Kinetic investigation of a cucurbit[7]uril-based pseudo[6]rotaxane system by microfluidic nuclear magnetic resonance
Kinetic investigation of a cucurbit[7]uril-based pseudo[6]rotaxane system by microfluidic nuclear magnetic resonance
It is challenging to investigate fast supramolecular processes due to the lack of appropriate characterization methods with high structural resolution. In this
study, microfluidic nuclear magnetic resonance (μFNMR) spectroscopy was employed to monitor the kinetics of threading and dethreading of a pseudo
[6]rotaxane system. By employing high time resolution μF-NMR, 1
H and two-dimensional (2D) rotating frame nuclear Overhauser effect spectroscopy (ROESY) NMR spectra were recorded at any time
point within 1.5 s after the onset of the process. This technique enabled the successful identification of kinetic intermediates and rate-determining steps,
usually impossible to determine by other spectroscopic techniques. Thus, our study demonstrates the capability of μF-NMR in investigating the mechanism
of complex supramolecular systems.
cucurbit[7]uril, β-Cyclodextrin, host-guest chemistry, kinetics, microfluidics NMR
948–956
Sun, Yibin
e771c98f-f275-45be-bd04-eb48bc3db2ba
Fang, Hongxun
a85933d0-7747-4b6b-aca5-e545e41f5d56
Lin, Xujing
88d0fa2e-bb69-4234-9528-87d0fbd8ee81
Wang, Xiuxiu
ef12857d-2a9c-45a3-9bdc-d90370b18f23
Chen, Ganyu
b721a924-4b77-463d-bc2a-64b7adbbf17d
Wang, Xinchang
d68c3b67-d334-485f-9d7f-fd768a11442d
Tian, Zhongqun
1d4df9bf-8b6a-4191-bc3a-91bc107ed580
Yang, Liulin
a4105373-ef07-4b51-9a56-b59f9fd78089
Utz, Marcel
c84ed64c-9e89-4051-af39-d401e423891b
Cao, Xiaoyu
7835d358-56da-482e-b061-c76c847a1525
Sun, Yibin
e771c98f-f275-45be-bd04-eb48bc3db2ba
Fang, Hongxun
a85933d0-7747-4b6b-aca5-e545e41f5d56
Lin, Xujing
88d0fa2e-bb69-4234-9528-87d0fbd8ee81
Wang, Xiuxiu
ef12857d-2a9c-45a3-9bdc-d90370b18f23
Chen, Ganyu
b721a924-4b77-463d-bc2a-64b7adbbf17d
Wang, Xinchang
d68c3b67-d334-485f-9d7f-fd768a11442d
Tian, Zhongqun
1d4df9bf-8b6a-4191-bc3a-91bc107ed580
Yang, Liulin
a4105373-ef07-4b51-9a56-b59f9fd78089
Utz, Marcel
c84ed64c-9e89-4051-af39-d401e423891b
Cao, Xiaoyu
7835d358-56da-482e-b061-c76c847a1525
Sun, Yibin, Fang, Hongxun, Lin, Xujing, Wang, Xiuxiu, Chen, Ganyu, Wang, Xinchang, Tian, Zhongqun, Yang, Liulin, Utz, Marcel and Cao, Xiaoyu
(2021)
Kinetic investigation of a cucurbit[7]uril-based pseudo[6]rotaxane system by microfluidic nuclear magnetic resonance.
Chemistry, 2021 (3), .
(doi:10.31635/ccschem.021.202100773).
Abstract
It is challenging to investigate fast supramolecular processes due to the lack of appropriate characterization methods with high structural resolution. In this
study, microfluidic nuclear magnetic resonance (μFNMR) spectroscopy was employed to monitor the kinetics of threading and dethreading of a pseudo
[6]rotaxane system. By employing high time resolution μF-NMR, 1
H and two-dimensional (2D) rotating frame nuclear Overhauser effect spectroscopy (ROESY) NMR spectra were recorded at any time
point within 1.5 s after the onset of the process. This technique enabled the successful identification of kinetic intermediates and rate-determining steps,
usually impossible to determine by other spectroscopic techniques. Thus, our study demonstrates the capability of μF-NMR in investigating the mechanism
of complex supramolecular systems.
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More information
Accepted/In Press date: 24 February 2021
e-pub ahead of print date: 12 April 2021
Keywords:
cucurbit[7]uril, β-Cyclodextrin, host-guest chemistry, kinetics, microfluidics NMR
Identifiers
Local EPrints ID: 448116
URI: http://eprints.soton.ac.uk/id/eprint/448116
ISSN: 2192-6549
PURE UUID: a2e94112-d8ff-4c23-b154-864585259bf3
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Date deposited: 01 Apr 2021 15:59
Last modified: 17 Mar 2024 03:30
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Contributors
Author:
Yibin Sun
Author:
Hongxun Fang
Author:
Xujing Lin
Author:
Xiuxiu Wang
Author:
Ganyu Chen
Author:
Xinchang Wang
Author:
Zhongqun Tian
Author:
Liulin Yang
Author:
Xiaoyu Cao
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