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Microfluidic platform for serial mixing experiments with in operando nuclear magnetic resonance spectroscopy

Microfluidic platform for serial mixing experiments with in operando nuclear magnetic resonance spectroscopy
Microfluidic platform for serial mixing experiments with in operando nuclear magnetic resonance spectroscopy
We present a microfluidic platform that allows in operando nuclear magnetic resonance (NMR) observation of serial mixing experiments. Gradually adding one reagent to another is a fundamental experimental modality, widely used to quantify equilibrium constants, for titrations, and in chemical kinetics studies. NMR provides a non-invasive means to quantify concentrations and to follow structural changes at the molecular level as a function of exchanged volume. Using active pneumatic valving on the microfluidic device directly inside an NMR spectrometer equipped with a transmission-line NMR microprobe, the system allows injection of aliquots and in situ mixing in a sample volume of less than 10 μL.
1473-0197
Plata, Marek
fa0e0a2a-0f55-4a6d-af90-761e5edbb2c1
Hale, William G
d98f9d64-00f9-447e-9783-185185a0b3c6
Sharma, Manvendra
e249236d-221d-4e59-8440-011f6863f891
Werner, Jorn
1b02513a-8310-4f4f-adac-dc2a466bd115
Utz, Marcel
c84ed64c-9e89-4051-af39-d401e423891b
Plata, Marek
fa0e0a2a-0f55-4a6d-af90-761e5edbb2c1
Hale, William G
d98f9d64-00f9-447e-9783-185185a0b3c6
Sharma, Manvendra
e249236d-221d-4e59-8440-011f6863f891
Werner, Jorn
1b02513a-8310-4f4f-adac-dc2a466bd115
Utz, Marcel
c84ed64c-9e89-4051-af39-d401e423891b

Plata, Marek, Hale, William G, Sharma, Manvendra, Werner, Jorn and Utz, Marcel (2021) Microfluidic platform for serial mixing experiments with in operando nuclear magnetic resonance spectroscopy. Lab on a Chip. (doi:10.1039/D0LC01100B).

Record type: Article

Abstract

We present a microfluidic platform that allows in operando nuclear magnetic resonance (NMR) observation of serial mixing experiments. Gradually adding one reagent to another is a fundamental experimental modality, widely used to quantify equilibrium constants, for titrations, and in chemical kinetics studies. NMR provides a non-invasive means to quantify concentrations and to follow structural changes at the molecular level as a function of exchanged volume. Using active pneumatic valving on the microfluidic device directly inside an NMR spectrometer equipped with a transmission-line NMR microprobe, the system allows injection of aliquots and in situ mixing in a sample volume of less than 10 μL.

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More information

Accepted/In Press date: 2 February 2021
e-pub ahead of print date: 4 March 2021

Identifiers

Local EPrints ID: 448093
URI: http://eprints.soton.ac.uk/id/eprint/448093
ISSN: 1473-0197
PURE UUID: 8cf27f4a-11fb-4bbb-ac96-03c9c81b0526
ORCID for Jorn Werner: ORCID iD orcid.org/0000-0002-4712-1833
ORCID for Marcel Utz: ORCID iD orcid.org/0000-0003-2274-9672

Catalogue record

Date deposited: 01 Apr 2021 15:58
Last modified: 13 Apr 2021 01:46

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Contributors

Author: Marek Plata
Author: William G Hale
Author: Manvendra Sharma
Author: Jorn Werner ORCID iD
Author: Marcel Utz ORCID iD

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