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Association study of a dopamine transporter polymorphism and attention deficit hyperactivity disorder in the UK and Turkish Samples.

Association study of a dopamine transporter polymorphism and attention deficit hyperactivity disorder in the UK and Turkish Samples.
Association study of a dopamine transporter polymorphism and attention deficit hyperactivity disorder in the UK and Turkish Samples.
Molecular genetic studies in attention deficit hyperactivity disorder (ADHD) have focussed on candidate genes within the dopamine system, which is thought to be the main site of action of stimulant drugs, the primary pharmacological treatment of the disorder.1 Of particular interest are findings with the dopamine transporter gene (DAT1), since stimulant drugs interact directly with the transporter protein.2,3 To date, there have been eight published association studies of ADHD with a 480 base-pair allele of a variable number tandem repeat (VNTR) polymorphism in the 3'-untranslated region of the gene, five4-8 that support an association and three9-11 against. We have analysed the same VNTR marker in a dataset of UK Caucasian children and an independent dataset of Turkish Caucasian children with DSM-IV ADHD, using the transmission disequilibrium test (TDT).12 Results from the UK (2 = 8.97, P = 0.001, OR = 1.95), but not the Turkish sample (2 = 0.93, P = 0.34) support association and linkage between genetic variation at the DAT1 locus and ADHD. When considered alongside evidence from other published reports, there is only modest evidence for the association, consistent with a very small main effect for the 480-bp allele (2 = 3.45, P = 0.06, OR = 1.15), however we find significant evidence of heterogeneity between the combined dataset (2 = 22.64, df = 8, P = 0.004).
dopamine transporter, dat1, adhd, genetic association
1359-4184
425-428
Curran, S.
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Mill, J.
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Tahir, E.
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Kent, L.
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Richards, S.
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Gould, A.
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Hucket, L.
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Sharp, J.
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Batten, C.
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Fernando, S.
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Ozbay, F.
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Yazgan, Y
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Simanoff, E.
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Thompson, M.
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Taylor, E.
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Asherson, P.
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Curran, S.
c7b059fd-2e4d-4ddf-83cd-83a36b15d9bc
Mill, J.
d3a6160d-af3a-4e9e-ab59-8720d81640dd
Tahir, E.
ad6a9782-6d0f-46d3-8173-7e131a3e3b93
Kent, L.
ca1f2207-fa93-47fa-8d45-6c4afcd69347
Richards, S.
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Gould, A.
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Hucket, L.
bbc0dc33-fdc0-4876-8671-e2a0f447e154
Sharp, J.
a40b8829-1332-4bd2-b2bf-cf35d78c26ef
Batten, C.
887e3cf6-4c83-4c3b-a96c-75998d75eadb
Fernando, S.
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Ozbay, F.
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Yazgan, Y
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Simanoff, E.
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Thompson, M.
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Taylor, E.
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Asherson, P.
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Curran, S., Mill, J., Tahir, E., Kent, L., Richards, S., Gould, A., Hucket, L., Sharp, J., Batten, C., Fernando, S., Ozbay, F., Yazgan, Y, Simanoff, E., Thompson, M., Taylor, E. and Asherson, P. (2001) Association study of a dopamine transporter polymorphism and attention deficit hyperactivity disorder in the UK and Turkish Samples. Molecular Psychiatry, 6 (4), 425-428. (doi:10.1038/sj.mp.4000914).

Record type: Article

Abstract

Molecular genetic studies in attention deficit hyperactivity disorder (ADHD) have focussed on candidate genes within the dopamine system, which is thought to be the main site of action of stimulant drugs, the primary pharmacological treatment of the disorder.1 Of particular interest are findings with the dopamine transporter gene (DAT1), since stimulant drugs interact directly with the transporter protein.2,3 To date, there have been eight published association studies of ADHD with a 480 base-pair allele of a variable number tandem repeat (VNTR) polymorphism in the 3'-untranslated region of the gene, five4-8 that support an association and three9-11 against. We have analysed the same VNTR marker in a dataset of UK Caucasian children and an independent dataset of Turkish Caucasian children with DSM-IV ADHD, using the transmission disequilibrium test (TDT).12 Results from the UK (2 = 8.97, P = 0.001, OR = 1.95), but not the Turkish sample (2 = 0.93, P = 0.34) support association and linkage between genetic variation at the DAT1 locus and ADHD. When considered alongside evidence from other published reports, there is only modest evidence for the association, consistent with a very small main effect for the 480-bp allele (2 = 3.45, P = 0.06, OR = 1.15), however we find significant evidence of heterogeneity between the combined dataset (2 = 22.64, df = 8, P = 0.004).

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Published date: 2001
Keywords: dopamine transporter, dat1, adhd, genetic association

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Local EPrints ID: 44783
URI: https://eprints.soton.ac.uk/id/eprint/44783
ISSN: 1359-4184
PURE UUID: df8358f0-e6d2-45a6-80cc-b8aaa25d9658

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Date deposited: 15 Mar 2007
Last modified: 18 Jul 2019 12:21

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Contributors

Author: S. Curran
Author: J. Mill
Author: E. Tahir
Author: L. Kent
Author: S. Richards
Author: A. Gould
Author: L. Hucket
Author: J. Sharp
Author: C. Batten
Author: S. Fernando
Author: F. Ozbay
Author: Y Yazgan
Author: E. Simanoff
Author: M. Thompson
Author: E. Taylor
Author: P. Asherson

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