8382-432f-b679-a3371ea83b7c
3 July 2021
Tang, Liang-Jie
2264df6a-7a5b-4975-aa3a-f71461ff02e1
Rios, Rafael S.
81e78e78-b435-4d81-9818-450c0b0fbbb6
Zhang, Huai
48825a14-d2c5-4e99-a408-e637593eeefd
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
Targher, Giovanni
043e0811-b389-4922-974e-22e650212c5f
Zheng, Ming-Hua
739bce60-8382-432f-b679-a3371ea83b7c
Tang, Liang-Jie, Rios, Rafael S., Zhang, Huai, Byrne, Christopher, Targher, Giovanni and Zheng, Ming-Hua
(2021)
Telomerase: a key player in the pathogenesis of non-alcoholic fatty liver disease?
Expert Review of Gastroenterology & Hepatology, 15 (7), .
(doi:10.1080/17474124.2021.1903318).
Abstract
Introduction: telomerase is a basic nuclear protein reverse transcriptase, which plays a key role in maintaining telomere stability, genome integrity, long-term cell activity, and potential continued proliferation.
Area covered: this narrative review discusses key research advances involving telomerase in the development and progression of nonalcoholic fatty liver disease (NAFLD). The review evaluates 9a) whether the assessment of telomerase can be used as a noninvasive diagnostic tool; and (b) whether modification of telomerase function might be a useful potential therapeutic target for treatment of NAFLD. Furthermore, the relationship between telomerase and other chronic metabolic diseases is evaluated.
Expert opinion: several experimental and preclinical studies have suggested that telomerase plays an important role in the development of NAFLD. However, further mechanistic studies are needed to prove a causal relationship and to better elucidate whether the measurement of telomerase has utility as a diagnostic tool or whether pharmacological manipulation of telomerase has therapeutic potential in NAFLD treatment.
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Accepted/In Press date: 10 March 2021
e-pub ahead of print date: 19 March 2021
Published date: 3 July 2021
Additional Information:
Funding Information:
This paper was funded by grants from the National Natural Science Foundation of China (82070588), High Level Creative Talents from Department of Public Health in Zhejiang Province (S2032102600032) and Project of New Century 551 Talent Nurturing in Wenzhou. G Targher is supported in part by grants from the School of Medicine, University of Verona, Verona, Italy. C D Byrne is supported in part by the Southampton NIHR Biomedical Research Centre(IS-BRC-20004), UK.This paper was funded by grants from the National Natural Science Foundation of China (82070588), High Level Creative Talents from Department of Public Health in Zhejiang Province (S2032102600032) and Project of New Century 551 Talent Nurturing in Wenzhou. G Targher, is supported in part by grants from the School of Medicine, University of Verona, Verona, Italy. C D Byrne is supported in part by the Southampton NIHR Biomedical Research Centre (IS-BRC-20004), UK.
Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
Keywords:
Telomerase, hepatocellular carcinoma, lipid metabolism, liver fibrosis, metabolic disorders, nonalcoholic fatty liver disease, therapeutic targets
Identifiers
Local EPrints ID: 447819
URI: http://eprints.soton.ac.uk/id/eprint/447819
ISSN: 1747-4124
PURE UUID: 09f7cbcb-5163-4e10-b8db-e707e22062b7
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Date deposited: 23 Mar 2021 17:37
Last modified: 17 Mar 2024 06:25
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Contributors
Author:
Liang-Jie Tang
Author:
Rafael S. Rios
Author:
Huai Zhang
Author:
Giovanni Targher
Author:
Ming-Hua Zheng
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