Proliferation indices of invasive breast carcinomas after in vivo 5‐bromo‐2′‐deoxyuridine labelling: A flow cytometric study of 75 tumours
Proliferation indices of invasive breast carcinomas after in vivo 5‐bromo‐2′‐deoxyuridine labelling: A flow cytometric study of 75 tumours
In vivo labelling of human breast tumours with 5‐bromo‐2′‐deoxyuridine and analysis of proliferation by multiparameter flow cytometry is a new tool by which the labelling index, S phase duration (Ts) and potential doubling time (Tpot) of the tumour can be estimated. Tumour specimens from 75 patients with invasive breast carcinoma were studied. Six tumours could not be analysed, and the Ts and Tpot values could not be calculated for a further 18. The median labelling index (n = 69) was 4.2 per cent. The median Ts (n = 51) was 8.7 h and the median Tpot (n = 51) was 8.2 days. The median intra‐assay coefficient of variation for determination of the labelling index was 0.29 in five tumours. There were no significant differences in the total labelling index, Ts or Tpot when patients were stratified according to lymph node status, tumour size, tumour grade or menopausal status.
335-339
Rew, D. A.
36dcc3ad-2379-4b61-a468-5c623d796887
Campbell, I. D.
36f9eac7-5354-4334-9d77-dc660f260ef1
Taylor, I.
7d2e7ab1-3f64-4a90-8c21-440866514bc6
Wilson, G. D.
f988f5ba-4829-4e87-909d-d106a6f4ebce
April 1992
Rew, D. A.
36dcc3ad-2379-4b61-a468-5c623d796887
Campbell, I. D.
36f9eac7-5354-4334-9d77-dc660f260ef1
Taylor, I.
7d2e7ab1-3f64-4a90-8c21-440866514bc6
Wilson, G. D.
f988f5ba-4829-4e87-909d-d106a6f4ebce
Rew, D. A., Campbell, I. D., Taylor, I. and Wilson, G. D.
(1992)
Proliferation indices of invasive breast carcinomas after in vivo 5‐bromo‐2′‐deoxyuridine labelling: A flow cytometric study of 75 tumours.
British Journal of Surgery, 79 (4), .
(doi:10.1002/bjs.1800790418).
Abstract
In vivo labelling of human breast tumours with 5‐bromo‐2′‐deoxyuridine and analysis of proliferation by multiparameter flow cytometry is a new tool by which the labelling index, S phase duration (Ts) and potential doubling time (Tpot) of the tumour can be estimated. Tumour specimens from 75 patients with invasive breast carcinoma were studied. Six tumours could not be analysed, and the Ts and Tpot values could not be calculated for a further 18. The median labelling index (n = 69) was 4.2 per cent. The median Ts (n = 51) was 8.7 h and the median Tpot (n = 51) was 8.2 days. The median intra‐assay coefficient of variation for determination of the labelling index was 0.29 in five tumours. There were no significant differences in the total labelling index, Ts or Tpot when patients were stratified according to lymph node status, tumour size, tumour grade or menopausal status.
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Published date: April 1992
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Copyright 2016 Elsevier B.V., All rights reserved.
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Local EPrints ID: 447908
URI: http://eprints.soton.ac.uk/id/eprint/447908
ISSN: 0007-1323
PURE UUID: a7217b69-b96b-455f-b781-2e2d4a02b9fb
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Date deposited: 25 Mar 2021 18:29
Last modified: 17 Mar 2024 03:56
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Author:
I. D. Campbell
Author:
I. Taylor
Author:
G. D. Wilson
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