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Cytokine profile in human corneal inflammatory disease

Cytokine profile in human corneal inflammatory disease
Cytokine profile in human corneal inflammatory disease
Purpose: : Cytokines play a central role in the pathogenesis of corneal inflammatory disease (CID). Despite our current knowledge, the profile of different cytokines in human CID is not clear. Our aim was to determine the cytokine levels in patients with CID. Methods: : Tear samples were obtained from controls(n=5) and CID(n=8) patients. Controls were from a similar group & excluded on the basis of previous eye surgery, contact lens wear, blepharitis and use of eye drops. Simultaneous analysis of cytokine levels in collected tears were performed using multiplexed immunoassays. The mean levels of GM-CSF, IFN-γ, IL-1β, IL-2, IL-6, IL-8, IL-10, IL-12, and TNF-α were measured in both groups of patients. Results: : Mean cytokine levels for control and ulcer patients are shown in Fig 1 & 2. There were significant increased levels (p<0.05) of IL-1β, IL-2, IL-6, IL-8 & GM-CSF in CID patients. There were also increases in TNF-α & IFN-γ, however, little change in IL-10.
0146-0404
Hossain, Parwez
563de5fc-84ad-4539-9228-bde0237eaf51
Afshar, M.F.
40e80a6d-3b24-4673-8c0c-a9d0716eb554
Webb, Claire
b4687e1a-bf05-4a7e-8b83-fb5f5f92ce9e
Pender, Sylvia
62528b03-ec42-41bb-80fe-48454c2c5242
Anderson, David F.
de3b2d61-3698-4c8f-adcf-604483666fda
Hossain, Parwez
563de5fc-84ad-4539-9228-bde0237eaf51
Afshar, M.F.
40e80a6d-3b24-4673-8c0c-a9d0716eb554
Webb, Claire
b4687e1a-bf05-4a7e-8b83-fb5f5f92ce9e
Pender, Sylvia
62528b03-ec42-41bb-80fe-48454c2c5242
Anderson, David F.
de3b2d61-3698-4c8f-adcf-604483666fda

Hossain, Parwez, Afshar, M.F., Webb, Claire, Pender, Sylvia and Anderson, David F. (2008) Cytokine profile in human corneal inflammatory disease. Investigative Ophthalmology & Visual Science, 49 (13).

Record type: Meeting abstract

Abstract

Purpose: : Cytokines play a central role in the pathogenesis of corneal inflammatory disease (CID). Despite our current knowledge, the profile of different cytokines in human CID is not clear. Our aim was to determine the cytokine levels in patients with CID. Methods: : Tear samples were obtained from controls(n=5) and CID(n=8) patients. Controls were from a similar group & excluded on the basis of previous eye surgery, contact lens wear, blepharitis and use of eye drops. Simultaneous analysis of cytokine levels in collected tears were performed using multiplexed immunoassays. The mean levels of GM-CSF, IFN-γ, IL-1β, IL-2, IL-6, IL-8, IL-10, IL-12, and TNF-α were measured in both groups of patients. Results: : Mean cytokine levels for control and ulcer patients are shown in Fig 1 & 2. There were significant increased levels (p<0.05) of IL-1β, IL-2, IL-6, IL-8 & GM-CSF in CID patients. There were also increases in TNF-α & IFN-γ, however, little change in IL-10.

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More information

Published date: May 2008

Identifiers

Local EPrints ID: 448134
URI: http://eprints.soton.ac.uk/id/eprint/448134
ISSN: 0146-0404
PURE UUID: a4d7de80-4457-4d93-814b-62a47990a511
ORCID for Parwez Hossain: ORCID iD orcid.org/0000-0002-3131-2395
ORCID for Sylvia Pender: ORCID iD orcid.org/0000-0001-6332-0333

Catalogue record

Date deposited: 12 Apr 2021 16:46
Last modified: 13 Apr 2021 01:41

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Contributors

Author: Parwez Hossain ORCID iD
Author: M.F. Afshar
Author: Claire Webb
Author: Sylvia Pender ORCID iD
Author: David F. Anderson

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