Cytokine profile in human corneal inflammatory disease
Cytokine profile in human corneal inflammatory disease
Purpose: cytokines play a central role in the pathogenesis of corneal inflammatory disease (CID). Despite our current knowledge, the profile of different cytokines in human CID is not clear. Our aim was to determine the cytokine levels in patients with CID.
Methods: tear samples were obtained from controls(n=5) and CID(n=8) patients. Controls were from a similar group & excluded on the basis of previous eye surgery, contact lens wear, blepharitis and use of eye drops. Simultaneous analysis of cytokine levels in collected tears were performed using multiplexed immunoassays. The mean levels of GM-CSF, IFN-γ, IL-1β, IL-2, IL-6, IL-8, IL-10, IL-12, and TNF-α were measured in both groups of patients.
Results: mean cytokine levels for control and ulcer patients are shown in Fig 1 & 2. There were significant increased levels (p<0.05) of IL-1β, IL-2, IL-6, IL-8 & GM-CSF in CID patients. There were also increases in TNF-α & IFN-γ, however, little change in IL-10.
Hossain, P.
563de5fc-84ad-4539-9228-bde0237eaf51
Afshar, F.
40e80a6d-3b24-4673-8c0c-a9d0716eb554
Webb, C.
b4687e1a-bf05-4a7e-8b83-fb5f5f92ce9e
Pender, S.L.
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Anderson, D.F.
de3b2d61-3698-4c8f-adcf-604483666fda
May 2008
Hossain, P.
563de5fc-84ad-4539-9228-bde0237eaf51
Afshar, F.
40e80a6d-3b24-4673-8c0c-a9d0716eb554
Webb, C.
b4687e1a-bf05-4a7e-8b83-fb5f5f92ce9e
Pender, S.L.
62528b03-ec42-41bb-80fe-48454c2c5242
Anderson, D.F.
de3b2d61-3698-4c8f-adcf-604483666fda
Hossain, P., Afshar, F., Webb, C., Pender, S.L. and Anderson, D.F.
(2008)
Cytokine profile in human corneal inflammatory disease.
Investigative Ophthalmology & Visual Science, 49 (13).
Record type:
Meeting abstract
Abstract
Purpose: cytokines play a central role in the pathogenesis of corneal inflammatory disease (CID). Despite our current knowledge, the profile of different cytokines in human CID is not clear. Our aim was to determine the cytokine levels in patients with CID.
Methods: tear samples were obtained from controls(n=5) and CID(n=8) patients. Controls were from a similar group & excluded on the basis of previous eye surgery, contact lens wear, blepharitis and use of eye drops. Simultaneous analysis of cytokine levels in collected tears were performed using multiplexed immunoassays. The mean levels of GM-CSF, IFN-γ, IL-1β, IL-2, IL-6, IL-8, IL-10, IL-12, and TNF-α were measured in both groups of patients.
Results: mean cytokine levels for control and ulcer patients are shown in Fig 1 & 2. There were significant increased levels (p<0.05) of IL-1β, IL-2, IL-6, IL-8 & GM-CSF in CID patients. There were also increases in TNF-α & IFN-γ, however, little change in IL-10.
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Published date: May 2008
Identifiers
Local EPrints ID: 448134
URI: http://eprints.soton.ac.uk/id/eprint/448134
ISSN: 0146-0404
PURE UUID: a4d7de80-4457-4d93-814b-62a47990a511
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Date deposited: 12 Apr 2021 16:46
Last modified: 17 Mar 2024 03:04
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Author:
F. Afshar
Author:
C. Webb
Author:
D.F. Anderson
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