Activating mutations in BRAF disrupt the hypothalamo-pituitary axis leading to hypopituitarism in mice and humans

Accepted/In Press date: 22 February 2021

Published date: December 2021

Additional Information: Funding Information: We apologise to the authors whose work we were unable to reference due to space constraints. We thank Simon Rhodes and J. Drouin for providing the PIT1 and TPIT antibodies. The human embryonic and foetal material was provided by the Joint MRC/ Wellcome Trust (grant# MR/R006237/1) Human Developmental Biology Resource (www. hdbr.org). The research is funded by Action Medical Research (GN 2272) and BTLC (GN 417/2238 and MGU0551). R.T. and J.B. were funded by MRC-CRTF (MR/P018459/1 and MR/S037896). V.S., M.L.V, A.G. and C.G.-M. were funded by Early Career Fellowship from the Medical College of Saint Bartholomew’s Hospital Trust. P.R.C. and P.C. were supported by grants from CRUK (C15966/A24375), BTLC (297/2249) and BBSRC (BB/ M006174/1). R.E.J.B. was funded by NIHR from an academic Clinical Lectureship award. Y.A. was supported by Japan Agency for Medical Research and Development under Grant (JP18ek0109241 and JP20ek0109470), and S.I. by JSPS KAKENHI Grant Number 18K07811. M.T.D. was funded by the Great Ormond Street Hospital (GOSH) Children’s Charity, the NIHR GOSH BRC, and partially funded by the Medical Research Foundation (MRF-099-0002-RG-UCLIC). The analysis performed by GOSgene in this study is in part supported by the National Institute for Health Research (NIHR), GOSH and the Biomedical Research Centre (BRC). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. Publisher Copyright: © 2021, The Author(s).

Local EPrints ID: 448314

URI: http://eprints.soton.ac.uk/id/eprint/448314

DOI: doi:10.1038/s41467-021-21712-4

ISSN: 2041-1723

PURE UUID: 34b9527b-9ecc-4e7b-8e2f-4638a34d9229

ORCID for Karen Temple: orcid.org/0000-0002-6045-1781

Date deposited: 20 Apr 2021 16:30

Last modified: 06 Jun 2024 01:37