Imaging and diagnostic capabilities of anterior segment optical coherence tomography in microbial keratitis
Imaging and diagnostic capabilities of anterior segment optical coherence tomography in microbial keratitis
Purpose: Anterior segment optical coherence tomography (AS-OCT) provides high-resolution non-contact corneal scans. We have investigated the imaging and diagnostic capabilities of AS-OCT in microbial keratitis. Primary aim was to assess the ability of AS-OCT to measure corneal thickness in the area affected by microbial keratitis. Secondary aim was to assess AS-OCT qualitative and quantitative parameters during the course of the disease.
Method: A prospective study of 10 patients (eyes) with culture proven microbial keratitis. Patients underwent standard clinical examination and treatment based on slit-lamp findings. AS-OCT scanning was performed on presentation, 2–4 days, 6–8 days, and14 days or longer on treatment. In all scans the scanning beam passed through the centre of the infiltration at a specific meridian. All scans were performed by one investigator.
Results: Corneal thickness in the infiltrated region could be measured in nine eyes; in one eye the endothelial surface was indistinguishable from an endothelial inflammatory mass. Eight of these nine eyes responded well to topical antibiotic treatment, one required penetrating keratoplasty. In all 8 cases, clinical improvement was associated with reduction in corneal thickness on serial scanning. Mean corneal thickness on presentation was 939 mm (SD 89), decreasing to 797mm (SD 80) (p = 0.08), 703 mm (SD 60) (p < 0.05) and 640 mm(SD 64) (p < 0.05) at the above intervals. In the eye that required surgery, clinical deterioration correlated with AS-OCT corneal thinning progression and descmetocoele formation. Other parameters that could be measured included infiltration depth and dimensions of endothelial inflammatory mass. AS-OCT provided a range of qualitative parameters. Corneal infiltration was imaged as a hyper-reflective area in the corneal stroma. Anterior chamber inflammatory cells and retrocorneal pathology could also be imaged.
Conclusion: AS-OCT imaging provides a range of parameters that can be used to objectively assess microbial keratitis. Serial scans can aid objective evaluation of response to treatment.
A186
Anderson, David F.
de3b2d61-3698-4c8f-adcf-604483666fda
Hossain, Parwez
563de5fc-84ad-4539-9228-bde0237eaf51
18 July 2008
Anderson, David F.
de3b2d61-3698-4c8f-adcf-604483666fda
Hossain, Parwez
563de5fc-84ad-4539-9228-bde0237eaf51
Anderson, David F. and Hossain, Parwez
(2008)
Imaging and diagnostic capabilities of anterior segment optical coherence tomography in microbial keratitis.
Clinical and Experimental Dermatology, .
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Meeting abstract
Abstract
Purpose: Anterior segment optical coherence tomography (AS-OCT) provides high-resolution non-contact corneal scans. We have investigated the imaging and diagnostic capabilities of AS-OCT in microbial keratitis. Primary aim was to assess the ability of AS-OCT to measure corneal thickness in the area affected by microbial keratitis. Secondary aim was to assess AS-OCT qualitative and quantitative parameters during the course of the disease.
Method: A prospective study of 10 patients (eyes) with culture proven microbial keratitis. Patients underwent standard clinical examination and treatment based on slit-lamp findings. AS-OCT scanning was performed on presentation, 2–4 days, 6–8 days, and14 days or longer on treatment. In all scans the scanning beam passed through the centre of the infiltration at a specific meridian. All scans were performed by one investigator.
Results: Corneal thickness in the infiltrated region could be measured in nine eyes; in one eye the endothelial surface was indistinguishable from an endothelial inflammatory mass. Eight of these nine eyes responded well to topical antibiotic treatment, one required penetrating keratoplasty. In all 8 cases, clinical improvement was associated with reduction in corneal thickness on serial scanning. Mean corneal thickness on presentation was 939 mm (SD 89), decreasing to 797mm (SD 80) (p = 0.08), 703 mm (SD 60) (p < 0.05) and 640 mm(SD 64) (p < 0.05) at the above intervals. In the eye that required surgery, clinical deterioration correlated with AS-OCT corneal thinning progression and descmetocoele formation. Other parameters that could be measured included infiltration depth and dimensions of endothelial inflammatory mass. AS-OCT provided a range of qualitative parameters. Corneal infiltration was imaged as a hyper-reflective area in the corneal stroma. Anterior chamber inflammatory cells and retrocorneal pathology could also be imaged.
Conclusion: AS-OCT imaging provides a range of parameters that can be used to objectively assess microbial keratitis. Serial scans can aid objective evaluation of response to treatment.
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Published date: 18 July 2008
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Local EPrints ID: 448151
URI: http://eprints.soton.ac.uk/id/eprint/448151
ISSN: 0307-6938
PURE UUID: 22df3502-3b40-4e20-a156-7e7e929cbaf6
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Date deposited: 13 Apr 2021 16:30
Last modified: 08 Sep 2022 01:45
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Author:
David F. Anderson
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